General information | Sacubitril/valsartan (n = 106) | Valsartan (n = 106) | P |
---|---|---|---|
Age (years)a | 69.50 ± 11.88 | 69.04 ± 13.09 | 0.788 |
Gender [n(%)] | Â | Â | 0.773 |
    Male | 68(64.2%) | 70(66.0%) |  |
    Female | 38(35.8%) | 36(34.0%) |  |
SBP (mmHg) a | 146.35 ± 20.19 | 148.27 ± 26.53 | 0.553 |
DBP (mmHg) a | 82.01 ± 13.18 | 82.57 ± 13.78 | 0.764 |
BMI (kg/m2) a | 25.01 ± 3.63 | 25.01 ± 3.33 | 0.997 |
Past history [n(%)] | Â | Â | Â |
    Hypertension | 67(63.2) | 78(73.6) | 0.104 |
    Diabetes | 50(47.2) | 47(44.3) | 0.679 |
    Coronary artery disease | 69(65.1) | 60(56.6) | 0.205 |
    Hyperlipidemia | 53(50.0) | 55(51.9) | 0.783 |
Medication history [n(%)] | Â | Â | Â |
    Beta-blockers | 78(73.6) | 71(67.0) | 0.293 |
    Calcium channel blocker | 39(36.8) | 45(42.5) | 0.400 |
    Diuretics | 71(67.0) | 65(61.3) | 0.390 |
    Aldosterone antagonists | 54(50.9) | 56(52.8) | 0.783 |
    SGLT2-i | 27(25.5) | 23(21.7) | 0.518 |
    Insulin | 31(29.2) | 30(28.3) | 0.879 |
    Hormone | 6(5.7) | 2(1.9) | 0.280 |
    Ezetimibe | 6(5.7) | 5(4.7) | 0.757 |
   Statins | 79(74.5) | 87(82.1) | 0.183 |
NYHA class [n(%)] | Â | Â | 0.372 |
    Class II | 27(25.5) | 21(19.8) |  |
    Class III | 59(55.7) | 69(65.1) |  |
    Class IV | 20(18.9) | 16(15.1) |  |
TG (mmol/L)b | 1.87(1.65,2.32) | 1.84(1.35,2.36) | 0.254 |
TC (mmol/L) a | 4.46 ± 1.28 | 4.51 ± 1.35 | 0.780 |
HDL-C (mmol/L) a | 1.10 ± 0.31 | 1.13 ± 0.33 | 0.528 |
LDL-C (mmol/L) a | 2.60 ± 1.04 | 2.68 ± 1.15 | 0.589 |
ApoA (mmol/L) a | 1.12 ± 0.25 | 1.13 ± 0.24 | 0.809 |
ApoB (mmol/L) a | 0.87 ± 0.28 | 0.89 ± 0.3 | 0.648 |
Albumin(g/L) a | 39.57 ± 7.04 | 40.4 ± 5.69 | 0.349 |
Creatinine (umol/L)b | 115.00(101.00,153.00) | 123.00(106.00,159.00) | 0.186 |
eGFR (mL/min)b | 49.62(34.76,58.65) | 46.45(36.09,55.14) | 0.294 |
Cystatin C (mg/L) b | 1.56(1.34,1.96) | 1.45(1.22,1.96) | 0.254 |
Uric acid (umol/L)b | 441.50(357.00,542.25) | 444.00(338.00,530.50) | 0.712 |
Urea (mmol/L) b | 9.75(7.60,13.93) | 9.49(7.20,13.60) | 0.633 |
FBG (mmol/L) a | 6.85 ± 2.76 | 6.60 ± 2.70 | 0.517 |
HbA1c(%)a | 7.01 ± 1.77 | 6.96 ± 1.53 | 0.835 |
Potassium (mmol/L) a | 4.18 ± 0.42 | 4.20 ± 0.38 | 0.674 |
High-sensitive troponin T (ng/L) b | 32.05(21.51,50.28) | 31.47(23.25,42.15) | 0.923 |
NT-proBNP (pg/mL) b | 3607.10(1912.00,6388.30) | 3006.50(1179.59,7190.28) | 0.306 |
LVEF(%)a | 45.11 ± 10.62 | 46.63 ± 11.14 | 0.311 |
LVEDD (mm) a | 59.76 ± 9.32 | 58.57 ± 9.28 | 0.349 |
LAD (mm) a | 46.02 ± 7.17 | 44.73 ± 7.21 | 0.192 |