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Figure 6 | Lipids in Health and Disease

Figure 6

From: Endothelial Dysfunction in the Apolipoprotein E-deficient Mouse: insights into the influence of diet, gender and aging

Figure 6

Hypothetical scheme illustrating the possible mechanisms that lead to endothelial nitric oxide synthase (eNOS) uncoupling (thick lines/arrows), which results in a reduction of nitric oxide (NO) release and an exacerbation of superoxide anion (•O 2 -) production, generating peroxynitrite (•ONOO-) and thus, leading to impaired vasodilation. The main causes of the generation of excessive •O2- and the resultant endothelial dysfunction are highlighted. Abbreviations (some are listed in Figure 3): ADMA, asymmetric dimethyl-L-arginine; Ang II, angiotensin II; AT1R, Ang II type 1 receptor; CRP, C-reactive protein; Lox, lipoxygenases; oxLDL, oxidized low-density lipoprotein.

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Lipids in Health and Disease

ISSN: 1476-511X