Table 7 The odds ratio (95% confidence interval) indicating the risk of NAFLD score associated with gene variants in the rs2278426 SNP. The univariate values are represented by ORa and pa, while the values after adjustment for age and gender are represented by ORb and pb. To determine the presence of obesity, a BMI greater than 30 kg/m2 was considered; hypertension was indicated by blood pressure equal to or greater than 130/85 mmHg; elevated levels of AST (> 35 IU/L); elevated levels of ALT (> 38 IU/L); low HDL-C was defined as HDL-cholesterol levels lower than 40 mg/dL for men and lower than 50 mg/dL for women; hypertriglyceridemia was identified if triglyceride levels were equal to or greater than 150 mg/dL; hypercholesterolemia was defined as total cholesterol greater than 200 mg/dL; and high glucose was considered present if fasting glucose levels were equal to or greater than 126 mg/dL. The presence of NAFLD was determined based on the IDF criteria. A P value less than 0.05 was considered statistically significant
Parameters | Yes | β | OR (95% CI)a | Pa | OR (95% CI)b | Pb | |
|---|---|---|---|---|---|---|---|
Obes (kg/m2) | CC | 73 | 1 | ||||
CT | 16 | -0.124 | 0.884 (0.48–1.62) | 0.68 | 0.893 (0.48–1.64) | 0.716 | |
TT | 3 | 0.164 | 1.178 (0.31–4.46) | 0.809 | 1.13 (0.29–4.30) | 0.857 | |
CT + TT | 19 | -0.084 | 0.92 (0.521–1.623) | 0.773 | 0.924 (0.523–1.632) | 0.785 | |
C | |||||||
T | 19 | -0.084 | 0.92 (0.521–1.623) | 0.773 | 0.924 (0.523–1.632) | 0.785 | |
High AST | CC | 11 | 1 | ||||
CT | 2 | − 0.0293 | 0.746 (0.162–3.434) | 0.707 | 0.814 (0.17–3.907) | 0.797 | |
TT | 2 | 1.761 | 5.81 (1.137–29.779) | 0.035 | 6.329 (1.003–39.950) | 0.050 | |
CT + TT | 4 | 0.279 | 1.322 (0.411–4.254) | 0.639 | 1.451 (0.431–4.886) | 0.548 | |
C | |||||||
T | 4 | 0.279 | 1.322 (0.411–4.254) | 0.639 | 1.451 (0.431–4.886) | 0.548 | |
High ALT | CC | 30 | 1 | ||||
CT | 6 | -0.206 | 0.814 (0.327–2.026) | 0.658 | 0.924 (0.363–2.356) | 0.869 | |
TT | 3 | 1.207 | 3.34 (0.859–13.024) | 0.082 | 2.857 (0.692–11.801) | 0.147 | |
CT + TT | 9 | 0.084 | 1.088 (0.497–2.382) | 0.833 | 1.189 (0.531–2.666) | 0.674 | |
C | |||||||
T | 9 | 0.084 | 1.088 (0.497–2.382) | 0.833 | 1.189 (0.531–2.666) | 0.674 | |
SBP (mmHg) | CC | 146 | 1 | ||||
CT | 38 | 0.137 | 1.146 (0.703–1.870) | 0.584 | 1.164 (0.711–1.906) | 0.545 | |
TT | 4 | -0.456 | 0.634 (0.187–2.145) | 0.463 | 0.620 (0.182–2.119) | 0.446 | |
CT + TT | 42 | 0.062 | 1.064 (0.669–1.693) | 0.792 | 1.075 (0.674–1.715) | 0.760 | |
C | |||||||
T | 42 | 0.062 | 1.064 (0.669–1.693) | 0.792 | 1.075 (0.674–1.715) | 0.76 | |
DBP (mmHg) | CC | 101 | 1 | ||||
CT | 32 | 0.417 | 1.518 (0.916–2.515) | 0.105 | 1.553 (0.935–2.579) | 0.089 | |
