Open Access

Prevalence of dyslipidaemia and risk factors in Chinese coal miners: a cross-sectional survey study

  • Ye Fan1,
  • Jian-Jun Huang2,
  • Chen-Ming Sun2,
  • Nan Qiao3,
  • Hai-Xia Zhang4,
  • Hui Wang3,
  • Ran Tao3,
  • Ya-Nan Shen3 and
  • Tong Wang3Email author
Contributed equally
Lipids in Health and Disease201716:161

https://doi.org/10.1186/s12944-017-0548-9

Received: 18 December 2016

Accepted: 14 August 2017

Published: 23 August 2017

Abstract

Background

Although coal miners are susceptible to dyslipidaemia owing to their highly risky and stressful working environment as well as unhealthy lifestyle, very few studies have focused on this issue thus far. Therefore, this study investigated the current epidemiological characteristics of dyslipidaemia among Chinese coal miners.

Methods

Demographic, anthropometric, and biochemical data were gathered from 4341 coal miners in China. Dyslipidaemia was diagnosed based on the serum lipid levels. Univariate and multivariate logistic regression analyses were used to assess the related risk factors for dyslipidaemia.

Results

The average concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were 5.01 ± 0.93 mmol/L, 1.90 ± 1.72 mmol/L, 1.21 ± 0.35 mmol/L, and 3.15 ± 0.80 mmol/L, respectively. Additionally, 38.08% of participants had a high TC level, 25.84% had a low HDL-C level, 35.08% had a high LDL-C level, and 40.46% had a high TG level. The overall prevalence of dyslipidaemia was 68.28% (95% CI: 66.90–69.66%). Factors associated with dyslipidaemia were age, sex, marital status, monthly family income, type of work, length of service, smoking status, smoking index, drinking status, alcohol consumption per day, elevated fasting glucose, hypertension, obesity and abdominal obesity.

Conclusions

Our study’s results indicated a very high prevalence of dyslipidaemia among Chinese coal miners and identified various risk factors for dyslipidaemia.

Keywords

Dyslipidaemia Coal miners Prevalence Risk factors

Background

Cardiovascular disease (CVD) accounts for more than half of all non-communicable diseases and has become the leading cause of death worldwide [1]. Large cohort studies dating back to the Framingham Heart Study have identified cholesterol as a modifiable risk factor, which can be treated with lifestyle and pharmacological interventions [2]. Several clinical trials have demonstrated that treatment for dyslipidaemia is effective for preventing CVD [3, 4], and the treatment of dyslipidaemia can reduce the CVD risk by nearly 30% over a 5-year period [5].

Underground coal mining is still one of the most risky occupations globally. Data derived from decennial census and the experience of life insurance companies clearly revealed that death rates for American coal miners are among the highest of any occupational group. When the excess mortality due to respiratory diseases and accidents, which are recognized as hazards related to coal mining, is eliminated, mortality rates for coal miners remain high from 1.4 to 1.7 times the death rates for all workingmen. Excess mortality from other conditions, digestive disorders, certain cancers, and cardiovascular diseases may represent previously unrecognized risks related to coal mining [6]. As non-communicable diseases (NCDs) constitute an increasing portion of the global burden of disease, mining industry employees may be exposed to various factors potentially elevating their NCD risk. Underground coal miners work in a limited space and perform various tasks, and they constantly face a wide range of threats from physical factors, such as a high temperature, humidity, noise, vibration, and radiation [7]. Additionally, all these physical factors were related with NCD. Chronic occupational exposure to noise and vibration were associated with the excess mortality risk for acute myocardial infarction [8, 9]. Dust was also a significant physical factor that workers underground in the mining industry face, as short-term exposure to dust (eg. particulate matter 2.5) increases the risk for hospital admissions for cardiovascular and respiratory diseases [10]. Metabolic risk indicator rates were markedly high and increased significantly from baseline over the 5-year follow-up of a cohort of copper–gold mining company workers, with increased cholesterol, blood pressure, and blood glucose levels and overweight/obesity [11]. A study performed among workers from an open-cast iron ore mine in South Goa suggested an association between the occupation in mining with pneumoconiosis and hearing loss, and it showed that the prevalence rates of diabetes, hypertension, dyslipidaemia and polycythemia were 5.1, 8.3, 37.5, and 12.7%, respectively [12]. Aldehydes such as acrolein are ubiquitous pollutants present in automobile exhaust, cigarette, wood, and coal smoke. Oral exposure to acrolein could induce or exacerbate dyslipidaemia, as could increase levels of plasma cholesterol and triglycerides, thereby contributing to the risk of cardiovascular disease [13].

