CV death | Events/Total | Unadjusted | P for Interaction | Adjusted | P for Interaction | ||
---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | ||||
Lp-PLA2 (as a dichotomous variable) | |||||||
Sex | Â | Â | Â | 0.247 | Â | Â | 0.385 |
 Male | 43/223 | 1.68(0.91–3.11) | 0.096 |  | 2.06(1.04–4.08) | 0.038 |  |
 Female | 34/138 | 3.01(1.36–6.67) | 0.007 |  | 3.95(1.68–9.23) | 0.002 |  |
Age | Â | Â | Â | 0.329 | Â | Â | 0.53 |
  ≥ 60 | 57/198 | 2.24(1.29–3.89) | 0.004 |  | 2.65(1.49–4.69) | 0.001 |  |
  < 60 | 20/163 | 2.21(0.85–5.75) | 0.105 |  | 2.70(0.91–7.99) | 0.074 |  |
History of diabetes | Â | 0.313 | Â | Â | 0.205 | ||
 Yes | 27/86 | 3.06(1.34–7.02) | 0.008 |  | 3.99(1.67–9.54) | 0.002 |  |
 No | 50/275 | 1.87(1.04–3.35) | 0.037 |  | 2.21(1.20–4.06) | 0.011 |  |
History of CAD | Â | Â | 0.399 | Â | Â | 0.774 | |
 Yes | 15/37 | 3.27(1.16–9.23) | 0.025 |  | 2.05(0.65–6.50) | 0.221 |  |
 No | 62/324 | 2.26(1.31–3.92) | 0.004 |  | 2.70(1.54–4.73) | 0.001 |  |
LDL-c (mmol/L) | Â | Â | 0.821 | Â | Â | 0.733 | |
  ≥ 2.45 | 36/181 | 2.44(1.01–5.86) | 0.046 |  | 2.68(1.06–6.78) | 0.037 |  |
  < 2.45 | 41/180 | 2.74(1.48–5.07) | 0.001 |  | 3.81(1.88–7.71) |  < 0.001 |  |
HDL-c (mmol/L) | Â | Â | 0.771 | Â | Â | 0.470 | |
  ≥ 1.03 | 39/184 | 1.98(1.03–3.81) | 0.04 |  | 2.04(1.02–4.09) | 0.045 |  |
  < 1.03 | 38/177 | 2.30(1.14–4.63) | 0.02 |  | 3.50(1.65–7.44) | 0.001 |  |
TG (mmol/L) | Â | Â | 0.745 | Â | Â | 0.576 | |
  ≥ 1.29 | 39/182 | 2.39(1.14–5.05) | 0.022 |  | 3.30(1.48–7.37) | 0.004 |  |
  < 1.29 | 38/179 | 2.03(1.06–3.86) | 0.032 |  | 2.43(1.25–4.74) | 0.009 |  |
Lp-PLA2 (as a continuous variable)(per 100U/L) | |||||||
Sex | Â | Â | Â | 0.169 | Â | Â | 0.25 |
 Male | 43/223 | 1.09(0.93–1.28) | 0.271 |  | 1.20(0.99–1.46) | 0.064 |  |
 Female | 34/138 | 1.29(1.09–1.52) | 0.003 |  | 1.33(1.12–1.59) | 0.002 |  |
Age | Â | Â | Â | 0.854 | Â | Â | 0.712 |
  ≥ 60 | 57/198 | 1.19(1.04–1.35) | 0.1 |  | 1.22(1.06–1.40) | 0.006 |  |
  < 60 | 20/163 | 1.21(0.97–1.53) | 0.096 |  | 1.28(0.99–1.65) | 0.053 |  |
History of diabetes | Â | 0.11 | Â | Â | 0.086 | ||
 Yes | 27/86 | 1.47(1.13–1.90) | 0.004 |  | 1.53(1.17–2.01) | 0.002 |  |
 No | 50/275 | 1.16(1.01–1.33) | 0.041 |  | 1.21(1.04–1.41) | 0.015 |  |
History of CAD | Â | Â | 0.379 | Â | Â | 0.688 | |
 Yes | 15/37 | 1.31(0.99–1.74) | 0.059 |  | 1.09(0.73–1.64) | 0.667 |  |
 No | 62/324 | 1.19(1.06–1.35) | 0.007 |  | 1.27(1.11–1.46) | 0.001 |  |
LDL-c (mmol/L) | Â | Â | 0.317 | Â | Â | 0.061 | |
  ≥ 2.45 | 36/181 | 1.15(0.96–1.38) | 0.116 |  | 1.16(0.95–1.42) | 0.135 |  |
  < 2.45 | 41/180 | 1.30(1.12–1.52) | 0.001 |  | 1.62(1.29–2.04) |  < 0.001 |  |
HDL-c (mmol/L) | Â | Â | 0.923 | Â | Â | 0.122 | |
  ≥ 1.03 | 39/184 | 1.17(1.00–1.37) | 0.047 |  | 1.21(1.01–1.46) | 0.043 |  |
  < 1.03 | 38/177 | 1.20(1.01–1.41) | 0.041 |  | 1.33(1.11–1.60) | 0.002 |  |
TG (mmol/L) | Â | Â | 0.574 | Â | Â | 0.879 | |
  ≥ 1.29 | 39/182 | 1.17(1.00–1.36) | 0.048 |  | 1.25(1.05–1.49) | 0.011 |  |
  < 1.29 | 38/179 | 1.25(1.03–1.52) | 0.026 |  | 1.35(1.08–1.68) | 0.008 |  |