TT | 5 | 0.486 | 1.627 (0.504–5.247) | 0.416 | 1.557 (0.480–5.054) | 0.461 | |
CT + TT | 37 | 0.427 | 1.532 (0.950–2.471 | 0.080 | 1.553 (0.961–2.510) | 0.072 | |
C | |||||||
T | 37 | 0.427 | 1.532 (0.95–2.471) | 0.080 | 1.553 (0.961–2.510) | 0.072 | |
High Glucose | CC | 1 | 1 | ||||
CT | 0 | -15.404 | 0.000 | 0.997 | 0.000 | 0.997 | |
TT | 0 | -15.404 | 0.000 | 0.999 | 0.000 | 0.999 | |
CT + TT | 0 | -15.404 | 0.000 | 0.997 | 0.000 | 0.997 | |
C | |||||||
T | 0 | -15.404 | 0.000 | 0.997 | 0.000 | 0.997 | |
Hyper Triglyceridemia | CC | 138 | 1 | ||||
CT | 37 | 0.185 | 1.203 (0.737–1.966) | 0.460 | 1.217 (0.743–1.993) | 0.436 | |
TT | 7 | 0.672 | 1.958 (0.609–6.298) | 0.260 | 1.883 (0.582–6.090) | 0.291 | |
CT + TT | 44 | 0.248 | 1.282 (0.806–2.038) | 0.294 | 1.288 (0.808–2.052) | 0.287 | |
C | |||||||
T | 44 | 0.248 | 1.282 (0.806–2.038) | 0.294 | 1.288 (0.808–2.052) | 0.287 | |
Low HDL-C | CC | 170 | 1 | ||||
CT | 37 | -0.205 | 0.815 (0.499–1.330) | 0.412 | 0.834 (0.470–1.479) | 0.534 | |
TT | 7 | 0.282 | 1.326 (0.412–4.262) | 0.636 | 1.304 (0.328–5.186) | 1.304 | |
CT + TT | 44 | -0.141 | 0.868 (0.547–1.378) | 0.549 | 0.882 (0.513–1.517) | 0.649 | |
C | |||||||
T | 44 | -0.141 | 0.868 (0.547–1.378) | 0.549 | 0.882 (0.513–1.517) | 0.649 | |
High LDL | CC | 100 | 1 | ||||
CT | 25 | 0.049 | 1.050 (0.619–1.780) | 0.856 | 1.050 (0.619–1.781) | 0.856 | |
TT | 3 | -0.261 | 0.770 (0.204–2.904) | 0.700 | 0.767 (0.203–2.898) | 0.696 | |
CT + TT | 28 | 0.011 | 1.011 (0.612–1.670) | 0.967 | 1.010 (0.611–1.669) | 0.969 | |
C | |||||||
T | 28 | 0.011 | 1.011 (0.612–1.670) | 0.967 | 1.01 (0.971–1.024) | 0.827 | |
HOMA-IR | CC | 109 | |||||
CT | 31 | 0.253 | 1.289 (0.77–2.13) | 0.325 | 1.308 (0.87–2.17) | 0.298 | |
TT | 3 | -0.387 | 0.679 (0.18–2.55) | 0.567 | 0.655 (0.17–2.47) | 0.533 | |
CT + TT | 34 | 0.17 | 1.194 (0.73–1.93) | 0.471 | 1.204 (0.74–1.95) | 0.451 | |
C | |||||||
T | 34 | 0.17 | 1.194 (0.73–1.93) | 0.471 | 1.204 (0.74–1.95) | 0.451 | |
RC | CC | 251 | |||||
CT | 58 | -0.17 | 0.84(0.48–1.45) | 0.53 | 0.86(0.49–1.49) | 0.86 | |
TT | 11 | 1.125 | 3.51(0.44–27.57) | 0.23 | 3.30(0.41–26.11) | 0.25 | |
CT + TT | 69 | -0.04 | 0.95(0.56–1.63) | 0.87 | 0.96(0.56–1.66) | 0.909 | |
C | |||||||
T | 69 | -0.04 | 0.95(0.56–1.63) | 0.87 | 0.96(0.56–1.66) | 0.909 | |
NAFLD | CC | 164 | 1 | ||||
CT | 52 | 0.637 | 1.891 (1.139–3.141) | 0.014 | 1.988 (1.189–3.325) | 0.009 | |
TT | 6 | 0.018 | 1.018 (0.322–3.222) | 0.975 | 0.932 (0.290–3.003) | 0.907 | |
CT + TT | 58 | 0.522 | 1.737 (1.080–2.793 | 0.023 | 1.793 (1.108-2.900) | 0.17 | |
C | |||||||
T | 58 | 0.522 | 1.737 (1.080–2.793 | 0.023 | 1.793 (1.108-2.900) | 0.17 |