Indexes | Times | Sacubitril/valsartan (n = 106) | Valsartan (n = 106) | P |
---|---|---|---|---|
TC (mmol/L) a | Before | 4.46 ± 1.28 | 4.51 ± 1.35 | 0.780 |
16 weeks | 3.68 ± 1.12*** | 3.96 ± 1.36*** | 0.096 | |
TG (mmol/L) b,c | Before | 1.87(1.65,2.32) | 1.84(1.35,2.36) | 0.254 |
16 weeks | 1.13(0.84,1.55)*** | 1.47(1.15,2.01)*** | < 0.001 | |
HDL-C (mmol/L) a | Before | 1.10 ± 0.31 | 1.13 ± 0.33 | 0.528 |
16 weeks | 1.24 ± 0.33*** | 1.13 ± 0.34 | 0.023 | |
LDL-C (mmol/L) a | Before | 2.60 ± 1.04 | 2.68 ± 1.15 | 0.589 |
16 weeks | 2.05 ± 0.90*** | 2.17 ± 1.03*** | 0.338 | |
ApoA (mmol/L) a | Before | 1.12 ± 0.25 | 1.13 ± 0.24 | 0.809 |
16 weeks | 1.23 ± 0.27*** | 1.15 ± 0.26 | 0.030 | |
ApoB (mmol/L) a | Before | 0.87 ± 0.28 | 0.89 ± 0.30 | 0.648 |
16 weeks | 0.75 ± 0.26*** | 0.82 ± 0.28** | 0.066 | |
ΔTG (mmol/L) b,c | Decrease from baseline | 0.84(0.40,1.14) | 0.27(−0.11,0.69) | < 0.001 |