Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q: Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta. 2006, 1758: 1864-1884. 10.1016/j.bbamem.2006.08.009
Article
CAS
PubMed
Google Scholar
Hannun YA, Obeid LM: The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem. 2002, 277: 25847-25850. 10.1074/jbc.R200008200
Article
CAS
PubMed
Google Scholar
Kolesnick R, Golde DW: The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell. 1994, 77: 325-328. 10.1016/0092-8674(94)90147-3
Article
CAS
PubMed
Google Scholar
Hannun YA: The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem. 1994, 269: 3125-3128.
CAS
PubMed
Google Scholar
Hannun YA, Obeid LM: Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 1995, 20: 73-77. 10.1016/S0968-0004(00)88961-6
Article
CAS
PubMed
Google Scholar
Dressler KA, Mathias S, Kolesnick RN: Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system. Science. 1992, 255: 1715-1718. 10.1126/science.1313189
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A: Modulation of cell signalling by ceramides. Biochim Biophys Acta. 1998, 1391: 92-109.
Article
CAS
PubMed
Google Scholar
Mathias S, Dressler KA, Kolesnick RN: Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. Proc Natl Acad Sci USA. 1991, 88: 10009-10013. 10.1073/pnas.88.22.10009
Article
PubMed Central
CAS
PubMed
Google Scholar
Mathias S, Kolesnick R: Ceramide: a novel second messenger. Adv Lipid Res. 1993, 25: 65-90.
CAS
PubMed
Google Scholar
Okazaki T, Bielawska A, Bell RM, Hannun YA: Role of ceramide as a lipid mediator of 1 alpha, 25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1990, 265: 15823-15831.
CAS
PubMed
Google Scholar
Menaldino DS, Bushnev A, Sun A, Liotta DC, Symolon H, Desai K, Dillehay DL, Peng Q, Wang E, Allegood J: Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action. Pharmacol Res. 2003, 47: 373-381. 10.1016/S1043-6618(03)00054-9
Article
CAS
PubMed
Google Scholar
Adams JM, Pratipanawatr T, Berria R, Wang E, DeFronzo RA, Sullards MC, Mandarino LJ: Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes. 2004, 53: 25-31. 10.2337/diabetes.53.1.25
Article
CAS
PubMed
Google Scholar
Schmitz-Peiffer C: Protein kinase C and lipid-induced insulin resistance in skeletal muscle. Ann NY Acad Sci. 2002, 967: 146-157.
Article
CAS
PubMed
Google Scholar
Stratford S, Hoehn KL, Liu F, Summers SA: Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem. 2004, 279: 36608-36615. 10.1074/jbc.M406499200
Article
CAS
PubMed
Google Scholar
Merrill AH: De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem. 2002, 277: 25843-25846. 10.1074/jbc.R200009200
Article
CAS
PubMed
Google Scholar
Merrill AH, Sullards MC, Allegood JC, Kelly S, Wang E: Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods. 2005, 36: 207-224. 10.1016/j.ymeth.2005.01.009
Article
CAS
PubMed
Google Scholar
Pettus BJ, Bielawska A, Kroesen BJ, Moeller PD, Szulc ZM, Hannun YA, Busman M: Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003, 17: 1203-1211. 10.1002/rcm.1043
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A: Ceramide-1-phosphate: a novel regulator of cell activation. FEBS Lett. 2004, 562: 5-10.
Article
CAS
PubMed
Google Scholar
Chalfant CE, Spiegel S: Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci. 2005, 118: 4605-4612. 10.1242/jcs.02637
Article
CAS
PubMed
Google Scholar
Lamour NF, Chalfant CE: Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation. Mol Interv. 2005, 5: 358-367. 10.1124/mi.5.6.8
Article
CAS
PubMed
Google Scholar
Hinkovska-Galcheva V, Boxer LA, Kindzelskii A, Hiraoka M, Abe A, Goparju S, Spiegel S, Petty HR, Shayman JA: Ceramide 1-phosphate, a mediator of phagocytosis. J Biol Chem. 2005, 280: 26612-26621. 10.1074/jbc.M501359200
Article
CAS
PubMed
Google Scholar
Hinkovska-Galcheva VT, Boxer LA, Mansfield PJ, Harsh D, Blackwood A, Shayman JA: The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion. J Biol Chem. 1998, 273: 33203-33209. 10.1074/jbc.273.50.33203
Article
CAS
PubMed
Google Scholar
Pewzner-Jung Y, Ben-Dor S, Futerman AH: When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. J Biol Chem. 2006, 281: 25001-25005. 10.1074/jbc.R600010200
Article
CAS
PubMed
Google Scholar
Hannun YA, Obeid LM: Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008, 9: 139-150. 10.1038/nrm2329
Article
CAS
PubMed
Google Scholar
Desai K, Sullards MC, Allegood J, Wang E, Schmelz EM, Hartl M, Humpf HU, Liotta DC, Peng Q, Merrill AH: Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis. Biochim Biophys Acta. 2002, 1585: 188-192.
