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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Appraising associations between signature lipidomic biomarkers and digestive system cancer risk: novel evidences from a prospective cohort study of UK Biobank and Mendelian randomization analyses

Fig. 5

Phenotypic and genetic association analyses of signature lipidomic biomarkers with the risk of DSCs. Phenotypic association analyses were adjusted with age, sex, BMI, smoking status, alcohol drinking status, education qualification, employment status, TDI, physical activity level, medication use, family cancer history, ALT, AST, SBP, DBP, primary hypertension, cerebral infarction, ischaemic heart disease, HbA1c, and diabetes. Linear one- and two-sample MR analyses were both adjusted with age, sex, assessment centers, genotyping array and the first 10 PCs. HRs (HDL-C: black squares, LDL-C: blue squares; TG: orange squares) with 95% Cis for oesophagus, stomach, colorectal, liver, gallbladder, and pancreas cancers per 1 mmol/L increase of HDL-C, LDL-C, and TG concentrations. P value of 0.008 (0.05/6 outcomes, Bonferroni-adjusted P) was defined as the threshold for remarkable statistical significance. P value between 0.008 and 0.05 was defined as suggestive statistical significance

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Lipids in Health and Disease

ISSN: 1476-511X