Owing to the long exposure to coal dust, coal miners are usually affected by disorders of lipid metabolism [14] and susceptible to CVDs [15]; in addition to their working environment, their lifestyle also plays an important role in their susceptibility to CVDs. Findings from open-pit workers indicated a relatively high incidence of hypertension (28%). The level of arterial hypertension is consistently associated with age, length of occupational experience, and body weight, and high prevalence of cardiovascular risk factors: alcohol consumption, cigarette smoking, family history, consumption of salty foods, and overweight among mining and milling workers [16]. The potential risk factors for dyslipidaemia include genetics, age, diet, smoking, physical activity, and stress [17]. Obviously, adopting a healthy lifestyle with proper medication can control these risk factors and their harmfulness to the body. Therefore, an important public health priority is to prevent dyslipidaemia and its related risk factors. Researchers have shown that the risk of CVD increases as the exposure to coal mine dust and other coal mine risk factors increases [15, 18], and an underground work environment in a coal mine is a risk factor for lipid metabolic abnormalities [19]. Therefore, knowledge of the current magnitude of dyslipidaemia in Chinese coal miners is important for enhanced occupational protection measures and prevention and management of CVD, in turn to effectively reduce occupational hazards. However, surveys to determine the burden of dyslipidaemia among Chinese coal miners have not been conducted in the last few years, and available data on the prevalence, types, and related factors of dyslipidaemia in this occupational population are rather limited and outdated. We hypothesized that remarkable changes in the prevalence, type, and risk factors of dyslipidaemia among Chinese coal miners would happen in recent years. Therefore, the purpose of this study was to obtain present data on dyslipidaemia, including its prevalence and risk factors, in coal miners in China.

Methods

Study population

Study participants were recruited from the Datong Coal Mine Group, with an estimated 200,000 permanent staff members at 87 coal mines. We obtained the baseline data of all staff from the administrative department of the coal mine group, which included the name, sex, date of birth, and work type to build the sampling frame. Based on these data, study subjects were selected using a two-stage cluster sampling. In the first phase, we randomly sampled 10 coal mines from 87 coal mines as the primary sampling unit. The number of permanent staff members in these sampled coal mines was approximately 38,951. In the second stage, stratified random sampling was applied according to the factors, including the work place (underground front-line, underground auxiliary and surface), age (20–65 years, with groups of 5-year intervals), and sex (male or female). SAS software, version 9.2 (SAS Institute, Cary, NC, USA) was used to perform Surveyselect procedure. The proportion of the sampling population was 11.2%. Considering no response or other non-compliance issues, we administered a questionnaire to 4400 miners, and 4341 of them returned completed questionnaires from August 1, 2013 to December 30, 2013.

Physical examinations

The physical examination was performed by trained physicians at the General Hospital of the Datong Coal Mining Group. With the subjects wearing light weight clothes and no shoes, their weight and height were measured using a height-measuring and weight-measuring instrument. We calculated the body mass index (BMI) by dividing weight in kilograms by height in meters squared. With the subjects standing and breathing normally, their waist circumference (WC) was measured at the umbilicus, and hip circumference was measured around the buttocks. The waist-hip ratio (WHR) was calculated using the following formula: waist circumference (cm)/hip circumference (cm).

Blood sample collection and biochemistry analysis

For all participants, fasting blood samples were collected in the morning after fasting at least 8 h. The lipid panel, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), serum fasting blood glucose (FBG), along with other routine blood biochemical indexes were determined by routine enzymatic methods on automated modular analysers (Siemens Advia 2400 Chemistry Analyser, Diamond Diagnostic, Holliston, MA, USA) at the General Hospital of the Datong Coal Mining Group.

