Table 4 Review of previous articles on the effects of statins in chronic subdural hematoma patients
| Â | Year | Nationality | Study design | Total No. | Subgroup distribution | Treatment measures | Medication dose | Outcomes in the statin group |
|---|---|---|---|---|---|---|---|---|
Xu M. et al. | 2016 | China | Retrospective | 109 | 7 conservative 102 post-surgical : 39 (atorvastatin) vs. 63 (control) | Conservative (with atorvastatin) or post-surgical (with or without atorvastatin) | Atorvastatin 20Â mg | Successful treatment of the conservative group More favorable post-surgical outcomes |
Chan D. et al. | 2017 | China | Retrospective | 24 | 12 atorvastatin 12 control | Post-surgical patients treated with atorvastatin | Atorvastatin 20Â mg | Less risk of deterioration requiring surgery |
Tang R. et al. | 2018 | China | Retrospective | 245 | 125 atorvastatin 120 control | Post-surgical patients with or without atorvastatin | Atorvastatin 20Â mg | Less recurrence |
Jiang R. et al. | 2018 | China | RCT | 200 | 98 patients in each group (atorvastatin or placebo) | Conservative measures with atorvastatin | Atorvastatin 20Â mg | More reduction in hematoma volume and superior neurologic function improvement Fewer patients requiring surgery |
Guidry BS. et al. | 2021 | USA | Retrospective | 111 | 36 statin 75 no statin | Post-surgical patients with or without statins | NA | Greater reduction in hematoma size |
Klein J. et al. | 2021 | Germany | Retrospective | 407 | 123 statin 284 no statin | Post-surgical patients with or without statins | NA | No evidence of a protective effect |
Present study | Â | Korea | Retrospective | 462 | 112 statin 350 no statin | Post-surgical patients with or without statins | NA | No significant effect on recurrence or reoperation |