Table 2 Impact of CDKAL1 genetic variants and low HDL on T2D risk factors among older adults: Stepwise logistic regression and UK Biobank replication

Study

SNPs ± Low HDL

OR

C.I.2.5%

C.I.97.5%

P.value

T2D.vs. noT2D aged ≥ 60

rs10946403GA

1.44

1.21

1.73

< 0.001

T2D.vs.noT2D aged ≥ 60

rs10946403GG

1.62

1.17

2.25

< 0.001

T2D.vs.noT2D aged ≥ 60

rs10946403GA.low HDL

1.48

1.23

1.78

< 0.001

T2D.vs.noT2D aged ≥ 60

rs10946403GG.low HDL

1.68

1.22

2.35

< 0.001

T2D.vs.noT2D aged ≥ 65

rs10946403GA

1.54

1.27

1.88

< 0.001

T2D.vs.noT2D aged ≥ 65

rs10946403GG

1.65

1.17

2.37

0.01

T2D.vs.noT2D aged ≥ 65

rs10946403GA.low HDL

1.57

1.28

1.92

< 0.001

T2D.vs.noT2D aged ≥ 65

rs10946403GG.low HDL

1.71

1.20

2.47

< 0.001

T2D.vs.noT2D aged ≥ 70

rs10946403GA

1.57

1.25

1.97

< 0.001

T2D.vs.noT2D aged ≥ 70

rs10946403GG

2.00

1.32

3.14

< 0.001

T2D.vs.noT2D aged ≥ 70

rs10946403GA.low HDL

1.60

1.27

2.01

< 0.001

T2D.vs.noT2D aged ≥ 70

rs10946403GG.low HDL

2.06

1.34

3.24

< 0.001

T2D.vs.noT2D aged ≥ 60

rs4712523GA

1.42

1.18

1.70

< 0.001

T2D.vs.noT2D aged ≥ 60

rs4712523GG

1.74

1.30

2.33

< 0.001

T2D.vs.noT2D aged ≥ 60

rs4712523GA.low HDL

1.45

1.20

1.74

< 0.001

T2D.vs.noT2D aged ≥ 60

rs4712523GG.low HDL

1.78

1.33

2.40

< 0.001

T2D.vs.noT2D aged ≥ 65

rs4712523GA

1.45

1.19

1.77

< 0.001

T2D.vs.noT2D aged ≥ 65

rs4712523GG

1.77

1.29

2.45

< 0.001

T2D.vs.noT2D aged ≥ 65

rs4712523GA.low HDL

1.47

1.20

1.79

< 0.001

T2D.vs.noT2D aged ≥ 65

rs4712523GG.low HDL

1.81

1.31

2.51

< 0.001

T2D.vs.noT2D aged ≥ 70

rs4712523GA

1.47

1.17

1.84

< 0.001

T2D.vs.noT2D aged ≥ 70

rs4712523GG

2.08

1.43

3.10

< 0.001

T2D.vs.noT2D aged ≥ 70

rs4712523GA.low HDL

1.49

1.18

1.87

< 0.001

T2D.vs.noT2D aged ≥ 70

rs4712523GG.low HDL

2.11

1.44

3.16

< 0.001

T2D.vs.noT2D aged ≥ 60

rs7756992GA

1.44

1.20

1.73

< 0.001

T2D.vs.noT2D aged ≥ 60

rs7756992GG

1.81

1.34

2.46

< 0.001

T2D.vs.noT2D aged ≥ 60

rs7756992GA.low HDL

1.49

1.24

1.79

< 0.001

T2D.vs.noT2D aged ≥ 60

rs7756992GG.low HDL

1.89

1.39

2.58

< 0.001

T2D.vs.noT2D aged ≥ 65

rs7756992GA

1.46

1.20

1.78

< 0.001

T2D.vs.noT2D aged ≥ 65

rs7756992GG

1.83

1.32

2.57

< 0.001

T2D.vs.noT2D aged ≥ 65

rs7756992GA.low HDL

1.49

1.22

1.82

< 0.001

T2D.vs.noT2D aged ≥ 65

rs7756992GG.low HDL

1.90

1.36

2.68

< 0.001

T2D.vs.noT2D aged ≥ 70

rs7756992GA

1.44

1.15

1.81

< 0.001

T2D.vs.noT2D aged ≥ 70

rs7756992GG

2.12

1.43

3.22

< 0.001

T2D.vs.noT2D aged ≥ 70

rs7756992GA.low HDL

1.46

1.17

1.84

< 0.001

T2D.vs.noT2D aged ≥ 70

rs7756992GG.low HDL

2.20

1.47

3.35

< 0.001

Study

SNPs

OR

C.I.2.5%

C.I.97.5%

P.value

T2D.vs.noT2D aged ≥ 65

rs4712523GA

1.04

1.00

1.08

0.05

T2D.vs.noT2D aged ≥ 65

rs4712523GG

1.18

1.11

1.26

< 0.001

T2D.vs.noT2D aged ≥ 65

rs4712523GA.low HDL

1.04

1.00

1.08

0.07

T2D.vs.noT2D aged ≥ 65

rs4712523GG.low HDL

1.19

1.11

1.27

< 0.001

T2D.vs.noT2D aged ≥ 70

rs4712523GA

0.95

0.81

1.11

0.53

T2D.vs.noT2D aged ≥ 70

rs4712523GG

1.38

1.04

1.85

0.03

T2D.vs.noT2D aged ≥ 70

rs4712523GA.low HDL

0.94

0.81

1.11

0.48

T2D.vs.noT2D aged ≥ 70

rs4712523GG.low HDL

1.38

1.04

1.86

0.03

T2D.vs.noT2D aged ≥ 65

rs7756992GA

1.06

1.02

1.10

< 0.001

T2D.vs.noT2D aged ≥ 65

rs7756992GG

1.28

1.20

1.38

< 0.001

T2D.vs.noT2D aged ≥ 65

rs7756992GA.low HDL

1.06

1.02

1.10

0.01

T2D.vs.noT2D aged ≥ 65

rs7756992GG.low HDL

1.29

1.20

1.38

< 0.001

T2D.vs.noT2D aged ≥ 70

rs7756992GA

1.05

0.90

1.24

0.52

T2D.vs.noT2D aged ≥ 70

rs7756992GG

1.46

1.07

2.03

0.02

T2D.vs.noT2D aged ≥ 70

rs7756992GA.low HDL

1.05

0.90

1.23

0.55

T2D.vs.noT2D aged ≥ 70

rs7756992GG.low HDL

1.46

1.07

2.03

0.02