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Table 1 Descriptive statistics for characteristics of 11,657 mothers and their offspring by quartiles of FHR.

From: Maternal fibrinogen/fibrin degradation products to high density lipoprotein cholesterol ratio for predicting delivery of small and large for gestational age infants: a pilot study

 

FHR (mg/mmol)

P value

Q1 (< 2.70, N = 2911)

Q2 (2.70–3.98, N = 2917)

Q3 (3.99–5.90, N = 2914)

Q4 (> 5.90, N = 2915)

Maternal characteristics

 

Age (years)

28 (25–31)

28 (26–31)

28 (26–31)

28 (26–32)

< 0.001

 <20

32 (1.1%)

29 (1.0%)

31 (1.1%)

18 (0.6%)

0.090

 20–34

2613 (89.8%)

2656 (91.0%)

2668 (91.5%)

2653 (91.0%)

 ≥35

266 (9.14%)

232 (8.0%)

215 (7.4%)

244 (8.4%)

BMI (kg/m2) a

27 (25–29.3)

26.9 (25–29.3)

26.9 (24.8–29.3)

27.1 (25.1–29.4)

0.137

 <25

695 (24.2%)

736 (25.4%)

760 (26.3%)

688 (23.9%)

0.415

 25–29

1585 (55.2%)

1576 (54.4%)

1564 (54.1%)

1606 (55.7%)

 ≥30

592 (20.6%)

584 (20.2%)

565 (19.6%)

587 (20.4%)

Parity

 

 No child

1681 (57.8%)

1760 (60.3%)

1814 (62.3%)

1742 (59.8%)

0.006

 ≥ 1 child

1230 (42.3%)

1157 (39.7%)

1100 (37.7%)

1173 (40.2%)

Systolic BP (mmHg)

121 (110–130)

120 (110–130)

120 (110–130)

120 (110–128)

< 0.001

Diastolic BP (mmHg)

73 (70–80)

72 (70–80)

72 (70–80)

72 (70–79)

< 0.001

Gestational age (week)

38.4 ± 1.9

38.7 ± 1.6

38.8 ± 1.6

38.8 ± 1.5

< 0.001

Assisted reproduction

51 (1.8%)

51 (1.7%)

68 (2.3%)

100 (3.4%)

< 0.001

Delivery mode

 

 Vaginal delivery

1721 (59.1%)

1716 (58.8%)

1722 (59.1%)

1539 (52.8%)

< 0.001

 Cesarean section

1190 (40.9%)

1201 (41.2%)

1192 (40.9%)

1376 (47.2%)

Pregnancy complications b

 

 GDM

186 (6.4%)

235 (8.1%)

260 (8.9%)

296 (10.2%)

< 0.001

 ICP

149 (5.1%)

159 (5.5%)

197 (6.8%)

213 (7.3%)

< 0.001

 PE

121 (4.2%)

96 (3.3%)

97 (3.3%)

92 (3.2%)

0.146

 PIH

75 (2.6%)

71 (2.4%)

56 (1.9%)

44 (1.5%)

0.017

 PTB

306 (10.5%)

184 (6.3%)

172 (5.9%)

142 (4.9%)

< 0.001

Newborn characteristics

 

Sex

 Female

1212 (41.6%)

1283 (44.0%)

1449 (49.7%)

1554 (53.3%)

< 0.001

 Male

1699 (58.4%)

1634 (56.0%)

1465 (50.3%)

1361 (46.7%)

Birth length (cm)

49.6 ± 1.8

49.8 ± 1.3

49.9 ± 1.2

50.0 ± 1.3

< 0.001

Birth weight (g)

3250 (2950–3510)

3340 (3050–3630)

3400 (3110–3680)

3460 (3170–3750)

< 0.001

Weight for gestational age

 

 SGA

379 (13.0%)

286 (9.8%)

192 (6.6%)

177 (6.1%)

< 0.001

 AGA

2258 (77.6%)

2219 (76.1%)

2242 (76.9%)

2098 (72.0%)

 LGA

274 (9.4%)

412 (14.1%)

480 (16.5%)

640 (22.0%)

Laboratory tests

 

 hs-CRP (mg/L)

3.2 (1.8–5.5)

3.0 (1.6–5.1)

2.8 (1.5–5.0)

2.7 (1.5–4.8)

< 0.001

 Total cholesterol (mmol/L)

6.4 (5.7–7.2)

6.3 (5.6–7.1)

6.3 (5.5–7.1)

6.2 (5.4–7.1)

< 0.001

 Triglyceride (mmol/L)

3.4 (2.6–4.3)

3.5 (2.7–4.5)

3.7 (2.8–4.8)

3.8 (3.0–4.9)

< 0.001

 LDL-C (mmol/L)

3.3 (2.8–3.9)

3.3 (2.8–4.0)

3.3 (2.7–3.9)

3.3 (2.7–4.0)

0.331

 HDL-C (mmol/L)

1.9 (1.7–2.1)

1.7 (1.5–1.9)

1.6 (1.4–1.9)

1.6 (1.4–1.8)

< 0.001

 FDP (mg/L)

3.8 (3.2–4.5)

5.7 (5.0–4.5)

7.9 (6.8–9.1)

12.9 (10.6–16.3)

< 0.001

  1. Notes: Data were presented as mean ± SD, median (IQR) and N (%). a BMI was not calculated in 119 women due to missing height or weight. b 227 women were diagnosed with two complications.
  2. Abbreviations: FHR, FDP/HDL-C ratio; Q, quartile; BMI, body mass index; BP, blood pressure; PTB, preterm birth; GDM, gestational diabetes mellitus; ICP, intrahepatic cholestasis of pregnancy; PE, pre-eclampsia; PIH, pregnancy induced hypertension; SGA/AGA/LGA, small/appropriate/large for gestational age; hsCRP, high sensitive C-reactive protein; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; FDP, fibrin/fibrinogen degradation products; SD, standard deviation; IQR, interquartile range.
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Lipids in Health and Disease

ISSN: 1476-511X