Article
CAS
PubMed
Google Scholar
Kolesnick RN, Goni FM, Alonso A: Compartmentalization of ceramide signaling: physical foundations and biological effects. J Cell Physiol. 2000, 184: 285-300. 10.1002/1097-4652(200009)184:3<285::AID-JCP2>3.0.CO;2-3
Article
CAS
PubMed
Google Scholar
Goni FM, Alonso A: Sphingomyelinases: enzymology and membrane activity. FEBS Lett. 2002, 531: 38-46. 10.1016/S0014-5793(02)03482-8
Article
CAS
PubMed
Google Scholar
Cremesti AE, Goni FM, Kolesnick R: Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?. FEBS Lett. 2002, 531: 47-53. 10.1016/S0014-5793(02)03489-0
Article
CAS
PubMed
Google Scholar
Gouaze-Andersson V, Cabot MC: Glycosphingolipids and drug resistance. Biochim Biophys Acta. 2006, 1758: 2096-2103. 10.1016/j.bbamem.2006.08.012
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A: Ceramide 1-phosphate/ceramide, a switch between life and death. Biochim Biophys Acta. 2006, 1758: 2049-2056. 10.1016/j.bbamem.2006.05.011
Article
CAS
PubMed
Google Scholar
Pettus BJ, Chalfant CE, Hannun YA: Sphingolipids in inflammation: roles and implications. Curr Mol Med. 2004, 4: 405-418. 10.2174/1566524043360573
Article
CAS
PubMed
Google Scholar
Hertervig E, Nilsson A, Cheng Y, Duan RD: Purified intestinal alkaline sphingomyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells. J Cancer Res Clin Oncol. 2003, 129: 577-582. 10.1007/s00432-003-0466-2
Article
CAS
PubMed
Google Scholar
Duan RD, Nilsson A: Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development. Prog Lipid Res. 2009, 48: 62-72. 10.1016/j.plipres.2008.04.003
Article
CAS
PubMed
Google Scholar
Gangoiti P, Granado MH, Arana L, Ouro A, Gomez-Munoz A: Activation of protein kinase C-alpha is essential for stimulation of cell proliferation by ceramide 1-phosphate. FEBS Lett. 2010, 584 (3): 517-24. Epub 2009 Nov 27, 10.1016/j.febslet.2009.11.086
Article
CAS
PubMed
Google Scholar
Hannun YA, Loomis CR, Merrill AH, Bell RM: Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem. 1986, 261: 12604-12609.
CAS
PubMed
Google Scholar
Smith ER, Jones PL, Boss JM, Merrill AH: Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases. J Biol Chem. 1997, 272: 5640-5646. 10.1074/jbc.272.9.5640
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A, Hamza EH, Brindley DN: Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes. Biochim Biophys Acta. 1992, 1127: 49-56.
Article
CAS
PubMed
Google Scholar
Jamal Z, Martin A, Gomez-Munoz A, Brindley DN: Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol. J Biol Chem. 1991, 266: 2988-2996.
CAS
PubMed
Google Scholar
Natarajan V, Jayaram HN, Scribner WM, Garcia JG: Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. Am J Respir Cell Mol Biol. 1994, 11: 221-229.
Article
CAS
PubMed
Google Scholar
Sakane F, Yamada K, Kanoh H: Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol. FEBS Lett. 1989, 255: 409-413. 10.1016/0014-5793(89)81134-2
Article
CAS
PubMed
Google Scholar
Yamada K, Sakane F, Imai S, Takemura H: Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line. Biochim Biophys Acta. 1993, 1169: 217-224.
Article
CAS
PubMed
Google Scholar
Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S: Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem. 2000, 275: 19513-19520. 10.1074/jbc.M002759200
Article
CAS
PubMed
Google Scholar
Urs AN, Dammer E, Sewer MB: Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. Endocrinology. 2006, 147: 5249-5258. 10.1210/en.2006-0355
Article
CAS
PubMed
Google Scholar
Spiegel S, English D, Milstien S: Sphingosine 1-phosphate signaling: providing cells with a sense of direction. Trends Cell Biol. 2002, 12: 236-242. 10.1016/S0962-8924(02)02277-8
Article
CAS
PubMed
Google Scholar
Spiegel S, Milstien S: Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol. 2003, 4: 397-407. 10.1038/nrm1103
Article
CAS
PubMed
Google Scholar
Spiegel S, Milstien S: Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem. 2002, 277: 25851-25854. 10.1074/jbc.R200007200
Article
CAS
PubMed
Google Scholar
Rabano M, Pena A, Brizuela L, Marino A, Macarulla JM, Trueba M, Gomez-Munoz A: Sphingosine-1-phosphate stimulates cortisol secretion. FEBS Lett. 2003, 535: 101-105. 10.1016/S0014-5793(02)03882-6
Article
CAS
PubMed
Google Scholar
Brizuela L, Rabano M, Pena A, Gangoiti P, Macarulla JM, Trueba M, Gomez-Munoz A: Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion. J Lipid Res. 2006, 47: 1238-1249. 10.1194/jlr.M500510-JLR200
Article
CAS
PubMed
Google Scholar
Taha TA, Hannun YA, Obeid LM: Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006, 39: 113-131.