MACEs | Events/Total | Unadjusted | P for Interaction | Adjusted | P for Interaction | ||
HR (95% CI) | P | HR (95% CI) | P | ||||
Lp-PLA2 (as a dichotomous variable) | |||||||
Sex | Â | Â | Â | 0.105 | Â | Â | 0.311 |
 Male | 51/223 | 1.35(0.78–2.35) | 0.285 |  | 1.72(0.93–3.18) | 0.087 |  |
 Female | 37/138 | 2.91(1.37–6.17) | 0.005 |  | 3.99(1.78–8.94) | 0.001 |  |
Age | Â | Â | Â | 0.595 | Â | Â | 0.246 |
  ≥ 60 | 67/198 | 1.80(1.10–2.95) | 0.019 |  | 2.10(1.26–3.49) | 0.004 |  |
  < 60 | 21/163 | 2.39(0.93–6.15) | 0.072 |  | 3.10(1.02–9.41) | 0.047 |  |
History of diabetes | Â | 0.352 | Â | Â | 0.282 | ||
 Yes | 29/86 | 2.50(1.16–5.40) | 0.019 |  | 2.77(1.25–6.13) | 0.012 |  |
 No | 59/275 | 1.64(0.97–2.77) | 0.068 |  | 1.97(1.14–3.41) | 0.016 |  |
History of CAD | Â | Â | 0.332 | Â | Â | 0.914 | |
 Yes | 16/37 | 2.81(1.03–7.62) | 0.043 |  | 1.86(0.54–6.43) | 0.325 |  |
 No | 72/324 | 1.88(1.15–3.07) | 0.012 |  | 2.25(1.35–3.75) | 0.002 |  |
LDL-c (mmol/L) | Â | Â | 0.965 | Â | Â | 0.993 | |
  ≥ 2.45 | 42/181 | 2.14(0.99–4.61) | 0.054 |  | 2.39(1.05–5.44) | 0.039 |  |
  < 2.45 | 46/180 | 2.18(1.22–3.88) | 0.008 |  | 2.59(1.36–4.95) | 0.004 |  |
HDL-c (mmol/L) | Â | Â | 0.792 | Â | Â | 0.540 | |
  ≥ 1.03 | 43/184 | 1.71(0.93–3.15) | 0.087 |  | 1.72(0.90–3.29) | 0.102 |  |
  < 1.03 | 45/177 | 1.93(1.04–3.59) | 0.038 |  | 2.77(1.41–5.46) | 0.033 |  |
TG (mmol/L) | Â | Â | 0.956 | Â | Â | 0.739 | |
  ≥ 1.29 | 46/182 | 1.85(0.98–3.52) | 0.059 |  | 2.38(1.19–4.76) | 0.014 |  |
  < 1.29 | 42/179 | 1.80(0.98–3.30) | 0.059 |  | 1.95(1.02–3.75) | 0.044 |  |
Lp-PLA2 (as a continuous variable)(per 100U/L) | Â | Â | Â | Â | |||
Sex | Â | Â | Â | 0.055 | Â | Â | 0.409 |
 Male | 51/223 | 1.03(0.89–1.20) | 0.692 |  | 1.12(0.93–1.34) | 0.24 |  |
 Female | 37/138 | 1.28(1.09–1.51) | 0.002 |  | 1.35(1.13–1.61) |  < 0.001 |  |
Age | Â | Â | Â | 0.343 | Â | Â | 0.804 |
  ≥ 60 | 67/198 | 1.12(0.99–1.27) | 0.065 |  | 1.15(1.01–1.32) | 0.04 |  |
  < 60 | 21/163 | 1.27(1.01–1.59) | 0.038 |  | 1.37(1.03–1.81) | 0.028 |  |
History of diabetes | Â | 0.238 | Â | Â | 0.189 | ||
 Yes | 29/86 | 1.33(1.04–1.71) | 0.022 |  | 1.35(1.04–1.75) | 0.023 |  |
 No | 59/275 | 1.12(0.99–1.28) | 0.073 |  | 1.17(1.02–1.35) | 0.03 |  |
History of CAD | Â | Â | 0.386 | Â | Â | 0.831 | |
 Yes | 16/37 | 1.26(0.96–1.66) | 0.096 |  | 1.15(0.79–1.68) | 0.473 |  |
 No | 72/324 | 1.15(1.02–1.29) | 0.026 |  | 1.26(1.07–1.40) | 0.003 |  |
LDL-c (mmol/L) | Â | Â | 0.398 | Â | Â | 0.246 | |
  ≥ 2.45 | 42/181 | 1.12(0.95–1.33) | 0.170 |  | 1.16(0.97–1.40) | 0.106 |  |
  < 2.45 | 46/180 | 1.24(1.07–1.44) | 0.006 |  | 1.40(1.12–1.74) | 0.003 |  |
HDL-c (mmol/L) | Â | Â | 0.906 | Â | Â | 0.880 | |
  ≥ 1.03 | 43/184 | 1.13(0.97–1.31) | 0.114 |  | 1.15(0.97–1.36) | 0.118 |  |
  < 1.03 | 45/177 | 1.15(0.98–1.34) | 0.079 |  | 1.27(1.07–1.51) | 0.008 |  |
TG (mmol/L) | Â | Â | 0.587 | Â | Â | 0.929 | |
  ≥ 1.29 | 46.182 | 1.12(0.97–1.29) | 0.117 |  | 1.21(1.03–1.42) | 0.018 |  |
  < 1.29 | 42/179 | 1.19(0.99–1.44) | 0.066 |  | 1.22(0.99–1.50) | 0.061 |  |