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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis

Fig. 1

Flowchart of the study design and MR assumptions. a Outline of the study design; b Assumptions of the Mendelian randomization study: in this study, genetic instruments were selected to represent the pharmacological modulation of drug target proteins based on their associations with circulating lipid concentrations (relevance assumption). Additionally, it was assumed that the selected genetic variants are not associated with confounding factors (independence assumption). The third assumption was that genetic variants should not affect human lifespan through other pathways (exclusion restriction assumption)

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Lipids in Health and Disease

ISSN: 1476-511X