A mediation analysis of the role of total free fatty acids on pertinence of gut microbiota composition and cognitive function in late life depression

Table 2 Correlations among gut microbes, cognition assessment and lipid profile indexes

Interactions between variables		Correlation coefficient (r)	p value
Gut Microbiota—Cognition Assessment
Akkermansia	MoCA	0.760	< 0.001
	Visuospatial/Executive	0.412	0.026
	Naming	0.373	0.047
	Orientation	0.498	0.006
Prevotella	Attention	0.441	0.017
Parabacteroides	MoCA	0.374	0.046
	Visuospatial/Executive	0.438	0.018
	Orientation	0.517	0.004
Lipid Metabolism- Gut Microbiota
Total FFAs	Akkermansia	-0.543	0.002
Total FFAs	Bifidobacterium	-0.473	0.010
ApoE	Bacteroides	-0.451	0.014
ApoE	Ruminococcus	0.452	0.014
Lipid Metabolism—Cognition Assessment
Total FFAs	MoCA	-0.752	< 0.001
Total FFAs	Visuospatial/Executive	-0.492	0.007

Connections among gut microbes, cognition assessment and lipid profile indexes identified by Spearman correlation
Abbreviations: MoCA Montreal Cognitive Assessment, FFAs Free fatty acids, ApoE Apolipoprotein E
Pvalue < 0.05 was displayed

ISSN: 1476-511X