Definitions of dyslipidaemia, obesity, FBG, and hypertension

TC, LDL-C, HDL-C, and TG levels were classified based on the 2016 Chinese guideline for the management of dyslipidaemia in adults [20]. Borderline high and high TC was defined as TC levels of 5.2–6.2 mmol/L (200–240 mg/dL) and ≥6.2 mmol/L (≥240 mg/dL), respectively, and a TC level < 5.2 mmol/L (<200 mg/dL) was defined as acceptable. Low HDL-C was defined as HDL-C levels <1.0 mmol/L (<40 mg/dL). Borderline high and high LDL-C was defined as LDL-C levels of 3.4–4.1 mmol/L (130–160 mg/dL) and ≥4.1 mmol/L (≥160 mg/dL), respectively, and LDL-C levels <3.4 mmol/L (130 mg/dL) and <2.6 mmol/L (100 mg/dL) were defined as acceptable and ideal, respectively. Borderline high and high TG was defined as TG levels of 1.7–2.3 mmol/L (150–200 mg/dL) and ≥2.3 mmol/L (≥200 mg/dL), respectively, and a TG level < 1.7 mmol/L (150 mg/dL) was defined as acceptable.

The Ministry of Health of China defines the following four categories of body weight based on BMI values: underweight, <18.5 kg/m2; normal weight, 18.5–23.9 kg/m2; overweight, 24.0–27.9 kg/m2; and obesity, ≥28.0 kg/m2 [21]. When the WCs are ≥88 cm for women and ≥102 cm for men, individuals are considered to have “abdominal obesity”. In addition, hypso-WHR is defined when the WHRs are >0.9 for men and >0.8 for women [22].

According to the American Diabetes Association, study participants were categorised into three groups based on FBG levels [23]: normal fasting glucose (NFG; FBG < 5.6 mmol/L (100 mg/dL)), impaired fasting glucose (IFG; 5.6 mmol/L (100 mg/dL) ≤ FBG < 7.0 mmol/L (126 mg/dL)), and diabetes mellitus (DM; FBG ≥ 7.0 mmol/L (126 mg/dL)).

After avoiding exercise and caffeinated beverages for at least one-half hour before measuring blood pressure, the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the participants were obtained using a mercury sphygmomanometer (GB3053–93 Yuyue, Armamentarium Limited Company, Jiangsu, China). A high blood pressure was defined as a SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg [24].

Questionnaire

A survey was conducted by trained investigators after the physical examination. Data were collected by gathering all participants in a conference room along with cardiologists and trained nurses. All participants agreed to participate in a face-to-face interview using a standard questionnaire. Participants’ social demographic characteristics (sex, age, etc.), work situation (workplace, work type, etc.), lifestyle and behaviours, medical history, smoking and drinking status, dietary habits, monthly family income, marital status, and educational level were determined by the structured questionnaire.

Statistical analyses

Data entry was conducted using EpiData 3.0 software (EpiData Association, Odense, Denmark), and to reduce error in generating an electronic data set, we used double data entry. Descriptive analyses of all variables were performed (mean ± standard deviation for continuous data and frequencies or percentages for categorical variables). Comparisons of continuous variables were made using the unpaired Student’s t test. The Pearson’s chi-square test was used to evaluate differences in the categorical variables. Furthermore, the prevalence of an abnormal lipid panel according to various characteristics was calculated. Univariate and multivariate logistic regression analyses adjusted for age and sex were used to evaluate the association between blood lipid levels and risk factors, with abnormal TC, TG, HDL-C, and LDL-C levels as dependent variables and demographic characteristics, working characteristics, lifestyles and behaviours, anthropometric characteristics, and biochemical indices as independent variables (entry = 0.05, removal = 0.10). The association between dyslipidaemia and risk factors was assessed by odds ratios (ORs), and the adjusted ORs were presented with 95% confidence intervals. To further assess major risk factors for the prevalence of dyslipidaemia and control for potential confounders, we performed stepwise multiple logistic regression analysis to identify the risk factors for each type of dyslipidaemia, adjusted for age and sex. SAS software, version 9.4 (SAS Institute, Cary, NC, USA) was used to perform all statistical analyses. There was a significance difference when P < 0.05, and all P-values were two-tailed.

Ethical considerations

This study was approved by the ethics committee of Shanxi Medical University (ethical application reference: HX201201). All study processes were conducted according to the ethical criteria. After all participants were informed of the study’s purpose, medical programs, benefits, and non-disclosure agreement of individual information, they signed a written consent.

