Table 1 Baseline Demographics and Clinical Characteristics
Characteristics | Total (n = 72) | Placebo (n = 35) | Orlistat (n = 37) | P value |
|---|---|---|---|---|
General data | ||||
Age at entry study (years) | 37.00 (30.00,41.00) | 37.00 (33.00,41.00) | 37.00 (29.00,41.00) | 0.685 |
BMI (kg/m2) | 29.36 (28.38,32.39) | 29.22 (27.93,31.41) | 30.33 (28.77,33.29) | 0.366 |
WC (cm) | 102.90 (99.63,108.40) | 101.50 (98.80,107.80) | 103.60 (100.15,111.40) | 0.485 |
Body fat (kg) | 27.95 (24.55,30.80) | 26.20 (24.05,30.65) | 28.15 (25.65,31.18) | 0.419 |
Body muscle (kg) | 59.80 (56.50,66.23) | 59.80 (55.90,66.23) | 60.10 (56.70,66.98) | 0.918 |
Blood chemistry parameters | ||||
TC (mmol/L) | 5.29 ± 0.92 | 5.17 ± 0.87 | 5.41 ± 0.97 | 0.289 |
HDL (mmol/L) | 1.02 ± 0.15 | 0.99 ± 0.15 | 1.04 ± 0.16 | 0.137 |
LDL (mmol/L) | 3.48 ± 0.73 | 3.34 ± 0.68 | 3.62 ± 0.77 | 0.106 |
TG (mmol/L) | 2.49 ± 1.09 | 2.47 ± 0.94 | 2.52 ± 1.23 | 0.844 |
Glucose (mmol/L) | 5.09 ± 0.49 | 5.09 ± 0.49 | 5.09 ± 0.50 | 0.964 |
HbA1c (%) | 5.50 (5.20,5.80) | 5.40 (5.18,5.80) | 5.50 (5.30,5.90) | 0.732 |
FINS (uU/ml) | 19.96 (14.81,31.00) | 19.50 (13.18,31.00) | 21.68 (14.98,33.81) | 0.520 |
Fasting C peptide (ng/ml) | 3.51 (2.68,4.93) | 3.42 (2.64,4.71) | 3.55 (2.71,5.03) | 0.441 |
HOMA-IR | 3.15 (1.64,6.37) | 2.86 (1.66,6.19) | 3.78 (1.64,6.40) | 0.606 |
ALT (U/L) | 55.11 ± 33.04 | 52.82 ± 35.89 | 57.33 ± 30.35 | 0.569 |
AST (U/L) | 25.20 (19.30,36.20) | 20.50 (18.28,34.55) | 29.60 (21.65,37.20) | 0.534 |
e-GFR (ml/min/1.73m2) | 109.85 (93.95,115.13) | 105.70 (93.5,115.2) | 111.50 (94.05,116.90) | 0.451 |
Creatinine (µmol/L) | 77.00 (73.00,88.00) | 80.00 (76.00,89.00) | 75.50 (71.00,84.75) | 0.353 |
Urea (mmol/L) | 4.45 ± 1.08 | 4.36 ± 1.22 | 4.54 ± 0.93 | 0.492 |
Uric acid (mg/dl) | 9.52 ± 1.60 | 9.51 ± 1.51 | 9.53 ± 1.81 | 0.956 |
FibroScan | ||||
E (kPa) | 5.40 (4.60,6.90) | 5.25 (4.60,6.18) | 5.50 (4.65,7.65) | 0.352 |
CAP (dB/m) | 367.00 (316.00,385.00) | 341.50 (309.00,382.50) | 372.00 (334.00,386.50) | 0.324 |
Joint ultrasound | ||||
Aggregates | 3.67 ± 3.88 | 3.61 ± 3.90 | 3.73 ± 3.91 | 0.905 |
Double contour sign | 1.15 ± 2.67 | 1.10 ± 2.68 | 1.20 ± 2.71 | 0.945 |
Tophus | 1.15 ± 2.99 | 1.13 ± 3.00 | 1.17 ± 3.04 | 0.961 |
History of HUA | ||||
Duration of HUA (years) | 6.00 (3.00,10.00) | 6.00 (3.00,13.00) | 5.50 (2.25,9.75) | 0.847 |
The highest uric acid before (µmol/L) | 628.01 ± 93.97 | 630.03 ± 94.57 | 626.22 ± 94.74 | 0.869 |
Patients with gout | 55 (76.39%) | 26 (74.29%) | 29 (78.38%) | |
Duration of gout (years) | 5.00 (2.00,13.00) | 6.00 (2.00,13.00) | 5.00 (2.00,11.00) | 0.583 |
The number of gout flares before treatment 1 year (times) | 1.00 (1.00,3.00) | 1.00 (1.00,3.00) | 1.00 (1.00,3.00) | 0.877 |
Smoke | 23 (31.94%) | 11 (31.43%) | 12 (32.43%) | 0.855 |
Alcohol | 32 (44.44%) | 15 (42.86%) | 17 (45.95%) | 0.977 |
Sweet drinks | ||||
Occasionally | 31 (43.06%) | 15 (42.86%) | 16 (43.24%) | 0.972 |
Yes | 15 (20.83%) | 8 (22.86%) | 7 (18.92%) | 0.815 |