Article
CAS
PubMed
Google Scholar
Merrill AH: Cell regulation by sphingosine and more complex sphingolipids. J Bioenerg Biomembr. 1991, 23: 83-104.
CAS
PubMed
Google Scholar
Merrill AH, Jones DD: An update of the enzymology and regulation of sphingomyelin metabolism. Biochim Biophys Acta. 1990, 1044: 1-12.
Article
CAS
PubMed
Google Scholar
Merrill AH, Schmelz EM, Dillehay DL, Spiegel S, Shayman JA, Schroeder JJ, Riley RT, Voss KA, Wang E: Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol Appl Pharmacol. 1997, 142: 208-225. 10.1006/taap.1996.8029
Article
CAS
PubMed
Google Scholar
Kolesnick R: The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest. 2002, 110: 3-8.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kolesnick RN: 1, 2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. J Biol Chem. 1987, 262: 16759-16762.
CAS
PubMed
Google Scholar
Kolesnick RN, Hemer MR: Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity. J Biol Chem. 1990, 265: 18803-18808.
CAS
PubMed
Google Scholar
Hannun YA: Functions of ceramide in coordinating cellular responses to stress. Science. 1996, 274: 1855-1859. 10.1126/science.274.5294.1855
Article
CAS
PubMed
Google Scholar
Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M: Molecular machinery for non-vesicular trafficking of ceramide. Nature. 2003, 426: 803-809. 10.1038/nature02188
Article
CAS
PubMed
Google Scholar
Huwiler A, Fabbro D, Pfeilschifter J: Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells. Biochemistry. 1998, 37: 14556-14562. 10.1021/bi981401i
Article
CAS
PubMed
Google Scholar
Ibitayo AI, Sladick J, Tuteja S, Louis-Jacques O, Yamada H, Groblewski G, Welsh M, Bitar KN: HSP27 in signal transduction and association with contractile proteins in smooth muscle cells. Am J Physiol. 1999, 277: G445-454.
CAS
PubMed
Google Scholar
Sawai H, Okazaki T, Takeda Y, Tashima M, Sawada H, Okuma M, Kishi S, Umehara H, Domae N: Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis. J Biol Chem. 1997, 272: 2452-2458. 10.1074/jbc.272.4.2452
Article
CAS
PubMed
Google Scholar
Sumitomo M, Ohba M, Asakuma J, Asano T, Kuroki T, Asano T, Hayakawa M: Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. J Clin Invest. 2002, 109: 827-836.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U, Saito N: Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex. J Biol Chem. 2004, 279: 12668-12676. 10.1074/jbc.M312350200
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A, Martin A, O'Brien L, Brindley DN: Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. J Biol Chem. 1994, 269: 8937-8943.
CAS
PubMed
Google Scholar
Gomez-Munoz A, Waggoner DW, O'Brien L, Brindley DN: Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. J Biol Chem. 1995, 270: 26318-26325. 10.1074/jbc.270.44.26318
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A, Martens JS, Steinbrecher UP: Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages. Arterioscler Thromb Vasc Biol. 2000, 20: 135-143.
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A, O'Brien L, Hundal R, Steinbrecher UP: Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages. J Lipid Res. 1999, 40: 988-993.
CAS
PubMed
Google Scholar
Gomez-Munoz A, O'Brien L, Steinbrecher UP: The platelet-activating factor receptor antagonist L-659, 989 inhibits phospholipase D activity. Biochim Biophys Acta. 1999, 1438: 247-252.
Article
CAS
PubMed
Google Scholar
Rabano M, Pena A, Brizuela L, Macarulla JM, Gomez-Munoz A, Trueba M: Angiotensin II-stimulated cortisol secretion is mediated by phospholipase D. Mol Cell Endocrinol. 2004, 222: 9-20. 10.1016/j.mce.2004.05.006
Article
CAS
PubMed
Google Scholar
Venable ME, Obeid LM: Phospholipase D in cellular senescence. Biochim Biophys Acta. 1999, 1439: 291-298.
