Table 1 Characteristics of study participants and a comparison between patients with and without dyslipidemia

DR-TB treatment site

< 0.001

Mulago National Referral Hospital

61 (35.7)

31 (25.8)

30 (58.8)

Lira Regional Referral Hospital

68 (39.8)

55 (45.8)

13 (25.5)

Mbale Regional Referral Hospital

25 (14.6)

23 (19.2)

02 (3.9)

Mbarara Regional Referral Hospital

17 (9.9)

11 (9.2)

06 (11.8)

Age, median (IQR), years

37.0 (31.0, 46.0)

37.0 (30.0, 46.5)

38.5 (32.0, 46.0)

0.519

Males

126 (73.7)

86 (71.7)

40 (78.4)

0.358

Rural residence

104 (60.8)

78 (65.0)

26 (51.0)

0.086

High BMI

14 (8.6)

07 (14.6)

07 (6.1)

0.081

Central Obesity

69 (40.4)

44 (36.7)

25 (49.0)

0.132

Positive HIV status

118 (69.0)

80 (66.7)

38 (74.5)

0.310

Any history of alcohol use

75 (43.1)

55 (45.6)

20 (39.2)

0.425

Any history of smoking

60 (35.1)

41 (34.2)

19 (37.3)

0.699

Duration of current TB treatment, median (IQR), months

6.0 (5.0, 6.0)

6.0 (5.0, 6.0)

6.0 (5.0, 6.0)

0.533

Antiretroviral therapy drugs (among people with HIV), n = 73

Tenofovir

72 (96.0)

53 (98.1)

19 (100.0)

0.550

Lamivudine

72 (96.0)

53 (98.1)

19 (100.0)

0.550

Dolutegravir

61 (83.6)

47 (87.1)

14 (73.7)

0.177

Emitricitabine

1 (1.4)

1 (1.85)

0 (0.0)

0.550

Abacavir

1 (1.4)

1 (1.85)

0 (0.0)

0.550

Atazanavir/Ritonavir

1 (1.4)

1 (1.85)

0 (0.0)

0.550

Efavirenz

11 (15.1)

6 (11.1)

5 (26.3)

0.111

Hemoglobin level, mean (SD), grams per deciliter

14.2 (2.9)

13.8 (2.9)

14.95 (2.7)

0.017

Blood lipids, median (IQR)

Total cholesterol, mmol/l

3.36 (2.7, 4.3)

3.2 (2.6, 5.2)

3.43 (3.1, 4.0)

0.516

High density lipoprotein cholesterol (HDL-c), mmol/l

1.25 (0.9, 1.7)

1.0 (0.8, 1.7)

1.6 (1.3, 1.7)

< 0.001

Triglycerides, mmol/l

1.20 (0.9, 1.6)

1.3(0.9, 02)

1.1 (0.8, 1.4)

0.006

Low density lipoprotein cholesterol (LDL-c), mmol/l

1.67 (1.2, 2.1)

1.7 (1.2, 2.4)

1.6 (1.2, 2.0)

0.245

LDL-c/HDL-c

1.42 (1.0, 1.9)

1.6 (1.2, 2.0)

1.1 (0.7, 1.4)

< 0.001

Biomarkers of inflammation, median (IQR)

Leucocyte count (X10³cells/microliter)

5.71 (4.2, 8.9)

5.1 (4.0, 7.1)

7.7 (4.8, 13.7)

< 0.001

Neutrophil count (X10³cells/microliter)

3.42 (1.9, 7.8)

2.6 (1.7, 6.2)

6.6 (2.4, 11.4)

0.001

Lymphocyte count (X10³cells/microliter)

1.24 (0.3, 1.7)

1.4 (0.5, 1.9)

0.7 (0.1, 1.5)

0.008

Monocyte count (X10³cells/microliter)

0.30 (0.04, 0.6)

0.4 (0.1, 0.6)

0.04 (0.02, 0.2)

< 0.001

Platelet count (X10⁹/litre)

141.5 (81.0, 207.0)

161 (82.5, 219.0)

123.0 (59.0,162.0)

0.014

Mean corpuscular volume (femtolitres)

98.4 (87.8, 106.8)

94.3 (85.3, 104.3)

105.6 (92.4, 115.9)

< 0.001

NLR

13.1 (1.2, 49.9)

2.0 (1.1, 25.2)

15.7 (2.1, 82.2)

0.008

PLR

134.9 (75.8, 270.7)

130.4 (79.0, 208.6)

161.4 (63.0, 1050)

0.506

LMR

3.8 (2.3, 6.5)

3.6 (2.3, 5.0)

5.6 (3.0, 11.5)

0.006

RDW (%)

18.3 (14.9, 22.2)

17.3 (12.0, 21.6)

19.6 (17.9, 23.3)

0.050

SII

334.9 (170.5, 4548.0)

296.9 (161.4, 2033.1)

1960.8 (196.4, 8369.2)

0.049