Table 5 The anthropometric and biochemical characteristics of the two research SNPs. Non-Gaussian variables are shown as medians with the first and third quartiles, whereas Gaussian variables are presented as the mean plus or minus SD. Statistical significance is indicated by a P value lower than 0.05. For rs737337 and rs2278426, the letters “a”, “b”, and “d” denote a substantial difference in comparison to the TT, CT, and CC genotypes, respectively

rs737337 (T/C)

N (M/F)

262 (173/89)

119 (76/43)

42 (32/10)

0.339

161 (108/53)

0.824

Age (years)

55 ± 8.12

58.23 ± 7.86

56.23 ± 7.97

0.355

57.43 ± 7.90

0.164

BMI (kg/m²)

28.05 ± 3.88

25.89 ± 4.34

26.26 ± 4.41

0.343

26.03 ± 4.33

0.154

Insulin

8.07 ± 5.11 d

5.37 ± 3.75

5.23 ± 3.94

0.039

5.31 ± 3.79

0.014

HOMA-IR

2.67 ± 2.07 d

1.58 ± 1.34 a

1.58 ± 1.78

0.009

1.58 ± 1.51

0.003

AST

22.85 ± 7.66

20.47 ± 6.32

21.91 ± 7.58

0.134

21.03 ± 6.82

0.048

ALT

25.26 ± 12.06

19.51 ± 6.97 a

23.8 ± 8.53

0.024

21.20 ± 7.84

0.009

ANGPTL8

252.39 ± 50.02

223.95 ± 45.54 a

199.22 ± 41.96 a

˂0.001

214.21 ± 45.49

0.000

SBP (mmHg)

133.27 ± 19.27

130.35 ± 19.85

124.38 ± 16

0.373

128.0 ± 18.53

0.314

DBP (mmHg)

79.6 ± 12.04 d

81.85 ± 13.43

73.35 ± 11.15

0.037

78.50 ± 13.17

0.241

Glucose

98.73 ± 13.65

94.65 ± 12.3

94.31 ± 13.04

0.147

94.51 ± 12.5

0.056

Triglyceride

151.8 ± 53.53 d

141.73 ± 45 d

106.96 ± 60.38

˂0.001

128.03 ± 53.94

0.000

Total Cholesterol

184.64 ± 44.75

174.58 ± 53.36 d

138.77 ± 49.5 a

˂0.001

160.46 ± 54.41

0.001

HDL Cholesterol

43.34 ± 7.35

42.43 ± 7.44

45.92 ± 10.94

0.115

43.80 ± 9.06

0.228

LDL Cholesterol

118.09 ± 34.76 d

107.63 ± 40.21 d

80.5 ± 35.28

˂0.001

96.93 ± 40.33

0.005

RC

32 ± 17.39

32.16 ± 17.04

25.74 ± 16.36

0.088

30.57 ± 17.04

0.27

LSM

6.56 ± 2.49

6.33 ± 2.47

6.50 ± 2.92

0.628

6.37 ± 2.59

0.345

rs2278426(C/T)

Parameters

CC

CT

TT

PValue

CT + TT

PValue

N (M/F)

12 (7/5)

80 (56/24)

331 (218/113)

0.651

92 (63/29)

0.638

Age (years)

54.33 ± 9.18

56.27 ± 8.78

55.95 ± 7.93

0.420

55.97 ± 8.75

0.783

BMI (kg/m²)

27.87 ± 5.53

28.04 ± 3.9

27.04 ± 4.18

0.964

28.02 ± 4.11

0.994

Insulin

6.42 ± 6.41

8.46 ± 6.08

6.65 ± 4.34

0.474

8.15 ± 6.09

0.363

HOMA-IR

1.7 ± 1.55

2.96 ± 2.47

2.08 ± 1.77

0.285

2.76 ± 2.38

0.173

AST

28.7 ± 13.34

22.41 ± 7.27

21.77 ± 6.98

0.597

23.38 ± 8.55

0.893

ALT

33.8 ± 19.88

23.11 ± 10.64

23.35 ± 10.14

0.891

24.75 ± 12.75

0.698

ANGPTL8

325.18 ± 64.77 d

260.58 ± 48.37 d, a

227.56 ± 46.25 d, a

˂0.001

270.52 ± 55.5

0.000

SBP (mmHg)

131.17 ± 20.79

137.03 ± 15.61

129.74 ± 19.68

0.388

136.13 ± 16.33

0.230

DBP (mmHg)

80.67 ± 11.24

82.06 ± 10.56

78.37 ± 12.92

0.775

81.85 ± 10.52

0.476

Glucose

90.5 ± 3.73

99.03 ± 12.92

96.89 ± 13.66

0.528

97.72 ± 12.34

0.656

Triglyceride

146.5 ± 38.54

154.33 ± 58.55

139.33 ± 54.34

0.171

153.12 ± 55.592

0.061

Total Cholesterol

210 ± 48.76

185.0606 ± 54.33

171.09 ± 48.32

0.363

188.89 ± 53.68

0.547

HDL Cholesterol

41.83 ± 9.33

44.8485 ± 6.58

43.26 ± 8.33

0.853

44.38 ± 7.00

0.825

LDL Cholesterol

107.6 ± 37.4

114.57 ± 41.39

132.00 ± 37.59

0.837

103.56 ± 36.91

0.073

RC

30.81 ± 17.23^b

34.98 ± 16.92

27.27 ± 17.92

0.049

35.55 ± 17.06

0.017

LSM

6.38 ± 2.49

6.95 ± 2.68

6.43 ± 2.76

0.257

6.88 ± 2.68

0.143