Article
CAS
PubMed
Google Scholar
Perez-Andres E, Fernandez-Rodriguez M, Gonzalez M, Zubiaga A, Vallejo A, Garcia I, Matute C, Pochet S, Dehaye JP, Trueba M: Activation of phospholipase D-2 by P2X(7) agonists in rat submandibular gland acini. J Lipid Res. 2002, 43: 1244-1255.
CAS
PubMed
Google Scholar
Abousalham A, Liossis C, O'Brien L, Brindley DN: Cell-permeable ceramides prevent the activation of phospholipase D by ADP-ribosylation factor and RhoA. J Biol Chem. 1997, 272: 1069-1075. 10.1074/jbc.272.2.1069
Article
CAS
PubMed
Google Scholar
Venable ME, Bielawska A, Obeid LM: Ceramide inhibits phospholipase D in a cell-free system. J Biol Chem. 1996, 271: 24800-24805. 10.1074/jbc.271.40.24800
Article
CAS
PubMed
Google Scholar
Steinbrecher UP, Gomez-Munoz A, Duronio V: Acid sphingomyelinase in macrophage apoptosis. Curr Opin Lipidol. 2004, 15: 531-537. 10.1097/00041433-200410000-00006
Article
CAS
PubMed
Google Scholar
Kockx MM, De Meyer GR, Buyssens N, Knaapen MW, Bult H, Herman AG: Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal. Circ Res. 1998, 83: 378-387.
Article
CAS
PubMed
Google Scholar
Mao C, Obeid LM: Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta. 2008, 1781: 424-434.
Article
PubMed Central
CAS
PubMed
Google Scholar
Auge N, Nikolova-Karakashian M, Carpentier S, Parthasarathy S, Negre-Salvayre A, Salvayre R, Merrill AH, Levade T: Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J Biol Chem. 1999, 274: 21533-21538. 10.1074/jbc.274.31.21533
Article
CAS
PubMed
Google Scholar
Geoffroy K, Troncy L, Wiernsperger N, Lagarde M, El Bawab S: Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels. FEBS Lett. 2005, 579: 1249-1254. 10.1016/j.febslet.2004.12.094
Article
CAS
PubMed
Google Scholar
Geoffroy K, Wiernsperger N, Lagarde M, El Bawab S: Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids. J Biol Chem. 2004, 279: 34343-34352. 10.1074/jbc.M403273200
Article
CAS
PubMed
Google Scholar
Zager RA, Conrad DS, Burkhart K: Ceramide accumulation during oxidant renal tubular injury: mechanisms and potential consequences. J Am Soc Nephrol. 1998, 9: 1670-1680.
CAS
PubMed
Google Scholar
Partovian C, Ju R, Zhuang ZW, Martin KA, Simons M: Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Mol Cell. 2008, 32: 140-149. 10.1016/j.molcel.2008.09.010
Article
PubMed Central
CAS
PubMed
Google Scholar
Straczkowski M, Kowalska I, Baranowski M, Nikolajuk A, Otziomek E, Zabielski P, Adamska A, Blachnio A, Gorski J, Gorska M: Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes. Diabetologia. 2007, 50: 2366-2373. 10.1007/s00125-007-0781-2
Article
CAS
PubMed
Google Scholar
Samad F, Hester KD, Yang G, Hannun YA, Bielawski J: Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes. 2006, 55: 2579-2587. 10.2337/db06-0330
Article
CAS
PubMed
Google Scholar
Blachnio-Zabielska A, Zabielski P, Baranowski M, Gorski J: Effects of Streptozotocin-induced Diabetes and Elevation of Plasma FFA on Ceramide Metabolism in Rat Skeletal Muscle. Horm Metab Res. 2010, 42: 1-7. 10.1055/s-0029-1238322
Article
CAS
PubMed
Google Scholar
Chavez JA, Holland WL, Bar J, Sandhoff K, Summers SA: Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem. 2005, 280: 20148-20153. 10.1074/jbc.M412769200
Article
CAS
PubMed
Google Scholar
Franzen R, Fabbro D, Aschrafi A, Pfeilschifter J, Huwiler A: Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C. J Biol Chem. 2002, 277: 46184-46190. 10.1074/jbc.M204034200
Article
CAS
PubMed
Google Scholar
Franzen R, Pfeilschifter J, Huwiler A: Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures. FEBS Lett. 2002, 532: 441-444. 10.1016/S0014-5793(02)03727-4
Article
CAS
PubMed
Google Scholar
Pahan K, Sheikh FG, Khan M, Namboodiri AM, Singh I: Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem. 1998, 273: 2591-2600. 10.1074/jbc.273.5.2591
Article
CAS
PubMed
Google Scholar
Amadou A, Nawrocki A, Best-Belpomme M, Pavoine C, Pecker F: Arachidonic acid mediates dual effect of TNF-alpha on Ca2+ transients and contraction of adult rat cardiomyocytes. Am J Physiol Cell Physiol. 2002, 282: C1339-1347.
