Table 1 Mendelian randomization analysis on the causal effect of blood lipids on endometriosis

Apolipoprotein A-1

Inverse variance weighted

0.898

0.818–0.986

0.025

0.041

0.037

MR Egger

0.879

0.755–1.023

0.097

0.0008

0.725

0.034

Simple mode

0.756

0.568–1.006

0.056

Weighted median

0.948

0.826–1.088

0.447

Weighted mode

0.902

0.787–1.032

0.134

MR-PRESSO

0.893

0.817–0.975

0.013

0.037

Apolipoprotein B

Inverse variance weighted

1.039

0.934–1.154

0.483

0.603

< 0.001

MR Egger

0.952

0.827–1.097

0.501

0.005

0.076

< 0.001

Simple mode

1.083

0.804–1.459

0.601

Weighted median

0.993

0.861–1.146

0.925

Weighted mode

0.956

0.845–1.082

0.479

MR-PRESSO

1.004

0.915–1.103

0.929

< 0.001

HDL

cholesterol

Inverse variance weighted

0.892

0.812–0.979

0.016

0.040

< 0.001

MR Egger

0.948

0.822–1.092

0.458

-0.002

0.266

< 0.001

Simple mode

0.872

0.652–1.165

0.354

Weighted median

0.887

0.777–1.013

0.077

Weighted mode

0.893

0.785–1.016

0.087

MR-PRESSO

0.899

0.824–0.981

0.018

< 0.001

LDL

cholesterol

Inverse variance weighted

1.019

0.904–1.150

0.755

0.755

< 0.001

MR Egger

0.916

0.769–1.092

0.329

0.005

0.105

< 0.001

Simple mode

0.948

0.689–1.304

0.741

Weighted median

0.942

0.807-1.100

0.454

Weighted mode

0.899

0.785–1.029

0.125

MR-PRESSO

0.969

0.873–1.075

0.550

< 0.001

Triglycerides

Inverse variance weighted

1.150

1.043–1.267

0.005

0.025

< 0.001

MR Egger

1.158

1.002–1.337

0.048

-0.0003

0.900

< 0.001

Simple mode

1.354

0.983–1.866

0.065

Weighted median

1.062

0.926–1.218

0.388

Weighted mode

1.130

0.990–1.291

0.072

MR-PRESSO

1.159

1.054–1.275

0.002

< 0.001