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Table 1 Demographic characteristics of all participants with and without DSCs

From: Appraising associations between signature lipidomic biomarkers and digestive system cancer risk: novel evidences from a prospective cohort study of UK Biobank and Mendelian randomization analyses

Characteristics

All participants

(N=319,568)

Without digestive system cancers

(N=312,652)

Digestive system cancersa (N=6916)

Ptrend

HDL-C (mmol/L)

1.409 [1.181;1.685]

1.410 [1.182;1.686]

1.358 [1.135;1.635]

<0.001

LDL-C (mmol/L)

3.536 [2.965;4.135]

3.536 [2.967;4.136]

3.508 [2.888;4.111]

<0.001

TG (mmol/L)

1.481 [1.046;2.138]

1.478 [1.044;2.134]

1.621 [1.140;2.321]

<0.001

Age (years)

58 [50;63]

58 [50;63]

62 [58;66]

0.000

Sex, n (%)

   

<0.001

 Female

173,073 (54.158%)

170,089 (54.402%)

2984 (43.146%)

 

 Male

146495 (45.842%)

142563 (45.598%)

3932 (56.854%)

 

BMI (kg/m2)

26.655 [24.089;29.750]

26.638 [24.076;29.728]

27.367 [24.794;30.504]

<0.001

Smoking status, n (%)

   

<0.001

 Never

173,465 (54.281%)

170,425 (54.509%)

3040 (43.956%)

 

 Previous

113,615 (35.553%)

110,571 (35.366%)

3044 (44.014%)

 

 Current

32,488 (10.166%)

31,656 (10.125%)

832 (12.030%)

 

Alcohol drinking status, n (%)

   

0.002

 Never

10,036 (3.140%)

9801 (3.135%)

235 (3.398%)

 

 Previous

10,494 (3.284%)

10,219 (3.268%)

275 (3.976%)

 

 Current

299,038 (93.576%)

292,632 (93.597%)

6406 (92.626%)

 

Education qualification, n (%)

   

0.262

 None

55,338 (17.317%)

54,142 (17.317%)

1196 (17.293%)

 

 NVQ/CSE/O/A levels

143,063 (44.768%)

140,027 (44.787%)

3036 (43.898%)

 

 Professional/college or university degree

121,167 (37.916%)

118,483 (37.896%)

2684 (38.809%)

 

Employment status, n (%)

   

<0.001

 None employed

134,924 (42.221%)

130,912 (41.871%)

4012 (58.010%)

 

 Current employed

184,644 (57.779%)

181,740 (58.129%)

2904 (41.990%)

 

Medication useb, n (%)

   

<0.001

 None

219,136 (68.573%)

214,976 (68.759%)

4160 (60.150%)

 

 Yes

100,432 (31.427%)

97,676 (31.241%)

2756 (39.850%)

 

TDI

-2.305 [-3.710;0.134]

-2.305 [-3.711;0.131]

-2.283 [-3.669;0.348]

0.023

Physical activity level, n (%)

   

0.066

 None

18,014 (5.637%)

17,580 (5.623%)

434 (6.275%)

 

 Light/Moderate activity

252,040 (78.869%)

246,619 (78.880%)

5421 (78.383%)

 

 Heavy/Strenuous activity

49,514 (15.494%)

48,453 (15.497%)

1061 (15.341%)

 

Family cancer history, n (%)

   

<0.001

 None

219,398 (68.655%)

214,870 (68.725%)

4528 (65.471%)

 

 Yes

100,170 (31.345%)

97,782 (31.275%)

2388 (34.529%)

 

Fasting time (hours)

4 [4;5]

4 [4;5]

4 [4;5]

1.000

ALT (U/L)

24.300 [21.000;28.600]

24.300 [21.000;28.600]

24.900 [21.400;29.200]

<0.001

AST (U/L)

20.000 [15.340;27.090]

19.990 [15.330;27.070]

20.740 [15.818;27.490]

<0.001

SBP (mmHg)

138 [126;152]

138 [126;152]

143 [130;156]

<0.001

DBP (mmHg)

82 [75;89]

82 [75;89]

83 [76;90]

<0.001

Cerebral infarction, n (%)

   

<0.001

 None

312,384 (97.752%)

305,740 (97.789%)

6644 (96.067%)

 

 Yes

7184 (2.248%)

6912 (2.211%)

272 (3.933%)

 

Ischaemic heart disease, n (%)

   

<0.001

 None

289,703 (90.655%)

283,787 (90.768%)

5916 (85.541%)

 

 Yes

29,865 (9.345%)

28,865 (9.232%)

1000 (14.459%)

 

Primary hypertension, n (%)

   

<0.001

 None

226,576 (70.901%)

222,979 (71.319%)

3597 (52.010%)

 

 Yes

92,992 (29.099%)

89,673 (28.681%)

3319 (47.990%)

 

HbA1c (mmol/mol)

35.100 [32.700;37.700]

35.100 [32.700;37.600]

36.050 [33.500;38.800]

<0.001

Diabetes, n (%)

   

<0.001

 None

296,342 (92.732%)

29,0557 (92.933%)

5785 (83.647%)

 

 Yes

23,226 (7.268%)

22,095 (7.067%)

1131 (16.353%)

 
  1. The values of continuous variables (HDL-C, LDL-C, TG, age, BMI, TDI, fasting time, ALT, AST, SBP, and DBP) were presented as medians [upper quartiles; lower quartiles], and the categorial variables (sex, smoking status, alcohol drinking status, education qualification, employment status, medication use, physical activity level, family cancer history, cerebral infarction, ischaemic heart disease, primary hypertension, and diabetes) were displayed as n (%)
  2. BMI Body mass index, TDI Townsend deprivation index, ALT Alanine aminotransferase, AST Aspartate aminotransferase, SBP Systolic blood pressure, DBP Diastolic blood pressure, HbA1c Glycated haemoglobin, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol, TG Triglyceride
  3. aParticipants with DSCs including oesophagus, stomach, colorectal, liver, gallbladder and pancreas cancers were included in this study
  4. bMedication use including cholesterol lowering medication (female and male), blood pressure medication (female and male), insulin (female and male), hormone replacement therapy (female only) or oral contraceptive pill or minipill (female only)
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Lipids in Health and Disease

ISSN: 1476-511X