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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Anlotinib affects systemic lipid metabolism and induces lipid accumulation in human lung cancer cells

Fig. 5

LDLR knockdown attenuates cancer cells sensitivity to anlotinib. A Quantitative PCR measurement of LDLR mRNA expression levels in H460 cells transfected with scramble or two separate pLKO.1-puro shRNA targeting LDLR sequences (#1 and #2). B LDLR protein expression levels were examined in scramble, #1 and #2 cells. C Intracellular TC level in scramble and #1 cells treated with different concentrations of anlotinib. D Different doses of anlotinib were administered to scramble and #1 cells during the course of 72 h. Viability was evaluated using metabolic MTT assay. *P < 0.05; **P < 0.01 by Student’s t test

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Lipids in Health and Disease

ISSN: 1476-511X