Table 2 Core targets calculated based on multiple algorithms
From: Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway
Category | Rank methods in CytoHubba | |||||
|---|---|---|---|---|---|---|
Degree | MCC | MNC | EPC | Closeness | Betweenness | |
1 | ALB | CASP3 | ALB | AKT1 | ALB | ALB |
2 | AKT1 | SRC | AKT1 | ALB | AKT1 | AKT1 |
3 | CASP3 | HSP90AA1 | CASP3 | IGF1 | EGFR | EGFR |
4 | EGFR | ALB | SRC | SRC | CASP3 | PPARG |
5 | SRC | EGFR | MMP9 | CASP3 | SRC | CASP3 |
6 | MMP9 | IGF1 | EGFR | EGFR | MMP9 | SRC |
7 | IGF1 | AKT1 | IGF1 | MMP9 | IGF1 | MMP9 |
8 | HSP90AA1 | MMP9 | PPARG | HSP90AA1 | PPARG | G6PD |
9 | PPARG | MAPK14 | HSP90AA1 | PPARG | HSP90AA1 | HSP90AA1 |
10 | ESR1 | MAPK8 | ESR1 | ESR1 | ESR1 | ESR1 |