Centers for Disease Control and Prevention. National Diabetes Fact Sheet: National estimates and General Information on Diabetes and Prediabetes in the United States, 2011. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2011. http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf. Accessed March 1, 2014.
Google Scholar
Saydah SH, Fradkin J, Cowie CC: Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA. 2004, 291: 335-42.
Article
CAS
PubMed
Google Scholar
Wachtel-Galor S, Tomlinson B, Benzie IF:Ganoderma lucidum (“Lingzhi”), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr. 2004, 2: 263-9. 10.1079/BJN20041039.
Article
Google Scholar
Russell R, Paterson M:Ganoderma-A therapeutic fungal biofactory. Phytochemistry. 2006, 67: 1985-2001. 10.1016/j.phytochem.2006.07.004.
Article
Google Scholar
Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS:Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009, 10: 717-42.
Article
CAS
PubMed
Google Scholar
Zhang W, Tang YJ: A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides. Biotechnol Prog. 2008, 24: 1249-61.
Article
CAS
PubMed
Google Scholar
Liu J, Kurashiki K, Shimizu K, Kondo R: 5 alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum. Biol Pharm Bull. 2006, 29: 392-5.
Article
PubMed
Google Scholar
Liu J, Shiono J, Shimizu K, Kukita A, Kukita AT, Kondo R: Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Bioorg Med Chem Lett. 2009, 19: 2154-7.
Article
CAS
PubMed
Google Scholar
Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E: Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum. Chem Biodivers. 2007, 4: 224-31.
Article
CAS
PubMed
Google Scholar
Liu X, Yuan JP, Chung CK, Chen XJ: Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum. Cancer Lett. 2002, 182: 155-61.
Article
CAS
PubMed
Google Scholar
Min BS, Gao JJ, Nakamura N, Hattori M: Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem Pharm Bull. 2000, 48: 1026-33.
Article
CAS
PubMed
Google Scholar
Xie YZ, Li SZ, Yee A, La Pierre DP, Deng ZQ, Lee DY:Ganoderma lucidum inhibits tumour cell proliferation and induces tumour cell death. Enzyme Microb Technol. 2006, 40: 177-85. 10.1016/j.enzmictec.2005.10.051.
Article
CAS
Google Scholar
Huie CW, Di X: Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components. J Chromatogr B. 2004, 812: 241-57. 10.1016/j.jchromb.2004.08.038.
Article
CAS
Google Scholar
Gao P, Hirano T, Chen Z, Yasuhara T, Nakata Y, Sugimoto A: Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum (reishi mushroom). Fitoterapia. 2012, 83: 490-9.
Article
CAS
PubMed
Google Scholar
Zheng J, Yang B, Yu Y, Chen Q, Huang T, Li D:Ganoderma lucidum polysaccharides exert anti-hyperglycemic effect on streptozotocin-induced diabetic rats through affecting β-cells. Comb Chem High Throughput Screen. 2012, 15: 542-50.
Article
CAS
PubMed
Google Scholar
Chevalier L, Bos C, Gryson C, Luengo C, Walrand S, Tomé D: High-protein diets differentially modulate protein content and protein synthesis in visceral and peripheral tissues in rats. Nutrition. 2009, 25: 932-9.
Article
CAS
PubMed
Google Scholar
Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH: Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice. Phytomedicine. 2009, 16: 426-36.
Article
CAS
PubMed
Google Scholar
Teng BS, Wang CD, Zhang D, Wu JS, Pan D, Pan LF: Hypoglycemic effect and mechanism of a proteoglycan from Ganoderma lucidum on streptozotocin-induced type 2 diabetic rats. Eur Rev Med Pharmacol Sci. 2012, 16 (2): 166-75.
CAS
PubMed
Google Scholar
Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ:Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015, 2: CD007259-
PubMed
Google Scholar
Winther K, Mehlsen J, Rein E, Hansen A, Goino T: A combination of Japanese ginseng, Ganoderma lucidum and trametes versicolor, referred to as the GOINO PROCEDURE, can lower blood glucose and LDL-cholesterol in patients with NIDDM. Atherosclerosis Suppl. 2003, 4: 339-10.1016/S1567-5688(03)91457-7.
Article
Google Scholar
Del Rio D, Stewart AJ, Pellegrini N: A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 2005, 15: 316-28.
