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Table 6 Optimal cut-off points of baseline information in pregnant women with SCH for predicting pregnancy outcomes

From: The association between dyslipidaemia in the first trimester and adverse pregnancy outcomes in pregnant women with subclinical hypothyroidism: a cohort study

Outcomes

 

AUC (95%CI)

P-values

 

Sensitivity (%)

 

Specificity (%)

 

Youden index

 

Cut-off point

TSH (mIU/L)

           

 Preterm birth

 

0.624(0.535, 0.714)

0.017*

 

64.30

 

35.70

 

0.232

 

4.565

 FGR

 

0.608(0.546, 0.669)

0.001*

 

45.20

 

73.60

 

0.187

 

5.575

FT4 (pmol/L)

           

 Pregnancy loss

 

0.407(0.325, 0.490)

0.029*

 

95.90

 

5.00

 

0.009

 

12.535

TPOAb(U/mL)

           

 Gestational hypertension

 

0.646(0.530, 0.763)

0.026*

 

0.500

 

0.775

 

0.275

 

64.500

 FGR

 

0.602(0.526, 0.678)

0.010*

 

0.700

 

0.474

 

0.174

 

38.650

 Preterm birth

 

0.622(0.503, 0.741)

0.043*

 

0.417

 

0.819

 

0.236

 

97.550

TC (mmol/L)

           

 Gestational hypertension

 

0.638(0.550, 0.725)

0.004*

 

73.00

 

45.00

 

0.279

 

4.300

 Preeclampsia/Eclampsia

 

0.610(0.513, 0.707)

0.023*

 

59.50

 

59.60

 

0.190

 

4.365

 GDM

 

0.585(0.535, 0.635)

0.001*

 

48.30

 

66.50

 

0.148

 

4.475

TG (mmol/L)

           

 Caesarean Section

 

0.564(0.526, 0.603)

0.001*

 

41.40

 

70.40

 

0.119

 

1.195

 Gestational hypertension

 

0.616(0.516, 0.716)

0.017*

 

59.50

 

62.50

 

0.220

 

1.135

 Preeclampsia/Eclampsia

 

0.629(0.531, 0.726)

0.008*

 

40.50

 

86.00

 

0.266

 

1.605

 GDM

 

0.662(0.617, 0.707)

0.000*

 

88.40

 

36.90

 

0.253

 

0.855

 Preterm birth

 

0.613(0.516, 0.711)

0.029*

 

37.50

 

83.70

 

0.212

 

1.535

 Macrosomia

 

0.613(0.538, 0.687)

0.004*

 

50.80

 

71.00

 

0.218

 

1.255

LDL-C (mmol/L)

           

 Gestational hypertension

 

0.637(0.552, 0.722)

0.005*

 

51.40

 

73.90

 

0.252

 

2.575

 Preeclampsia/Eclampsia

 

0.659(0.558, 0.760)

0.001*

 

51.40

 

81.90

 

0.332

 

2.785

 GDM

 

0.593(0.544, 0.643)

0.000*

 

53.70

 

62.60

 

0.164

 

2.335

Age (year)

           

 Caesarean Section

 

0.570(0.523, 0.609)

0.000*

 

31.50

 

79.00

 

0.105

 

33.500

 Pregnancy loss

 

0.653(0.579, 0.727)

0.000*

 

73.50

 

49.60

 

0.231

 

30.500

 GDM

 

0.654(0.604, 0.704)

0.000*

 

55.10

 

71.90

 

0.270

 

32.500

Pre-BMI (kg/m2)

           

 Caesarean Section

 

0.590(0.552, 0.628)

0.000*

 

63.70

 

51.50

 

0.152

 

20.810

 Gestational hypertension

 

0.734(0.655, 0.813)

0.000*

 

88.10

 

62.40

 

0.435

 

22.048

 Preeclampsia/Eclampsia

 

0.632(0.530, 0.733)

0.007*

 

54.10

 

74.50

 

0.286

 

23.530

 GDM

 

0.625(0.576, 0.673)

0.000*

 

66.70

 

54.20

 

0.208

 

21.114

 Preterm birth

 

0.646(0.550, 0.741)

0.005*

 

53.10

 

76.40

 

0.295

 

23.788

  1. Abbreviations: SCH subclinical hypothyroidism; BMI body mass index; TSH thyroid-stimulating hormone; FT4 free thyroxine; TC total cholesterol; TG triglyceride; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol; GDM gestational diabetes mellitus; PROM, premature rupture of fetal membranes; FGR fetal growth restriction. *P-values < 0.05 is considered statistically significant