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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Periostin drives extracellular matrix degradation, stemness, and chemoresistance by activating the MAPK/ERK signaling pathway in triple–negative breast cancer cells

Fig. 3

Inhibition of periostin restores the cellular processes in TNBCs. a–b. The results of the qPCR (a) and Western blotting (b) analysis of the specificity of shRNA against POSTN in MDA–MB–231 and SUM159PT cells, where β–actin was used as the control. c–d. The results of the qPCR analysis of the MMPs (MMP2, MMP9, and MMP13) (c) and stemness–related molecules (MYC, SOX2, and NANOG) (d) in MDA–MB–231 and SUM159PT cells transfected with shPOSTN or shCtrl for 48 h. e–f. The results of the qPCR analysis of the MMPs (e) and stemness–related molecules (f) in MDA–MB–231 and SUM159PT cells treated with rhPeriostin or IgG for 24 h. *P < 0.05

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Lipids in Health and Disease

ISSN: 1476-511X