Figure 5

A tracing illustrating the reduced acetylcholine-induced vasorelaxation of a common carotid artery ring that was precontracted using the thromboxane analog U46619 in a male apolipoprotein E-deficient (ApoE) mouse compared with a wild-type C57BL/6J (control) mouse. Both animals were fed a lipid-rich Western-type diet for 26 weeks. Reproduced with permission from d'Uscio et al. [80].