Article
CAS
PubMed
Google Scholar
Hatano Y, Terashi H, Arakawa S, Katagiri K: Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factor-alpha and interferon-gamma in human epidermis. J Invest Dermatol. 2005, 124: 786-792. 10.1111/j.0022-202X.2005.23651.x
Article
CAS
PubMed
Google Scholar
Radin MJ, Holycross BJ, Dumitrescu C, Kelley R, Altschuld RA: Leptin modulates the negative inotropic effect of interleukin-1beta in cardiac myocytes. Mol Cell Biochem. 2008, 315: 179-184. 10.1007/s11010-008-9805-6
Article
CAS
PubMed
Google Scholar
Oral H, Dorn GW, Mann DL: Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte. J Biol Chem. 1997, 272: 4836-4842. 10.1074/jbc.272.8.4836
Article
CAS
PubMed
Google Scholar
Lin CI, Chen CN, Chen JH, Lee H: Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism. J Cell Biochem. 2006, 99: 1216-1232. 10.1002/jcb.20963
Article
CAS
PubMed
Google Scholar
Kaszkin M, Huwiler A, Scholz K, Bosch van den H, Pfeilschifter J: Negative regulation of interleukin-1beta-activated neutral sphingomyelinase by protein kinase C in rat mesangial cells. FEBS Lett. 1998, 440: 163-166. 10.1016/S0014-5793(98)01445-8
Article
CAS
PubMed
Google Scholar
Franzen R, Pautz A, Brautigam L, Geisslinger G, Pfeilschifter J, Huwiler A: Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells. J Biol Chem. 2001, 276: 35382-35389. 10.1074/jbc.M102153200
Article
CAS
PubMed
Google Scholar
Zeidan YH, Jenkins RW, Korman JB, Liu X, Obeid LM, Norris JS, Hannun YA: Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets. 2008, 9: 653-661. 10.2174/138945008785132358
Article
PubMed Central
CAS
PubMed
Google Scholar
Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA: Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005, 280: 27879-27887. 10.1074/jbc.M503002200
Article
CAS
PubMed
Google Scholar
Strelow A, Bernardo K, Adam-Klages S, Linke T, Sandhoff K, Kronke M, Adam D: Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. J Exp Med. 2000, 192: 601-612. 10.1084/jem.192.5.601
Article
PubMed Central
CAS
PubMed
Google Scholar
De Vito WJ, Xhaja K, Stone S: Prenatal alcohol exposure increases TNFalpha-induced cytotoxicity in primary astrocytes. Alcohol. 2000, 21: 63-71. 10.1016/S0741-8329(00)00078-1
Article
CAS
PubMed
Google Scholar
Nikolova-Karakashian M, Morgan ET, Alexander C, Liotta DC, Merrill AH: Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11. J Biol Chem. 1997, 272: 18718-18724. 10.1074/jbc.272.30.18718
Article
CAS
PubMed
Google Scholar
Coroneos E, Martinez M, McKenna S, Kester M: Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation. J Biol Chem. 1995, 270: 23305-23309. 10.1074/jbc.270.40.23305
Article
CAS
PubMed
Google Scholar
Payne SG, Brindley DN, Guilbert LJ: Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts. J Cell Physiol. 1999, 180: 263-270. 10.1002/(SICI)1097-4652(199908)180:2<263::AID-JCP14>3.0.CO;2-H
Article
CAS
PubMed
Google Scholar
Eliyahu E, Park JH, Shtraizent N, He X, Schuchman EH: Acid ceramidase is a novel factor required for early embryo survival. FASEB J. 2007, 21: 1403-1409. 10.1096/fj.06-7016com
Article
CAS
PubMed
Google Scholar
Okino N, Ito M: Ceramidase enhances phospholipase C-induced hemolysis by Pseudomonas aeruginosa. J Biol Chem. 2007, 282: 6021-6030. 10.1074/jbc.M603088200
Article
CAS
PubMed
Google Scholar
Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW: Acid ceramidase inhibition: a novel target for cancer therapy. Front Biosci. 2008, 13: 2293-2298. 10.2741/2843
Article
CAS
PubMed
Google Scholar
Park JH, Schuchman EH: Acid ceramidase and human disease. Biochim Biophys Acta. 2006, 1758: 2133-2138. 10.1016/j.bbamem.2006.08.019
Article
CAS
PubMed
Google Scholar
Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY, Meacham WD, Mahdy AE, Saad AF, Turner LS: Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther. 2007, 15: 1259-1263. 10.1038/sj.mt.6300167
Article
CAS
PubMed
Google Scholar
Seelan RS, Qian C, Yokomizo A, Bostwick DG, Smith DI, Liu W: Human acid ceramidase is overexpressed but not mutated in prostate cancer. Genes Chromosomes Cancer. 2000, 29: 137-146. 10.1002/1098-2264(2000)9999:9999<::AID-GCC1018>3.0.CO;2-E
Article
CAS
PubMed
Google Scholar
Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA: Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem. 2000, 275: 9078-9084. 10.1074/jbc.275.12.9078
Article
CAS
PubMed
Google Scholar
Ruckhaberle E, Rody A, Engels K, Gaetje R, von Minckwitz G, Schiffmann S, Grosch S, Geisslinger G, Holtrich U, Karn T, Kaufmann M: Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res Treat. 2008, 112: 41-52. 10.1007/s10549-007-9836-9
Article
PubMed
CAS
Google Scholar
Ruckhaberle E, Holtrich U, Engels K, Hanker L, Gatje R, Metzler D, Karn T, Kaufmann M, Rody A: Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer. Climacteric. 2009, 1-12.
