Associations of fatty acids with the risk of biliary tract calculus and inflammation: a Mendelian randomization study

Table 1 Causal effect of polyunsaturated fatty acids on biliary tract calculus and inflammation

Exposure	Outcome	MR method	Number of SNP	OR (95% CI)	P value	Test of heterogeneity		Test of pleiotropy
Exposure	Outcome	MR method	Number of SNP	OR (95% CI)	P value	Cochrane Q test	P of heterogeneity	MR-Egger intercept	P of pleiotropy
Polyunsaturated fatty acids	Calculus of bile duct without cholangitis or cholecystitis	Inverse variance weighted	9	1.002(0.998–1.007)	0.161	16.013	0.042
		MR Egger		1.016(0.998–1.034)	0.114	12.079	0.097	-0.0004	0.174
		weighted median		1.002(0.997–1.006)	0.327
	Calculus of gallbladder without cholecystitis	Inverse variance weighted	15	1.003(0.997–1.009)	0.239	35.553	0.001
		MR Egger		1.000(0.980–1.020)	0.997	35.168	0.0007	0.0001	0.712
		weighted median		1.000(0.994–1.007)	0.789
	Cholecystitis	Inverse variance weighted	26	1.001(0.998–1.003)	0.418	32.666	0.139
		MR Egger		1.001(0.995–1.006)	0.702	32.666	0.111	-1.368374e-06	0.990
		weighted median		1.007(0.997–1.003)	0.639
	Calculus of gallbladder with acute cholecystitis	Inverse variance weighted	6	0.996(0.992–0.999)	0.038	6.849	0.232
		MR Egger		1.003(0.972–1.036)	0.818	6.476	0.166	-0.0002	0.656
		weighted median		0.995(0.991–0.999)	0.025

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