The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study

Table 2 Prospective associations between the baseline hs-CRP/HDL-C ratio and follow-up incident CVD/stroke/heart problems

	Model 1 ^a	P	Model 2 ^b	P	Model 3 ^c	P
CVD
hs-CRP/HDL-C ratio per IQR	1.019(1.001,1.038)	0.041	1.016(0.997,1.035)	0.090	1.013(0.994,1.033)	0.172
Q1	ref		ref		ref
Q2	1.03 [0.83, 1.30]	0.769	1.02 [0.81, 1.27]	0.897	0.99 [0.79, 1.25]	0.962
Q3	1.35 [1.09, 1.67]	0.007	1.30 [1.05, 1.62]	0.018	1.24 [1.00, 1.55]	0.054
Q4	1.47 [1.19, 1.82]	< 0.001	1.40 [1.13, 1.73]	0.002	1.31 [1.05, 1.64]	0.016
P for trend	< 0.001		< 0.001		0.003
Stroke
hs-CRP/HDL-C ratio per IQR	1.029(1.005,1.053)	0.019	1.023(0.999,1.049)	0.065	1.018(0.992,1.044)	0.175
Q1	ref		ref		ref
Q2	1.13 [0.80, 1.60]	0.481	1.10 [0.78, 1.56]	0.577	1.06 [0.75, 1.50]	0.747
Q3	1.28 [0.92, 1.79]	0.149	1.19 [0.85, 1.68]	0.304	1.09 [0.77, 1.54]	0.638
Q4	1.72 [1.26, 2.37]	0.001	1.57 [1.14, 2.17]	0.006	1.37 [0.99, 1.92]	0.063
P for trend	< 0.001		< 0.001		0.050
Heart problems
hs-CRP/HDL-C ratio per IQR	1.007(0.983,1.032)	0.560	1.006(0.982,1.031)	0.626	1.006(0.982,1.031)	0.628
Q1	ref		ref		ref
Q2	0.98 [0.75, 1.29]	0.892	0.97 [0.73, 1.27]	0.806	0.96 [0.73, 1.27]	0.768
Q3	1.39 [1.08, 1.80]	0.012	1.37 [1.06, 1.78]	0.016	1.35 [1.04, 1.76]	0.026
Q4	1.33 [1.03, 1.72]	0.031	1.29 [1.00, 1.68]	0.053	1.28 [0.98, 1.67]	0.074
P for trend	< 0.001		< 0.001		0.013

hs-CRP, high-density C-reactive protein; CVD, cardiovascular disease; HDL-C, high-density lipoprotein cholesterol; IQR, interquartile range; Q1, the 5th of the hs-CRP/HDL-C ratio; Q2, the 35th of the hs-CRP/HDL-C ratio; Q3, the 65th of the hs-CRP/HDL-C ratio; Q4, the 95th of the hs-CRP/HDL-C ratio
^a Model 1 evaluated the basic connection between the hs-CRP/HDL-C ratio and incident CVD.
^b Model 2 further controlled for sex, education level, residence location, and marital status
^c Model 3 further corrected for health behaviours (smoking status, alcohol intake and sleep duration) and physical and chemical indicators (LDL-C, blood glucose, uric acid, and blood pressure levels)

ISSN: 1476-511X