Table 1 Characteristics of the study population
COHORT 6–8 | COHORT 9–13 | P-value ‡ | |||||||
|---|---|---|---|---|---|---|---|---|---|
Sex | Total | p-value † | Sex | Total | p-value † | ||||
Boys | Girls | Boys (N = 88) | Girls (N = 64) | ||||||
(N = 111) | (N = 93) | ||||||||
Age Mean (SD) | 6.58 (0.51) | 6.59 (0.51) | 6.58 (0.51) | ns* | 11.31(1.03) | 11.52 (1.05) | 11.40(1.04) | ns* | < 0.0001* |
BMI Mean (SD) | 15.59 (1.10) | 15.70 (1.32) | 15.64 (1.20) | ns* | 17.63 (2.37) | 17.98 (2.33) | 17.78 (2.36) | ns* | < 0.0001* |
Ethnicity | ns*** | ||||||||
African | 3 | 0 | 3 (1%) | ns*** | 0 | 0 | 0 (0%) | ns*** | |
Caucasian | 106 | 91 | 197 (97%) | ns*** | 84 | 63 | 147 (97%) | ns*** | ns*** |
Latin | 1 | 2 | 3 (1%) | ns*** | 2 | 1 | 3 (2%) | ns*** | ns*** |
South-Asian | 1 | 0 | 1 (0.5%) | ns*** | 2 | 0 | 2 (1%) | ns*** | ns*** |
Gestational age at delivery Mean (SD) | 38.93 (1.58) | 39.27 (1.21) | 39.08 (1.43) | ns* | 38.84 (1.54) | 39.42 (1.32) | 39.04 (1.48) | ns* | ns* |
Tanner Stage | |||||||||
1 | 111 | 93 | 204 (100%) | ns*** | 43 | 13 | 56 (37%) | < 0.001*** | < 0.0001*** |
2 | – | – | – | 18 | 21 | 39 (26%) | ns | ||
3 | – | – | – | 20 | 19 | 39 (26%) | ns | ||
4 | – | – | – | 4 | 9 | 13 (9%) | ns | ||
5 | – | – | – | 2 | 2 | 4 (3%) | ns | ||
Lipid Profile Mean (SD) | |||||||||
TC (mmol/L) | 3.75 (0.57) | 3.75 (0.56) | 3.75 (0.56) | ns** | 4.04 (0.63) | 4.06 (0.56) | 4.05 (0.60) | ns** | < 0.0001** |
HDL-C (mmol/L) | 0.68 (0.24) | 0.60 (0.21) | 0.65 (0.23) | < 0.01** | 1.56 (0.28) | 1.50 (0.31) | 1.54 (0.30) | ns* | < 0.0001* |
TG (mmol/L) | 0.96 (0.45) | 1.06 (0.54) | 1.01 (0.49) | ns* | 1.10 (0.63) | 1.15 (0.60) | 1.12 (0.62) | ns* | ns* |
LDL-C(mmol/L) | 2.63 (0.56) | 2.72 (0.54) | 2.67 (0.55) | ns** | 1.93 (0.51) | 2.10 (0.42) | 2.00 (0.48) | ns** | < 0.0001** |
Non-HDL-C (mmol/L) | 3.06 (0.58) | 3.15 (0.56) | 3.10 (0.57) | ns** | 2.47 (0.62) | 2.56 (0.54) | 2.51 (0.59) | ns* | < 0.0001** |
ApoB (g/L) | – | – | – | – | 0.70 (0.15) | 0.71 (0.13) | 0.71 (0.14) | ns* | – |