Results

Characteristics of the study population

Overall, 4341 coal miners from 10 coal mines were sampled. The survey population accounted for 2.2% of the total participants. The mean (standard deviation) age of the subjects was 41.79 (8.64) years, and men accounted for 84.22% (3656/4341) of the population. There were 908 (21.01%) underground front-line participants, 1497 (34.64%) underground auxiliary participants, 1118 (25.87%) ground participants and 798 (18.47%) office participants. The mean levels of TC, TG, HDL-C, and LDL-C were 5.01 ± 0.93 mmol/L, 1.90 ± 1.72 mmol/L, 1.21 ± 0.35 mmol/L, and 3.15 ± 0.80 mmol/L, respectively. Demographic, clinical, and work characteristics of participants enrolled in this cross-sectional occupational population-based survey according to their dyslipidaemia status are shown in Table 1. The percentages of men, married participants, drinkers and smokers were all significantly higher in the dyslipidaemia group than in the control group, whereas the percentages of intense physical workers and underground front-line workers were lower (P < 0.001, except P < 0.05 for marital status and workplace). The dyslipidaemia group was older; had a higher FBG, SBP, DBP, BMI, waist circumferences, WHR, TC level, TG level, and LDL-C level; and had a lower HDL-C level compared to the non-dyslipidaemia group (all P < 0.001).
Table 1

Characteristics of participants according to dyslipidemia status

Characteristics

All subjects

With dyslipidemia

Without dyslipidemia

t/χ2

P value

  

Overall

High TG (≥1.7 mmol/L)

High TC (≥5.2 mmol/L)

High LDL-C(≥3.4 mmol/L)

Low HDL-C (<1.0 mmol/L)

   

All, n (%)

4341(100)

2964(68.28)

1746(40.46)

1643(38.08)

1523(35.08)

1115(25.84)

1377(31.72)

  

Age (years), mean (SD)

41.79(8.64)

42.42(8.57)

42.46(8.34)

43.09(8.36)

43.20(8.49)

41.22(8.91)

40.43(8.64)

−7.11

<0.001

Male, n (%)

3656(84.22)

2609(71.36)

1584(43.46)

1411(38.71)

1334(36.49)

1045(28.67)

1047(28.64)

102.27

<0.001

Married, n (%)

4057(93.80)

2792(68.82)

1664(41.28)

1551(38.48)

1440(35.49)

1034(25.65)

1265(31.18)

9.65

0.002

Education, n (%)

 Primary school or under

116(2.69)

80(68.97)

48(41.38)

47(40.52)

40(34.48)

29(25.00)

36(31.03)

0.41

0.939

 Junior high school

1092(25.29)

738(67.58)

428(39.74)

435(40.39)

390(35.71)

240(22.28)

354(32.42)

  

 Junior college or Senior high school

2601(60.24)

1784(68.59)

1059(40.87)

967(37.32)

917(35.26)

687(26.51)

817(31.41)

  

 Bachelor degree or above

509(11.79)

346(67.98)

205(40.35)

182(35.83)

166(32.61)

156(30.71)

163(32.02)

  

Monthly income (RMB, Yuan), n (%)

  ≤ 4000   

1127(26.28)

774(68.68)

436(39.00)

438(39.18)

399(35.40)

305(27.28)

353(31.32)

1.39

0.499

 4000–6000

1803(42.05)

1240(68.77)

752(41.94)

722(40.27)

662(36.72)

408(22.76)

563(31.23)

  

 >6000

1358(31.67)

909(66.94)

537(39.75)

455(33.68)

439(32.33)

395(29.24)

449(33.06)

  

Working type, n (%)

 Intense physical workers

1124(26.28)

708(62.99)

390(34.98)

404(36.23)

355(31.58)

238(21.35)

416(37.01)

22.61

<0.001

 Light physical workers

2095(48.98)

1491(71.17)

906(43.56)

803(38.61)

753(35.94)

596(28.65)

604(28.83)

  

 Mental workers

1058(24.74)

721(68.15)

428(40.53)

404(38.26)

389(36.77)

268(25.38)

337(31.85)

  

Workplace, n (%)

 Underground front-line

908(21.01)

580(63.88)

321(35.55)

311(34.44)

288(31.72)

209(23.15)

328(36.12)

16.13

0.001

 Underground auxiliary

1497(34.64)

1063(71.01)

671(45.00)

568(38.10)

