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Table 3 The association of FDP, HDL-C and their ratio with fetal birth length, birth weight, and risks of SGA and LGA.

From: Maternal fibrinogen/fibrin degradation products to high density lipoprotein cholesterol ratio for predicting delivery of small and large for gestational age infants: a pilot study

 

Birth length

Birth weight

SGA

LGA

β (95% CI)

P value

β (95% CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

Unadjusted model

 

FDP (mg/L)

        

 Q1 (< 4.67)

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Q2 (4.68–6.64)

0.27 (0.19, 0.34)

< 0.001

117.40 (92.42, 142.38)

< 0.001

0.75 (0.64, 0.88)

< 0.001

1.22 (1.04, 1.42)

0.014

 Q3 (6.65–9.60)

0.41 (0.34, 0.48)

< 0.001

192.04 (166.77, 217.30)

< 0.001

0.53 (0.44, 0.64)

< 0.001

1.40 (1.20, 1.63)

< 0.001

 Q4 (> 9.60)

0.45 (0.38, 0.52)

< 0.001

241.39 (216.32, 266.47)

< 0.001

0.51 (0.43, 0.61)

< 0.001

1.91 (1.65, 2.21)

< 0.001

P for trend

 

< 0.001

 

< 0.001

 

< 0.001

 

< 0.001

HDL-C (mmol/L)

        

 Q1 (< 1.49)

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Q2 (1.49–1.70)

0.09 (0.01, 0.16)

0.021

-11.68 (-37.07, 13.72)

0.367

0.94 (0.77, 1.14)

0.523

0.78 (0.68, 0.89)

< 0.001

 Q3 (1.71–1.94)

0.01 (-0.07, 0.08)

0.841

-60.82 (-86.27, -35.36)

< 0.001

1.08 (0.89, 1.30)

0.449

0.62 (0.54, 0.72)

< 0.001

 Q4 (> 1.94)

-0.01 (-0.08, 0.07)

0.844

-114.14 (-139.46, -88.83)

< 0.001

1.36 (1.14, 1.63)

< 0.001

0.50 (0.43, 0.57)

< 0.001

P for trend

 

0.400

 

< 0.001

 

< 0.001

 

< 0.001

FHR (mg/mmol)

        

 Q1 (< 2.70)

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Q2 (2.70–3.98)

0.27 (0.20, 0.35)

< 0.001

129.67 (104.67, 154.67)

< 0.001

0.77 (0.65, 0.91)

0.002

1.53 (1.30, 1.80)

< 0.001

 Q3 (3.99–5.90)

0.33 (0.25, 0.40)

< 0.001

185.11 (160.10, 210.12)

< 0.001

0.51 (0.42, 0.61)

< 0.001

1.76 (1.50, 2.07)

< 0.001

 Q4 (> 5.90)

0.41 (0.34, 0.49)

< 0.001

263.61 (238.60, 288.61)

< 0.001

0.50 (0.42, 0.61)

< 0.001

2.51 (2.16, 2.93)

< 0.001

P for trend

 

< 0.001

 

< 0.001

 

< 0.001

 

< 0.001

Adjusted model a

        

FDP (mg/L) b

        

 Q1 (< 4.67)

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Q2 (4.68–6.64)

0.06 (0.01, 0.11)

0.012

70.35 (51.56, 89.14)

< 0.001

0.72 (0.60, 0.86)

< 0.001

1.42 (1.20, 1.69)

< 0.001

 Q3 (6.65–9.60)

0.10 (0.05, 0.14)

< 0.001

118.37 (99.19, 137.54)

< 0.001

0.49 (0.41, 0.60)

< 0.001

1.73 (1.46, 2.05)

< 0.001

 Q4 (> 9.60)

0.15 (0.10, 0.20)

< 0.001

167.58 (148.34, 186.82)

< 0.001

0.46 (0.37, 0.56)

< 0.001

2.50 (2.12, 2.95)

< 0.001

P for trend

 

< 0.001

 

< 0.001

 

< 0.001

 

< 0.001

HDL-C (mmol/L) c

        

 Q1 (< 1.49)

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Q2 (1.49–1.70)

0.03 (-0.02, 0.08)

0.247

0.18 (-19.66, 20.03)

0.986

0.85 (0.69, 1.06)

0.153

0.87 (0.74, 1.01)

0.066

 Q3 (1.71–1.94)

-0.02 (-0.08, 0.03)

0.419

-33.32 (-55.11, -11.53)

0.003

0.98 (0.78, 1.24)

0.896

0.74 (0.62, 0.88)

< 0.001

 Q4 (> 1.94)

-0.05 (-0.12, 0.01)

0.110

-69.47 (-95.40, -43.54)

< 0.001

1.15 (0.88, 1.51)

0.290

0.60 (0.48, 0.74)

< 0.001

P for trend

 

0.042

 

< 0.001

 

0.122

 

< 0.001

FHR (mg/mmol)

        

 Q1 (< 2.70)

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Q2 (2.70–3.98)

0.09 (0.04, 0.13)

< 0.001

72.04 (53.19, 90.90)

< 0.001

0.76 (0.64, 0.91)

0.003

1.63 (1.37, 1.94)

< 0.001

 Q3 (3.99–5.90)

0.12 (0.08, 0.17)

< 0.001

125.67 (106.55, 144.78)

< 0.001

0.48 (0.39, 0.58)

< 0.001

2.04 (1.71, 2.43)

< 0.001

 Q4 (> 5.90)

0.16 (0.12, 0.21)

< 0.001

180.87 (161.41, 200.32)

< 0.001

0.47 (0.38, 0.57)

< 0.001

2.85 (2.41, 3.38)

< 0.001

P for trend

 

< 0.001

 

< 0.001

 

< 0.001

 

< 0.001

  1. Notes: a adjusted for age, BMI, systolic and diastolic BP, parity, gestational age, pregnancy complications, assisted reproduction, fetal sex and the levels of total cholesterol, triglyceride, LDL-C and hs-CRP. b additionally adjusted for HDL-C level. c additionally adjusted for FDP levels.
  2. Abbreviations: FDP, fibrin/fibrinogen degradation products; HDL-C, high density lipoprotein cholesterol; SGA/LGA, small/large for gestational age; CI, confidence interval; OR, odds ratio; Q, quartile; FHR, FDP/HDL-C ratio; BMI, body mass index; BP, blood pressure; GDM, gestational diabetes mellitus; ICP, intrahepatic cholestasis of pregnancy; PE, pre-eclampsia; PIH, pregnancy induced hypertension; hsCRP, high sensitive C-reactive protein; LDL-C, low density lipoprotein cholesterol.