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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1/β-catenin pathway in atherosclerosis

Fig. 3

The inhibition of Sirt6 leads to an increase in lipid droplet accumulation in macrophages. A Number of lipid droplets observed in macrophages untreated (none) or treated with Ac-LDL and cultured in Ad-sh-Sirt6 or Ad-Sirt6 medium; BODIPY 493/503 was used to stain the LDs in macrophages. B The average number of LDs; C Average LD size(pixels), data are presented as mean ± SEM (One way ANOVA showed that there was statistical significance among groups, *P < 0.05 vs the control group; #P < 0.05 vs the Ac-LDL group; &P < 0.05 vs the Ac-LDL + Ad-sh-Sirt6 group). C Visualisation of lipid droplets via electron microscopy (n = 6 independent experiments)

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Lipids in Health and Disease

ISSN: 1476-511X