Google Scholar
Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE, Turner LS, Cheng J, Bielawska A, Bielawski J: The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther. 2007, 6: 1455-1460.
Article
CAS
PubMed
Google Scholar
Bajjalieh SM, Martin TF, Floor E: Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles. J Biol Chem. 1989, 264: 14354-14360.
CAS
PubMed
Google Scholar
Mitsutake S, Kim TJ, Inagaki Y, Kato M, Yamashita T, Igarashi Y: Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells. J Biol Chem. 2004, 279: 17570-17577. 10.1074/jbc.M312885200
Article
CAS
PubMed
Google Scholar
Boath A, Graf C, Lidome E, Ullrich T, Nussbaumer P, Bornancin F: Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin. J Biol Chem. 2008, 283: 8517-8526. 10.1074/jbc.M707107200
Article
CAS
PubMed
Google Scholar
Lamour NF, Stahelin RV, Wijesinghe DS, Maceyka M, Wang E, Allegood JC, Merrill AH, Cho W, Chalfant CE: Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. J Lipid Res. 2007, 48: 1293-1304. 10.1194/jlr.M700083-JLR200
Article
CAS
PubMed
Google Scholar
Baumruker T, Bornancin F, Billich A: The role of sphingosine and ceramide kinases in inflammatory responses. Immunol Lett. 2005, 96: 175-185. 10.1016/j.imlet.2004.09.001
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A, Kong JY, Salh B, Steinbrecher UP: Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res. 2004, 45: 99-105. 10.1194/jlr.M300158-JLR200
Article
CAS
PubMed
Google Scholar
Sugiura M, Kono K, Liu H, Shimizugawa T, Minekura H, Spiegel S, Kohama T: Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem. 2002, 277: 23294-23300. 10.1074/jbc.M201535200
Article
CAS
PubMed
Google Scholar
Kim TJ, Mitsutake S, Kato M, Igarashi Y: The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity. FEBS Lett. 2005, 579: 4383-4388. 10.1016/j.febslet.2005.06.079
Article
CAS
PubMed
Google Scholar
Kim TJ, Mitsutake S, Igarashi Y: The interaction between the pleckstrin homology domain of ceramide kinase and phosphatidylinositol 4, 5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels. Biochem Biophys Res Commun. 2006, 342: 611-617. 10.1016/j.bbrc.2006.01.170
Article
CAS
PubMed
Google Scholar
Lidome E, Graf C, Jaritz M, Schanzer A, Rovina P, Nikolay R, Bornancin F: A conserved cysteine motif essential for ceramide kinase function. Biochimie. 2008, 90: 1560-1565. 10.1016/j.biochi.2008.07.001
Article
CAS
PubMed
Google Scholar
Rovina P, Schanzer A, Graf C, Mechtcheriakova D, Jaritz M, Bornancin F: Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains. Biochim Biophys Acta. 2009, 1791: 1023-1030.
Article
CAS
PubMed
Google Scholar
Wijesinghe DS, Massiello A, Subramanian P, Szulc Z, Bielawska A, Chalfant CE: Substrate specificity of human ceramide kinase. J Lipid Res. 2005, 46: 2706-2716. 10.1194/jlr.M500313-JLR200
Article
CAS
PubMed
Google Scholar
Van Overloop H, Denizot Y, Baes M, Van Veldhoven PP: On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. Biol Chem. 2007, 388: 315-324. 10.1515/BC.2007.035
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A, Duffy PA, Martin A, O'Brien L, Byun HS, Bittman R, Brindley DN: Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol Pharmacol. 1995, 47: 833-839.