519(34.67)

414(27.77)

434(28.99)

  

 Ground

1118(25.87)

785(70.21)

437(39.09)

464(41.50)

425(38.01)

304(27.19)

333(29.79)

  

 Office

798(18.47)

532(66.67)

314(39.35)

297(37.22)

290(36.34)

188(23.56)

266(33.33)

  

 Habitual drinking, n(%)

1795(41.49)

1329(74.04)

838(46.84)

762(42.59)

660(36.77)

442(24.71)

466(25.96)

46.91

<0.001

 Current smoking, n(%)

2495(57.69)

1815(72.75)

1090(43.79)

1006(40.42)

948(38.00)

722(29.01)

680(27.25)

54.35

<0.001

 FBG (mmol/L), mean (SD)

5.00(1.30)

5.10(1.47)

5.16(1.57)

5.22(1.53)

5.23(1.55)

5.09(1.61)

4.78(0.78)

−9.28

<0.001

 SBP(mmHg), mean (SD)

126.95(17.62)

129.0(17.40)

130.3(17.56)

129.7(17.74)

129.8(17.68)

128.2(16.61)

122.6 (17.31)

−11.27

<0.001

 DBP(mmHg), mean (SD)

78.85(14.18)

80.56(14.18)

81.93(14.37)

80.67(14.42)

81.04(14.27)

80.72(14.02)

75.17(13.46)

−12.01

<0.001

 BMI (kg/m2), mean (SD)

24.92(5.97)

25.56(3.63)

26.27(3.67)

25.37(3.50)

25.81(3.44)

26.41(3.78)

23.52(9.01)

−8.05

<0.001

 WC (cm), mean (SD)

89.97(9.81)

91.76(9.51)

93.30(9.17)

91.40(9.61)

92.06(9.47)

93.71(8.91)

86.09(9.34)

−18.16

<0.001

 WHR, mean (SD)

0.89(0.08)

0.90(0.07)

0.91(0.07)

0.90(0.07)

0.90(0.06)

0.91(0.07)

0.88(0.09)

−8.4

<0.001

 TC (mmol/L), mean (SD)

5.01(0.93)

5.28(0.96)

5.29(0.98)

5.94(0.67)

5.85(0.74)

4.73(0.94)

4.41(0.49)

−39.85

<0.001

 TG (mmol/L), mean (SD)

1.90(1.72)

2.31(1.92)

3.09(2.18)

2.41(2.36)

2.15(1.61)

2.71(2.37)

1.00(0.31)

−36.1

<0.001

 HDL-C (mmol/L), mean (SD)

1.21(0.35)

1.15(0.36)

1.07(0.30)

1.30(0.38)

1.21(0.31)

0.83(0.14)

1.36(0.26)

21.34

<0.001

 LDL-C (mmol/L), mean (SD)

3.15(0.80)

3.41(0.77)

3.37(0.79)

3.84(0.64)

3.99(0.51)

3.10(0.71)

2.57(0.47)

−43.51

<0.001

P-value for comparison between subjects with and without dyslipidemia at α = 0.05 level

FBG fasting blood glucose, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, WC waist circumferenc

WHR waist/hip ratio, H-TC high total cholesterol, H-TG high triglyceride, H-LDL high low-density lipoprotein cholesterol, L-HDL low high-density lipoprotein cholesterol

Prevalence of dyslipidaemia

As shown in Tables 1 and 2, 68.28% (95% CI: 66.90–69.66%) of Chinese coal miners had at least one type of dyslipidaemia (including borderline high and high TC, LDL-C, and TG levels and a low HDL-C level; men, 71.36%; women, 51.68%). Analysis of the dyslipidaemia components showed that 38.08% of the population had a high TC level, 40.46% had a high TG level, 35.08% had an increased LDL-C level, and 25.84% had an abnormally low HDL-C level. The prevalence rates of borderline high and high TC levels were 27.69 and 10.38%, respectively; those of borderline high and high LDL-C levels were 23.15 and 11.93%, respectively; that of a low HDL-C level was 25.84%; and those of borderline high and high TG levels were 16.22 and 24.24%, respectively. The age-specific prevalence of borderline high and high TC, LDL-C, and TG levels increased with increasing age (P < 0.001). The prevalences of borderline high and high TC, LDL-C, and TG levels and a low HDL-C level were significantly higher in men than in women, but they were significantly lower in the underground than in the surface workplace and lower in the intense physical work type (P < 0.05).
Table 2

