From: Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy
Target | Drugs | Tumors | mechanisms | Clinical trials |
---|---|---|---|---|
CD36 | JC61.3 | oral cancer gastric cancer | inhibit FA and LDL protein uptake; prevents lipid droplet formation | N/A [104] |
FA6.152 | oral cancer | prevent lipid droplet formation | N/A [1] | |
SSO | cervical cancer | inhibit FA uptake | N/A [105] | |
FABP | SBFI-26 | prostate cancer | inhibit lipogenesis | N/A [1] |
BMS3094013 | ovarian cancer | inhibit lipogenesis | N/A [106] | |
FASN | Orlistat | prostate cancer NSCLC | induce lipid peroxidation and ferroptosis | N/A [107] |
TVB-3166 | lung cancer ovarian cancer prostate cancer HCC | promote tumor cell apoptosis | N/A [108] | |
TVB-3664 | colon cancer lung cancer | promote tumor cell apoptosis | N/A [108] | |
TVB2640 | ovarian cancer breast cancer | reduce hepatic fat | NCT03808558 NCT02223247 NCT02980029 NCT03179904 NCT03032484 | |
Fasnall | breast cancer | promote apoptosis | N/A [109] | |
ACLY | ECT-1002 | HCC | inhibit lipogenesis | NCT05687071 NCT05683340 NCT04784442 [110] |
SB-204990 | ovarian cancer | inhibiting ACLY and activate the AMPK-ROS pathway | N/A [110] | |
ACC | PF-05221304 | - | reduce liver fat | N/A [111] |
ND-646 | NSCLC | inhibite fatty acid synthesis | N/A [111] | |
ND-654 | HCC | inhibit lipogenesis | N/A [112] | |
SCD1 | A939572 | lung cancer ovarian cancer | induce endoplasmic reticulum stress; inhibit epithelial-mesenchymal transition; inhibit EGFR/PI3K/AKT signaling | N/A [113] |
MF-438 | NSCLC ovarian cancer melanoma | downregulate YAP/TAZ | N/A [1] | |
MK-8245 | - | - | NCT00972322 [117] | |
CAY10566 | - | activate the AMPK pathway and lipophagocytosis | N/A [114] | |
DGAT1 | A922500 | cervical cancer HCC | inhibit triglyceride synthesis | N/A [115] |
AZD3988 | prostate cancer | decrease TAG synthesis | N/A [1] | |
AZD7687 | - | reduced circulating TAG | NCT01217905 [116] | |
DGAT2 | PF-06424439 | gastric cancer breast cancer | prevents LD formation | N/A [1] |
JNJ-DGAT2-A/B | - | inhibit TG synthesis | N/A [1] |