CAS
PubMed
Google Scholar
Pettus BJ, Bielawska A, Spiegel S, Roddy P, Hannun YA, Chalfant CE: Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003, 278: 38206-38213. 10.1074/jbc.M304816200
Article
CAS
PubMed
Google Scholar
Tuson M, Marfany G, Gonzalez-Duarte R: Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26). Am J Hum Genet. 2004, 74: 128-138. 10.1086/381055
Article
PubMed Central
CAS
PubMed
Google Scholar
Graf C, Zemann B, Rovina P, Urtz N, Schanzer A, Reuschel R, Mechtcheriakova D, Muller M, Fischer E, Reichel C: Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice. J Immunol. 2008, 180: 3457-3466.
Article
CAS
PubMed
Google Scholar
Bornancin F, Mechtcheriakova D, Stora S, Graf C, Wlachos A, Devay P, Urtz N, Baumruker T, Billich A: Characterization of a ceramide kinase-like protein. Biochim Biophys Acta. 2005, 1687: 31-43.
Article
CAS
PubMed
Google Scholar
Gangoiti P, Granado MH, Wang SW, Kong JY, Steinbrecher UP, Gomez-Munoz A: Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways. Cell Signal. 2008, 20: 726-736. 10.1016/j.cellsig.2007.12.008
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A, Frago LM, Alvarez L, Varela-Nieto I: Stimulation of DNA synthesis by natural ceramide 1-phosphate. Biochem J. 1997, 325 (Pt 2): 435-440.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gomez-Munoz A, Kong JY, Parhar K, Wang SW, Gangoiti P, Gonzalez M, Eivemark S, Salh B, Duronio V, Steinbrecher UP: Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway. FEBS Lett. 2005, 579: 3744-3750. 10.1016/j.febslet.2005.05.067
Article
CAS
PubMed
Google Scholar
Mitra P, Maceyka M, Payne SG, Lamour N, Milstien S, Chalfant CE, Spiegel S: Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells. FEBS Lett. 2007, 581: 735-740. 10.1016/j.febslet.2007.01.041
Article
CAS
PubMed
Google Scholar
Graf C, Rovina P, Tauzin L, Schanzer A, Bornancin F: Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells. Biochem Biophys Res Commun. 2007, 354: 309-314. 10.1016/j.bbrc.2006.12.208
Article
CAS
PubMed
Google Scholar
Hundal RS, Gomez-Munoz A, Kong JY, Salh BS, Marotta A, Duronio V, Steinbrecher UP: Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels. J Biol Chem. 2003, 278: 24399-24408. 10.1074/jbc.M209179200
Article
CAS
PubMed
Google Scholar
Gomez-Munoz A, Kong J, Salh B, Steinbrecher UP: Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. FEBS Lett. 2003, 539: 56-60. 10.1016/S0014-5793(03)00197-2
Article
CAS
PubMed
Google Scholar
Granado MH, Gangoiti P, Ouro A, Arana L, Gomez-Munoz A: Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages. Biochim Biophys Acta. 2009, 1791: 263-272.
Article
CAS
PubMed
Google Scholar
Testai FD, Landek MA, Goswami R, Ahmed M, Dawson G: Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3, 4, 5-triphosphate in oligodendrocyte cell signaling. J Neurochem. 2004, 89: 636-644. 10.1046/j.1471-4159.2004.02374.x
Article
CAS
PubMed
Google Scholar
Scheid MP, Woodgett JR: Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett. 2003, 546: 108-112. 10.1016/S0014-5793(03)00562-3
Article
CAS
PubMed
Google Scholar
Scheid MP, Huber M, Damen JE, Hughes M, Kang V, Neilsen P, Prestwich GD, Krystal G, Duronio V: Phosphatidylinositol (3, 4, 5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3, 4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice. J Biol Chem. 2002, 277: 9027-9035. 10.1074/jbc.M106755200
Article
CAS
PubMed
Google Scholar
Sable CL, Filippa N, Hemmings B, Van Obberghen E: cAMP stimulates protein kinase B in a Wortmannin-insensitive manner. FEBS Lett. 1997, 409: 253-257. 10.1016/S0014-5793(97)00518-8
Article
CAS
PubMed
Google Scholar
Filippa N, Sable CL, Filloux C, Hemmings B, Van Obberghen E: Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol Cell Biol. 1999, 19: 4989-5000.
Article
PubMed Central
CAS
PubMed
Google Scholar
Van Kolen K, Gilany K, Moens L, Esmans EL, Slegers H: P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. Cell Signal. 2006, 18: 1169-1181. 10.1016/j.cellsig.2005.09.005
Article
CAS
PubMed
Google Scholar
Serhan CN, Haeggstrom JZ, Leslie CC: Lipid mediator networks in cell signaling: update and impact of cytokines. Faseb J. 1996, 10: 1147-1158.
CAS
PubMed
Google Scholar
Manna SK, Aggarwal BB: IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis. J Immunol. 1998, 161: 2863-2872.
