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Table 3 Multivariable MR analyses for the Causal Effect of RC on FI

From: Association of remnant cholesterol with frailty: findings from observational and Mendelian randomization analyses

Adjustment

β (95% CI)

P-value

TC and LDL-C

0.086 (0.012, 0.161)

0.024*

CHD

0.032 (0.006, 0.058)

0.001**

HF

0.043 (0.018, 0.067)

5.67E-04***

Stroke

0.051 (0.025, 0.076)

9.05E-05***

T2DM

0.068 (0.027, 0.108)

0.001**

BMI

0.069 (0.031, 0.107)

2.11E-04***

SBP

0.047 (0.021, 0.073)

4.30E-04

DBP

0.041 (0.015, 0.067)

0.002**

  1. Notes: The effect size (β) is per 1 mmol/L increase in RC. LDL-C Low-density lipoprotein cholesterol, TC Total cholesterol, T2DM Type 2 diabetes mellitus, HF Heart failure, BMI Body mass index. *, < 0.05; **, < 0.01; ***, < 0.001
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Lipids in Health and Disease

ISSN: 1476-511X