Table 2 A GRADE summary of the protective effect of APN on MIRI
Outcomes | Summary of finding | Relative effect (95% CI) | Limitations | Inconsistency | Indirectness | Imprecision | Publication bias | Quality | |
|---|---|---|---|---|---|---|---|---|---|
MIRI group | APN group | ||||||||
Infarct size | 171 animals in 15 studies | 169 animals in 15 studies | WMD, 16.67 (13.18, 20.16) | + | − | + | + | + | ⨁⨁⨁◯, Moderate |
LVEDP | 99 animals in 9 studies | 98 animals in 9 studies | WMD, 5.96 (4.23, 7.70) | − | − | + | + | − | ⨁◯◯◯, Critically low |
+ dp/dtmax | 107 animals in 9 studies | 107 animals in 9 studies | WMD, 1393.59 (972.57, 1814.60) | + | − | + | + | − | ⨁⨁◯◯, Low |
-dp/dtmax | 68 animals in 7 studies | 68 animals in 7 studies | WMD, 850.06 (541.22, 1158.90) | + | − | + | + | + | ⨁⨁⨁◯, Moderate |
LVEF | 68 animals in 5 studies | 68 animals in 5 studies | WMD, 9.96 (7.29, 12.63) | + | − | + | + | + | ⨁⨁⨁◯, Moderate |
Caspase-3 | 126 animals in 12 studies | 126 animals in 12 studies | SMD, 3.86 (2.97, 4.76) | − | − | + | + | − | ⨁◯◯◯, Critically low |
Apoptotic rate | 95 animals in 9 studies | 95 animals in 9 studies | WMD, 13.10 (8.15, 18.05) | − | − | + | + | + | ⨁⨁◯◯, Low |
SOD | 24 animals in 3 studies | 24 animals in 3 studies | SMD, 1.91 (1.17, 2.65) | − | + | + | + | − | ⨁⨁◯◯, Low |
LDH | 70 animals in 6 studies | 70 animals in 6 studies | SMD, 2.82 (1.60, 4.04) | − | − | + | + | − | ⨁◯◯◯, Critically low |
TNF-α | 13 animals in 2 studies | 13 animals in 2 studies | SMD, 4.23 (2.48, 5.98) | − | + | + | + | − | ⨁⨁◯◯, Low |
Superoxide production | 43 animals in 4 studies | 43 animals in 4 studies | SMD, 4.53 (2.39, 6.67) | − | − | + | + | − | ⨁◯◯◯, Critically low |