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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis

Fig. 2

Forest plot visualizing the causal effects of circulating lipids with human lifespan. The Forest plot presented the MR estimates of circulating lipids on human lifespans in the discovery (the left plot) and validation (the right plot) datasets. Beta and 95% CI were used to estimate the effects of a 1 mmol/L change of circulating lipids (LDL cholesterol 38.67 mg/dl, Triglycerides 88.57 mg/dl) on lifespan in the discovery data (quantitative traits), whereas OR and 95% CI indicated the effect estimates of a 1 mmol/L change of circulating lipids on human longevity in the validation data (binary outcomes). Abbreviations: MVMR, Multivariable Mendelian randomization; OR: Odds Ratio; FDR, False discovery rate

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Lipids in Health and Disease

ISSN: 1476-511X