Table 4 Change in body weight following liraglutide does not mediate change in ceramide levels
| Â | LirAlbu12 | LiraFlame26 | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Total effect estimate | Total effect P-value | ACME estimate | ACME P-value | Total effect estimate | Total effect P-value | ACME estimate | ACME P-value |
C16 Cer | 0.025 (-0.03;0.079) | 0.372 | -0.004 (-0.032;0.021) | 0.718 | 2.634*10–4 (1.954*10–5;5.004*10–4) | 0.044 | 7.641*10–6 (-1.421*10–4;1.796*10–4) | 0.908 |
C18 Cer | 0.024 (-0.038;0.088) | 0.492 | 0.003 (-0.028;0.034) | 0.758 | 5.527*10–4 (-1.182*10–4;1.259*10–3) | 0.102 | 4.530*10–5 (-3.698*10–4;4.983*10–4) | 0.798 |
C20 Cer | 0.037 (-0.053;0.141) | 0.45 | 0.002 (-0.048;0.047) | 0.912 | -2.777*10–5 (-7.603*10–5;2.105*10–5) | 0.314 | 2.285*10–5 (-1.929*10–6;5.199*10–5) | 0.076 |
C22 Cer | 0.281 (-0.21;0.775) | 0.262 | 0.031 (-0.187;0.241) | 0.724 | 1.432*10–4 (-1.988*10–4;4.755*10–4) | 0.37 | 2.973*10–5 (-1.230*10–4;2.119*10–4) | 0.788 |
C24 Cer | 1.272 (-0.762;3.59) | 0.238 | -0.238 (-1.312;0.687) | 0.716 | 2.703*10–2 (-9.487*10–3;6.170*10–2) | 0.168 | -1.562*10–3 (-2.448*10–2;1.971*10–2) | 0.88 |
C24:1 Cer | -0.025 (-0.687;0.642) | 0.958 | 0.074 (-0.205;0.403) | 0.616 | 1.178*10–2 (-2.336*10–3;2.387*10–2) | 0.094 | -9.104*10–4 (-8.647*10–3;6.183*10–3) | 0.85 |