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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis

Fig. 3

Causal effects of the genetically proxied lipid-lowering drug targets on human lifespan. a-b the IVW Results of positive control analysis were visualized in A (Major CHD events and Coronary atherosclerosis using GWAS databases from the FinnGen consortium) and B (T2D using GWAS databases from the FinnGen and DIAGRAM consortium). c The forest plot showed the estimated effects of 1 mmol/L lower LDL-C or TG concentration by target-specific variants in each drug target gene on human lifespan in the discovery (left) and validation sets (right), using the IVW method. Beta and 95% CI were used in quantitative outcomes, whereas OR and 95% CI were used in binary outcomes

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Lipids in Health and Disease

ISSN: 1476-511X