Association of birth weight with type 2 diabetes mellitus and the mediating role of fatty acids traits: a two-step mendelian randomization study

Cao, Limin; Wen, Yahui; Fan, Keyi; Wang, Qiwei; Zhang, Yaochen; Li, Zhenglong; Wang, Nan; Zhang, Xinhua

doi:10.1186/s12944-024-02087-z

Lipids in Health and Disease

Table 1 Summary of the GWAS data used in the MR analyses

From: Association of birth weight with type 2 diabetes mellitus and the mediating role of fatty acids traits: a two-step mendelian randomization study

	GWAS ID	Trait	Year	Population	Sample Size	Number of SNPs	Author
Exposure	ukb-b-13,378	Birth weight	2018	European	261,932	9,851,867	Ben Elsworth
Mediator	ebi-a-GCST90092987	TFA	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092980	SFA	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092928	MUFA	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092939	PUFA	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092931	Omega-3 FA	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092933	Omega-6 FA	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092816	DHA	2020	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092880	LA	2021	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90012075	A-FABP	2020	European	21,758	13,138,563	Lasse Folkersen
Mediator	ebi-a-GCST90092981	SFA/TFA ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092929	MUFA/TFA ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092940	PUFA/MUFA ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092941	PUFA/TFA ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092932	Omega-3/TFA ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092934	Omega-6/Omega-3 FA Ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092935	Omega-6/TFA ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092817	DHA/TFA ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	ebi-a-GCST90092881	LA/TFA ratio	2022	European	115,006	11,590,399	Tom G Richardson
Mediator	met-c-845	bisallylic groups/TFA ratio	2016	European	13,171	11,274,684	Johannes Kettunen
Outcome	ebi-a-GCST007516	Type 2 diabetes (adjusted for BMI)	2018	European	298,957	190,208	Anubha Mahajan
Outcome	ebi-a-GCST90002232	Fasting glucose	2021	European	200,622	31,008,728	Ji Chen
Outcome	ebi-a-GCST90002238	Fasting insulin	2021	European	151,013	29,664,438	Ji Chen
Outcome	ieu-b-4842	HbA1c	2022	European	45,734	9,696,819	Howe LJ
Outcome	ebi-a-GCST90002227	Two-hour glucose	2021	European	63,396	27,330,879	Ji Chen

Abbreviations A-FABP, fatty acid-binding protein, adipocyte levels; bisallylic groups/TFA ratio, ratio of bisallylic groups to total fatty acids; DHA, docosahexaenoic acid levels; DHA/TFA ratio, ratio of docosahexaenoic acid to total fatty acid levels; GWAS, genome-wide association study; LA, linoleic acid levels; LA/TFA ratio, ratio of linoleic acid to total fatty acids; MUFA, monounsaturated fatty acid levels; MUFA/TFA ratio, ratio of monounsaturated fatty acids to total fatty acids; Omega-3 FA, omega-3 fatty acid levels; Omega-3/TFA ratio, ratio of omega-3 fatty acids to total fatty acids; Omega-6 FA, omega-6 fatty acid levels; Omega-6/Omega-3 FA ratio, ratio of omega-6 fatty acids to omega-3 fatty acids; Omega-6/TFA ratio, ratio of omega-6 fatty acids to total fatty acids; PUFA, polyunsaturated fatty acid levels; PUFA/MUFA ratio, ratio of polyunsaturated fatty acids to monounsaturated fatty acids; PUFA/TFA ratio, ratio of polyunsaturated fatty acids to total fatty acids; SFA, saturated fatty acid levels; SFA/TFA ratio, ratio of saturated fatty acids to total fatty acids; TFA, total fatty acid levels

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ISSN: 1476-511X

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