Fig. 3
From: LDLR c.415G > A causes familial hypercholesterolemia by weakening LDLR binding to LDL
LDLR c.415G > A does not affect LDLR expression. (A) Western blot analysis of LDLR expression in HEK293T cells transfected with wild-type LDLR plasmids, variant LDLR plasmids, and blank plasmids. (B) Quantitative reverse transcription polymerase chain reaction analysis (n = 6/group). (C) Flow cytometry quantification of LDLR expression on the HEK293T cell surface (n = 6/group). Data are presented as means ± SEM. ****P < 0.0001; ns indicates P > 0.05