Table 1 Classification of patients as below or above the 70 mg/dL LDL-C cutpoint by equations
From: An improved method for estimating low LDL-C based on the enhanced Sampson-NIH equation
Parameter | N | Sensitivity | Specificity | PPV | NPV | nMCC |
|---|---|---|---|---|---|---|
TG 400 mg/dL | ||||||
Friedewald | 9483 | 93.4 | 86.1 | 70.8 | 97.3 | 86.8 |
extended Martin | 9483 | 82.0 | 94.1 | 83.4 | 93.5 | 88.2 |
Sampson | 9483 | 88.7 | 92.1 | 80.2 | 95.7 | 89.2 |
enhanced Sampson | 3894 | 92.6 | 96.1 | 89.4 | 97.3 | 93.8 |
TG 800 mg/dL | ||||||
Friedewald | 10373 | 92.8 | 83.5 | 68.3 | 96.8 | 85.2 |
extended Martin | 10373 | 73.4 | 94.5 | 83.6 | 90.3 | 85.4 |
Sampson | 10373 | 86.4 | 91.7 | 80.0 | 94.7 | 88.2 |
enhanced Sampson | 4115 | 92.1 | 95.8 | 89.2 | 97.0 | 93.5 |
TG 1500 mg/dL | ||||||
Friedewald | 10611 | 92.8 | 82.6 | 67.7 | 96.7 | 84.8 |
extended Martin | 10611 | 70.6 | 94.6 | 83.7 | 89.1 | 84.4 |
Sampson | 10611 | 86.1 | 91.2 | 79.4 | 94.4 | 87.8 |
enhanced Sampson | 4193 | 91.9 | 95.6 | 89.0 | 96.8 | 93.3 |