Fig. 1

Anlotinib treatment induces hyperlipidemia in C57BL/6 J mice. According to the Materials & Methods, C57BL/6 J mice were randomly assigned to one of three groups and given three different treatments for 21 consecutive days: vehicle (circles), anlotinib (squares), and rapamycin (triangles). Variations in body weights (A) and relative liver weights (liver/body weight ratio) (B) over the course of treatment. C Staining of liver sections with H&E. Scale bar = 100 μm. D The amounts of TC, TG, LDL, and HDL in the serum. *P < 0.05; **P < 0.01 by Student’s t test