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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1/β-catenin pathway in atherosclerosis

Fig. 5

Overexpression of Sirt6 enhances autophagy-mediated breakdown of lipid droplets in macrophages. A Co-localisation of LC3 (red) with BODIPY 493/503 (green) in Ac-LDL-treated macrophages cultured in Ad-sh-Sirt6 or Ad-Sirt6 medium. B Macrophages were incubated with Ac-LDL for 30 h and subsequently for 30 min with Bodipy 493/503 (10 µg/mL) in the presence or absence of LysoTracker Red (50 nM) before visualisation. C Co-localisation between the macrophage lipid droplet coat protein adipophilin (green) and LAMP1-positive lysosomes (red) in Ac-LDL-treated macrophages (n = 6 separate experiments)

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Lipids in Health and Disease

ISSN: 1476-511X