CAS
PubMed
Google Scholar
Newton R, Hart L, Chung KF, Barnes PJ: Ceramide induction of COX-2 and PGE(2) in pulmonary A549 cells does not involve activation of NF-kappaB. Biochem Biophys Res Commun. 2000, 277: 675-679. 10.1006/bbrc.2000.3722
Article
CAS
PubMed
Google Scholar
Hayakawa M, Jayadev S, Tsujimoto M, Hannun YA, Ito F: Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2. Biochem Biophys Res Commun. 1996, 220: 681-686. 10.1006/bbrc.1996.0464
Article
CAS
PubMed
Google Scholar
Masini E, Giannini L, Nistri S, Cinci L, Mastroianni R, Xu W, Comhair SA, Li D, Cuzzocrea S, Matuschak GM, Salvemini D: Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation. J Pharmacol Exp Ther. 2008, 324: 548-557. 10.1124/jpet.107.131565
Article
CAS
PubMed
Google Scholar
Prasad VV, Nithipatikom K, Harder DR: Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes. Neurochem Int. 2008, 53: 220-229. 10.1016/j.neuint.2008.07.002
Article
CAS
PubMed
Google Scholar
Goggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schutze S: PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med. 2004, 10: 155-160. 10.1038/nm977
Article
PubMed
CAS
Google Scholar
Pettus BJ, Bielawska A, Subramanian P, Wijesinghe DS, Maceyka M, Leslie CC, Evans JH, Freiberg J, Roddy P, Hannun YA, Chalfant CE: Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem. 2004, 279: 11320-11326. 10.1074/jbc.M309262200
Article
CAS
PubMed
Google Scholar
Subramanian P, Stahelin RV, Szulc Z, Bielawska A, Cho W, Chalfant CE: Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine. J Biol Chem. 2005, 280: 17601-17607. 10.1074/jbc.M414173200
Article
CAS
PubMed
Google Scholar
Pettus BJ, Kitatani K, Chalfant CE, Taha TA, Kawamori T, Bielawski J, Obeid LM, Hannun YA: The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol. 2005, 68: 330-335.
CAS
PubMed
Google Scholar
Wijesinghe DS, Lamour NF, Gomez-Munoz A, Chalfant CE: Ceramide kinase and ceramide-1-phosphate. Methods Enzymol. 2007, 434: 265-292. full_text
Article
CAS
PubMed
Google Scholar
Granado MH, Gangoiti P, Ouro A, Arana L, Gonzalez M, Trueba M, Gomez-Munoz A: Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor. Cell Signal. 2009, 21: 405-412. 10.1016/j.cellsig.2008.11.003
Article
CAS
PubMed
Google Scholar
Gulbins E, Kolesnick R: Raft ceramide in molecular medicine. Oncogene. 2003, 22: 7070-7077. 10.1038/sj.onc.1207146
Article
CAS
PubMed
Google Scholar
Hendriks JJ, Teunissen CE, de Vries HE, Dijkstra CD: Macrophages and neurodegeneration. Brain Res Brain Res Rev. 2005, 48: 185-195. 10.1016/j.brainresrev.2004.12.008
Article
CAS
PubMed
Google Scholar
Condeelis J, Pollard JW: Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006, 124: 263-266. 10.1016/j.cell.2006.01.007
Article
CAS
PubMed
Google Scholar
Lankalapalli RS, Ouro A, Arana L, Gomez-Munoz A, Bittman R: Caged ceramide 1-phosphate analogues: synthesis and properties. J Org Chem. 2009, 74: 8844-8847. 10.1021/jo902076w
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim JW, Inagaki Y, Mitsutake S, Maezawa N, Katsumura S, Ryu YW, Park CS, Taniguchi M, Igarashi Y: Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1. Biochim Biophys Acta. 2005, 1738: 82-90.
Article
CAS
PubMed
Google Scholar
Graf C, Klumpp M, Habig M, Rovina P, Billich A, Baumruker T, Oberhauser B, Bornancin F: Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol Pharmacol. 2008, 74: 925-932. 10.1124/mol.108.048652
Article
CAS
PubMed
Google Scholar
Lavie Y, Cao H, Volner A, Lucci A, Han TY, Geffen V, Giuliano AE, Cabot MC: Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells. J Biol Chem. 1997, 272: 1682-1687. 10.1074/jbc.272.3.1682
Article
CAS
PubMed
Google Scholar
Cabot MC, Giuliano AE, Volner A, Han TY: Tamoxifen retards glycosphingolipid metabolism in human cancer cells. FEBS Lett. 1996, 394: 129-131. 10.1016/0014-5793(96)00942-8
Article
CAS
PubMed
Google Scholar
Goldsmith M, Avni D, Levy-Rimler G, Mashiach R, Ernst O, Levi M, Webb B, Meijler MM, Gray NS, Rosen H, Zor T: A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages. Immunology. 2008,
Google Scholar