Fig. 3
From: SGLT2 inhibition, high-density lipoprotein, and kidney function: a mendelian randomization study
The causal effect of SGLT2 inhibition on circulating metabolites and the effect of metabolites on eGFR
(A) The effect of SGLT2 inhibition on the remaining 9 circulating metabolites selected from 249 metabolites, which were significantly associated with SGLT2 inhibition (Bonferroni-corrected P value threshold = 2.00 × 10− 4 [0.05/249])
(B) The effect of the above 9 metabolites on eGFR (Bonferroni-corrected P value threshold = 0.0055 [0.05/9])
SGLT2: sodium-glucose cotransporter 2; eGFR: estimated glomerular filtration rate; HDL: high-density lipoprotein; LDL: low-density lipoprotein; SNP: single-nucleotide polymorphism; CI: confidence interval