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Table 4 The mediating effect of total FFAs between Akkermansia and cognition in LLD

From: A mediation analysis of the role of total free fatty acids on pertinence of gut microbiota composition and cognitive function in late life depression

 

Effect value

BootSE

BootLLCI-BootULCI

Relative mediation effect

Total effect

0.604

0.153

0.287–0.920

1

Direct effect (Akkermansia → MoCA)

0.343

0.157

0.190–0.669

0.570

Indirect effect (Akkermansia → total FFAs → MoCA)

0.261

0.135

0.023–0.557

0.430

  1. The relative abundance of Akkermansia was log-transformed as LogAkkermansia
  2. Adjusted for age, sex, education, BMI, Hypertension, diabetes, smoking, drinking
  3. Abbreviations: SE Standard error, LLCI Lower level of confidence interval, ULCI Upper level of confidence interval, MoCA Montreal Cognitive Assessment, FFAs Free fatty acids, LLD Late Life Depression
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Lipids in Health and Disease

ISSN: 1476-511X