Maternal fibrinogen/fibrin degradation products to high density lipoprotein cholesterol ratio for predicting delivery of small and large for gestational age infants: a pilot study

Table 6 Accuracy of FDP, HDL–C, FHR and the models to predict SGA and LGA.

	AUC	95% CI	P value	Best threshold	Specificity (%)	Sensitivity (%)	PPV (%)	NPV (%)
SGA
FDP (mg/L)^a	0.577	0.558–0.595	< 0.001	6.65	49.81	62.65	12.77	91.92
HDL–C (mmol/L)^a	0.544	0.525–0.563	< 0.001	1.89	68.67	38.79	12.72	90.50
FHR (mg/mmol)	0.587	0.569–0.606		3.72	53.96	59.96	13.25	92.00
Model 1^b	0.717	0.700–0.734	0.001	-2.18	65.25	67.73	18.46	94.57
Model 2	0.727	0.711–0.744		-2.17	66.19	67.73	18.88	94.64
LGA
FDP (mg/L)^a	0.573	0.559–0.588	< 0.001	7.75	61.84	49.55	21.18	85.56
HDL–C (mmol/L)^a	0.576	0.562–0.591	< 0.001	1.73	48.94	62.50	20.05	86.43
FHR (mg/mmol)	0.595	0.581–0.609		4.30	56.69	56.92	21.21	86.53
Model 1^b	0.725	0.712–0.737	< 0.001	-1.61	66.29	67.21	29.04	90.78
Model 2	0.739	0.726–0.751		-1.71	63.61	71.57	28.76	91.59

Notes: Model 1 included age, BMI, systolic and diastolic BP, parity, gestational age, pregnancy complications, assisted reproduction, fetal sex and the levels of total cholesterol, triglyceride, LDL-C and hsCRP. Model 2, model 1 plus FHR.
Abbreviations: AUC, area under the curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; BMI, body mass index; FDP, fibrin/fibrinogen degradation products; HDL-C, high density lipoprotein cholesterol; FHR, FDP/HDL-C ratio; P values expressed the significance of differences between FHR and FDP/HDL-C or the difference between Model 1 and Model 2.

ISSN: 1476-511X