Table 2 Proportion of the effect of birth weight on T2DM, fasting glucose, fasting insulin and two-hour glucose mediated by cardiometabolic factors
Exposure | β1(SE) | Mediator | β2(SE) | Outcome | β0(SE) | Mediation proportion |
|---|---|---|---|---|---|---|
Birth weight | 0.107 (0.026) | PUFA/MUFA ratio | −0.819 (0.246) | T2DM | −1.113 (0.235) | 7.9% (1.1%,14.7%) |
0.095 (0.025) | PUFA/TFA ratio | −0.846 (0.254) | 7.2% (0.8%,13.7%) | |||
0.106 (0.028) | Omega-6/TFA ratio | −0.850 (0.255) | 8.1% (0.9%,15.2%) | |||
0.082 (0.025) | LA/TFA ratio | −0.807 (0.261) | 6.0% (0.2%,11.7%) | |||
Birth weight | 0.107 (0.026) | PUFA/MUFA ratio | −0.079 (0.022) | Fasting glucose | −0.061 (0.015) | 13.8% (1.8%,25.9%) |
0.095 (0.025) | PUFA/TFA ratio | −0.083 (0.022) | 12.8% (1.6%,24.1%) | |||
0.106 (0.028) | Omega-6/TFA ratio | −0.081 (0.022) | 13.9% (1.7%,26.2%) | |||
0.082 (0.025) | LA/TFA ratio | −0.078 (0.022) | 10.5% (0.5%,20.5%) | |||
Birth weight | 0.107 (0.026) | PUFA/MUFA ratio | −0.069 (0.021) | Fasting insulin | −0.080 (0.014) | 9.3% (1.4%,17.2%) |
0.095 (0.025) | PUFA/TFA ratio | −0.068 (0.021) | 8.1% (1.0%,15.2%) | |||
0.106 (0.028) | Omega-6/TFA ratio | −0.074 (0.021) | 9.8% (1.7%,17.9%) | |||
0.082 (0.025) | LA/TFA ratio | −0.074 (0.021) | 7.6% (0.8%,14.4%) | |||
Birth weight | 0.107 (0.026) | PUFA/MUFA ratio | −0.304 (0.063) | Two-hour glucose | −0.250 (0.056) | 13.0% (3.0%,23.0%) |
0.095 (0.025) | PUFA/TFA ratio | −0.269 (0.064) | 10.2% (1.8%,18.7%) | |||
0.106 (0.028) | Omega-6/TFA ratio | −0.245 (0.063) | 10.4% (1.6%,19.1%) | |||
0.082 (0.025) | LA/TFA ratio | −0.239 (0.062) | 7.9% (0.7%,15.0%) |