Table 1 Main features of alcoholic and nonalcoholic fatty liver disease at histology
From: What are the common downstream molecular events between alcoholic and nonalcoholic fatty liver?
Alcoholic Liver Disease | Non Alcoholic Fatty Liver Disease |
|---|---|
Macrovescicular steatosis is largely represented | Macrovescicular steatosis is less represented |
Mallory hyaline is recurrent | Mallory hyaline is not occurring often |
Swollen hepatocytes/Ballooned cells are more frequent | Swollen hepatocytes/Ballooned cells are less present |
Lobular infiltration of polymorphonuclear leukocytes (neutrophils) is severe | Usually, there is mild lobular infiltration with foci of mononuclear cell clusters, and occasional eosinophils or neutrophils. |
Inflammatory cell infiltration is more pronounced | Inflammatory cell infiltration is less marked |
Perivenular fibrosis with the chicken wire” pattern of fibrosis is common | Fibrosis typically begins in zone 3 with the characteristic pericellular “chicken wire” pattern |
Fibro-obliterative/inflammatory lesions of the outflow veins, alcoholic foamy degeneration are present | Fibro-obliterative lesions are not constant and foamy degeneration is rare |
Acute cholestasis is often present | Intrahepatic cholestasis is associated with more advanced histological impairment |
Phlebosclerosis, and (less commonly) lymphocytic phlebitis are present | Phlebosclerosis is rare |
There is solid fibrosis | There is lattice fibrosis |
Megamitochondria, bile stasis, hemosiderin deposition, vacuolic nuclei, and lipogranuroma are scarcely represented | Megamitochondria, bile stasis, hemosiderin deposition, vacuolic nuclei, and lipogranuroma are more often represented |
Bridging necrosis is frequent | Bridging necrosis is rare |
Fibrosis/cirrhosis is more frequent | Fibrosis/cirrhosis is less frequent |