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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells

Fig. 1

Genomic landscape of the 5’ flanking region of DIO1 gene. From the top: HiC data from Liver_STL011 in 3D Genome browser (http://3dgenome.fsm.northwestern.edu/). The AS-SNP rs2294510 is marked by a vertical line. The two guide RNAs (gRNA-1 and gRNA-2) used in the study. A promoter (red) and enhancer (yellow) candidate cis regulatory elements (cCREs) and transcription factors binding sites from ChIP-seq experiments in HepG2 cells (black annotations) or liver (magenta annotation) defined in ENCODE3

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Lipids in Health and Disease

ISSN: 1476-511X