dhastagir sheriff, Faculty of Medicine,Garyounis university, Benghazi
21 August 2010
It is very interesting to note that lactic acid producing bacteria reduce plasma cholesterol and possibly influence membrane cholesterol in cancer patients.One need to understand that there is always a thin line that divides beneficial as well as harmful effects. One must remember that lactic acidosis is an end stage complication of patients with metastases in the liver(1). Altering membrane cholesterol may affect membrane signaling pathways so vital for maintaining cell growth and regulation. (2). Therefore, one must be cautious in extrapolating experimental results to say human cancer biology and therapy. References: 1. D. S. Sheriff Lactic acidosis and small cell carcinoma of the lung. Postgrad Med J 1986;62:297-298 2. Xu Chen and Marilyn D. Resh. Cholesterol Depletion from the Plasma Membrane Triggers Ligandi ndependent Activation of the Epidermal Growth Factor Receptor* Journal of Biological Chemistry,2002; 277: 49631-49637
Competing interests
no competing interesting or whatsover to influence my observation. dhastagir sheriff
Lipids in Health and Disease
Membrane cholesterol, lactic acid and cancer
21 August 2010
It is very interesting to note that lactic acid producing bacteria reduce plasma cholesterol and possibly influence membrane cholesterol in cancer patients.One need to understand that there is always a thin line that divides beneficial as well as harmful effects. One must remember that lactic acidosis is an end stage complication of patients with metastases in the liver(1). Altering membrane cholesterol may affect membrane signaling pathways so vital for maintaining cell growth and regulation. (2). Therefore, one must be cautious in extrapolating experimental results to say human cancer biology and therapy.
References:
1. D. S. Sheriff Lactic acidosis and small cell carcinoma of the lung. Postgrad Med J 1986;62:297-298
2. Xu Chen and Marilyn D. Resh. Cholesterol Depletion from the Plasma Membrane Triggers Ligandi ndependent Activation of the Epidermal Growth Factor Receptor* Journal of Biological Chemistry,2002; 277: 49631-49637
Competing interests
no competing interesting or whatsover to influence my observation. dhastagir sheriff