Article
PubMed
Google Scholar
Victor VM: Mitochondrial Oxidative Stress in Diabetes. Diabetes: Oxidative Stress and Dietary Antioxidants. Chapter 5. Edited by: Preedy VR. 2014, 41-9. 10.1016/B978-0-12-405885-9.00005-X. Academic, London
Chapter
Google Scholar
Hafizur RM, Babiker R, Yagi S, Chishti S, Kabir N, Choudhary MI: The antidiabetic effect of Geigeria alata is mediated by enhanced insulin secretion, modulation of β-cell function and improvement of antioxidant activity in treptozotocin-induced diabetic rats. J Endocrinol. 2012, 214: 329-35.
Article
CAS
PubMed
Google Scholar
Hikino H, Konno C, Mirin Y, Hayashi T: Isolation and hypoglycemic activity of Ganoderans A and B, glycans of Ganoderma lucidum fruit bodies. Planta Med. 1985, 51: 339-40.
Article
CAS
PubMed
Google Scholar
Hikino H, Ishiyama M, Suzuki Y, Konno C: Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies. Planta Med. 1989, 55: 423-8.
Article
CAS
PubMed
Google Scholar
Jung KH, Ha E, Kim MJ, Uhm YK, Kim HK, Hong SJ:Ganoderma lucidum extract stimulates glucose uptake in L6 rat skeletal muscle cells. Acta Biochim Pol. 2006, 53: 597-601.
CAS
PubMed
Google Scholar
Ni T, Hu Y, Sun L, Chen X, Zhong J, Ma H: Oral route of mini-proinsulin-expressing Ganoderma lucidum decreases blood glucose level in streptozocin-induced diabetic rats. Int J Mol Med. 2007, 20: 45-51.
CAS
PubMed
Google Scholar
Krapivner S, Chernogubova E, Ericsson M, Ahlbeck-Glader C, Hamsten A, van’t Hooft FM: Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration. Diabetologia. 2007, 50: 94-102.
Article
CAS
PubMed
Google Scholar
Goldstein JL, DeBose-Boyd RA, Brown MS: Protein sensors for membrane sterols. Cell. 2006, 124: 35-46.
Article
CAS
PubMed
Google Scholar
Xie YH, Mo ZH, Chen K, Yang YB, Xing XW, Liao EY: Effect of different glucose concentrations on the expressions of insig-1 and insig-2 mRNA during the differentiation of 3T3-L1 cells. J Central South Uni [Article in Chinese]. 2008, 33: 238-44.
CAS
Google Scholar
Chen K, Jin P, He HH, Xie YH, Xie XY, Mo ZH: Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c. J Biomed Sci. 2011, 18: 57-
Article
PubMed Central
PubMed
Google Scholar
Espenshade PJ, Hughes AL: Regulation of sterol synthesis in eukaryotes. Annu Rev Genet. 2007, 41: 401-27.
Article
CAS
PubMed
Google Scholar
Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T: A common genetic variant is associated with adult and childhood obesity. Science. 2006, 312: 279-83.
Article
CAS
PubMed
Google Scholar
Horton JD, Goldstein JL, Brown MS: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002, 109: 1125-31.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jain SK, Rains JL, Croad JL: Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides and cholesterol levels in blood of streptozotocin-treated diabetic rats. Free Radic Biol Med. 2007, 43: 1124-31.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yang DW, Jia RH, Yang DP, Ding GH, Huang CX: Dietary hypercholesterolemia aggravates contrast media-induced nephropathy. Chin Med J (Engl). 2004, 117: 542-6.
Google Scholar
Lemhadri A, Hajji L, Michel JB, Eddouks M: Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats. J Ethnopharmacol. 2006, 106: 321-6.
Article
CAS
PubMed
Google Scholar
Sharma SB, Nasir A, Prabhu KM, Murthy PS: DevG Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol. 2003, 85: 201-6.
Article
CAS
PubMed
Google Scholar
Hiltunen JK, Qin Y: Beta-oxidation-strategies for the metabolism of a wide variety of acyl-CoA esters. Biochim Biophys Acta. 2000, 1484: 117-28.
Article
CAS
PubMed
Google Scholar
Kenneth J, Thomas D: Analysis of relative gene expression data using real-time quantitative PCR and the 2-44CT method. Methods. 2001, 25: 402-8. 10.1006/meth.2001.1262.
Article
Google Scholar
Michael W: A new mathematical model for relative quantification in real-time RT-PCR. Nucl Acid Res. 2001, 29: 2002-7.
Google Scholar