Maternal fibrinogen/fibrin degradation products to high density lipoprotein cholesterol ratio for predicting delivery of small and large for gestational age infants: a pilot study

Table 4 Subgroup analysis of effect modification of perinatal parameters on association between FHR and SGA offspring

	Low FHR (Q1-Q3)		High FHR (Q4)		Crude		Adjusted ^a
	Total	SGA (%)	Total	SGA (%)	OR (95%CI)	P value	OR (95%CI)	P value
Age (years)
< 35	7747	775 (10.0%)	2565	164 (6.4%)	0.67 (0.57, 0.80)	< 0.001	0.66 (0.54, 0.79)	< 0.001
≥ 35	996	82 (8.2%)	349	13 (3.7%)	0.48 (0.27, 0.84)	0.010	0.59 (0.32, 1.10)	0.096
BMI (kg/m²) ^b
< 25	2191	372 (17.0%)	688	77 (11.2%)	0.65 (0.50, 0.84)	0.001	0.63 (0.48, 0.83)	0.001
25–29	4726	384 (8.1%)	1605	78 (4.9%)	0.30 (0.24, 0.39)	< 0.001	0.30 (0.23, 0.39)	< 0.001
≥ 30	1741	91 (5.2%)	587	16 (2.7%)	0.21 (0.12, 0.35)	< 0.001	0.16 (0.10, 0.28)	< 0.001
Parity
No child	5255	589 (11.2%)	1742	119 (6.8%)	0.63 (0.52, 0.78)	< 0.001	0.63 (0.50, 0.78)	< 0.001
≥ 1 child	3488	268 (7.7%)	1172	58 (4.9%)	0.52 (0.39, 0.69)	< 0.001	0.58 (0.42, 0.79)	< 0.001
Assisted reproduction
No	8573	843 (9.8%)	2814	177 (6.3%)	0.68 (0.58, 0.81)	< 0.001	0.67 (0.55, 0.80)	< 0.001
Yes	170	14 (8.2%)	100	0 (0.0%)	—	—	—	—
Pregnancy complications ^c
No	7199	681 (9.5%)	2338	133 (5.7%)	0.63 (0.52, 0.77)	< 0.001	0.62 (0.51, 0.76)	< 0.001
GDM	681	44 (6.5%)	296	9 (3.0%)	0.42 (0.22, 0.83)	0.012	0.36 (0.16, 0.78)	0.010
ICP	505	60 (11.9%)	213	17 (8.0%)	0.95 (0.57, 1.58)	0.845	0.76 (0.43, 1.34)	0.346
PE	314	78 (24.8%)	92	23 (25.0%)	3.66 (2.23, 6.02)	< 0.001	3.76 (2.02, 6.98)	< 0.001
PIH	202	21 (10.4%)	44	1 (2.3%)	0.29 (0.04, 2.09)	0.218	0.38 (0.05, 3.03)	0.360

Notes: ^a Adjusted for age, BMI, BP, parity, assisted reproduction, hs-CRP, LDL-C, total cholesterol, triglyceride, except for the covariate that was categorized. ^b BMI was not calculated in 119 participants due to missing height or weight. ^c 227 participants were diagnosed with two complications.
Abbreviations: FHR, FDP/HDL-C ratio; SGA, small for gestational age; Q, quartile; OR, odds ratio; CI, confidence interval; BMI, body mass index; GDM, gestational diabetes mellitus; ICP, intrahepatic cholestasis of pregnancy; PE, pre-eclampsia; PIH, pregnancy induced hypertension; FDP, fibrin/fibrinogen degradation products; HDL-C, high density lipoprotein cholesterol; BP, blood pressure; hsCRP, high sensitive C-reactive protein; LDL-C, low density lipoprotein cholesterol.

ISSN: 1476-511X