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Table 4 Proposed differences between the wild type and Fat-1 mouse.

From: Transgenic fat-1 mouse as a model to study the pathophysiology of cardiovascular, neurological and psychiatric disorders

Parameter Wild type Fat-1 mouse
Cell membrane Fluidity More fluid
Endothelial NO
IL-6, TNF-α, IL-1, IL-2,
MIF, HMGB1
IL-4, IL-10
HMG-CoA reductase activity
Plasma and tissue levels of EPA/DHA
Plasma and tissue levels of lipoxins, resolvins,
protectins and maresins
PGE1/PGI2/PGI3
Ras activity
BMPs
UCP-1
Expression of Adhesion Molecules
PPARs
Inflammatory diseases* common Uncommon/less severe
Blood pressure Normal
Type 1 and Type 2 diabetes common Uncommon/less severe
CHD common Uncommon/less severe
  1. CHD = Coronary heart disease
  2. Inflammatory diseases*include: rheumatological conditions such as rheumatoid arthritis, lupus, scleroderma, ankylosing spondylitis, vasculitis, interstitial lung disease, etc; neurological conditions such as stroke, Huntington's disease, Alzheimer's disease, depression, schizophrenia, familial and non-familial neurodegenerative conditions, amyotrophic lateral sclerosis, bulbar palsy, pseudobulbar palsy, inflammatory diseases of the bowel such as ulcerative colitis, Crohn's disease, Celiac disease, etc., psoriasis, glomerulonephritis, atherosclerosis, Parkinson's disease, hepatitis both specific and non-specific types, non-alcoholic fatty liver disease, insulin resistance, diabetes mellitus, metabolic syndrome, osteoporosis and all other conditions in which inflammation plays a role.
  3. ↔ Indicates normal frequency or incidence of the disease.
  4. In the Fat-1 mouse, all the diseases enumerated above either will be less common or when they are induced or occur will run a much milder course compared to the severity of the disease seen in the wild type mouse.