Table 3 The mediation effect of NAFLD on cortical construction via liver fat, LDL cholesterol and AST
Exposure-Outcome | Mediator | Total effect Beta (95% CI) | Direct effect A Beta (95% CI) | Direct effect B Beta (95% CI) | Mediation effect Beta (95% CI) | Mediated P value |
|---|---|---|---|---|---|---|
NAFLD-Parahippocampal SA (global weighting ) | Percent liver fat | -4.919 (-9.023, -0.814) | 0.786 (0.722, 0.850) | -6.064 (-9.939, -2.190) | -4.766 (-7.836, -1.697) | 0.002 |
NAFLD-Cuneus TH (global weighting ) | Percent liver fat | -0.006 (-0.012, -0.001) | 0.786 (0.722, 0.850) | -0.008 (-0.013, -0.002) | -0.006 (-0.010, -0.002) | 0.007 |
NAFLD-Caudalmiddlefrontal TH (non-global weighting ) | LDL cholesterol | -0.008 (-0.016, -0.001) | -0.026 (-0.043, -0.009) | 0.0111 (0.004, 0.019) | -0.0003 (-5.650E-04, -1.390E-05) | 0.040 |
NAFLD-Parstriangularis TH (non-global weighting ) | Percent liver fat | -0.009 (-0.016, -0.001) | 0.786 (0.722, 0.850) | -0.009 (-0.016, -0.002) | -0.007 (-0.013, -0.001) | 0.017 |
NAFLD-Parstriangularis TH (non-global weighting ) | AST | -0.009 (-0.016, -0.001) | 3.529 (3.321, 3.737) | -0.002 (-0.003, -0.001) | -0.007 (-0.011, -0.002) | 0.002 |