Proportion of concentrations classification of TC, TG, HDL-C and LDL-C in Chinese coal miners (mmol/L)

Variable (Characteristics)

TC

LDL-C

HDL-C

TG

 

<5.2

5.2–6.2

≥6.2

<2.6

2.6–3.4

3.4–4.1

≥4.1

<1.0

≥1.0

<1.7

1.7–2.3

≥2.3

All, n(%)

2672(61.92)

1195(27.69)

448(10.38)

1143(26.33)

1675(38.59)

1005(23.15)

518(11.93)

1115(25.84)

3200(74.16)

2569(59.54)

700(16.22)

1046(24.24)

Age(years), n(%)

  < 40

1254(66.88)

471(25.12)

150(8.00)

559(29.72)

754(40.09)

370(19.67)

198(10.53)

509(27.15)

1366(72.85)

1170(62.40)

285(15.20)

420(22.40)

  ≥ 40

1418(58.11)

724(29.67)

298(12.21)

584(23.74)

921(37.44)

635(25.81)

320(13.01)

606(24.84)

1834(75.16)

1399(57.34)

415(17.01)

626(25.66)

P value

<0.001

  

<0.001

   

0.086

 

0.001

  

Gender, n(%)

 Male

2234(61.29)

1024(28.09)

387(10.62)

913(24.97)

1409(38.54)

876(23.96)

458(12.53)

1045(28.67)

2600(71.33)

2061(56.54)

617(16.93)

967(26.53)

 Female

438(65.47)

171(25.56)

60(8.97)

230(33.63)

266(38.89)

128(18.71)

60(8.77)

70(10.46)

599(89.54)

508(75.93)

83(12.41)

78(11.66)

P value

0.04

  

<0.001

   

<0.001

 

<0.001

  

Working type, n(%)

 Intense physical workers

711(63.77)

305(27.35)

99(8.88)

323(28.74)

446(39.68)

242(21.53)

113(10.05)

238(21.35)

877(78.65)

725(65.02)

164(14.71)

226(20.27)

 Light physical workers

1277(61.39)

577(27.74)

226(10.87)

539(25.73)

803(38.33)

499(23.82)

254(12.12)

596(28.65)

1484(71.35)

1174(56.44)

357(17.16)

549(26.39)

 Mental workers

652(61.74)

292(27.65)

112(10.61)

267(25.24)

402(38.00)

247(23.35)

142(13.42)

268(25.38)

788(74.62)

628(59.47)

175(16.57)

253(23.96)

P value

0.205

  

0.007

   

<0.001

 

<0.001

  

Workpalce, n(%)

 Underground

592(65.56)

232(25.69)

79(8.75)

266(29.30)

354(38.99)

200(22.03)

88(9.69)

209(23.15)

694(76.85)

582(64.45)

122(13.51)

199(22.04)

 Front-line

 Underground auxiliary

923(61.90)

416(27.90)

152(10.19)

360(24.05)

618(41.28)

341(22.78)

178(11.89)

414(27.77)

1077(72.23)

820(55.00)

272(18.24)

399(26.76)

 Ground

654(58.50)

333(29.79)

131(11.72)

293(26.21)

400(35.78)

278(24.87)

147(13.15)

304(27.19)

814(72.81)

681(60.91)

174(15.56)

263(23.52)

 Office

501(62.78)

211(26.44)

86(10.78)

208(26.07)

300(37.59)

185(23.18)

105(13.16)

188(23.56)

610(76.44)

484(60.65)

131(16.42)

183(22.93)

P value

0.011

  

0.015

   

0.023

 

<0.001

  

Data are n (%). TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride

Factors associated with dyslipidaemia

The prevalence rate of abnormal serum lipid concentrations in accordance with participants’ different demographic, work, lifestyle, and behaviour characteristics and the results of univariate logistic analyses of factors associated with dyslipidaemia adjusted by age and sex are presented in Tables 3 and 4, respectively. Notably, the high TC, LDL-C, and TG prevalence significantly increased with advanced age (≥40 years), but the low HDL-C prevalence decreased (adjusted ORs = 1.45, 1.45, 1.19, and 0.85, respectively; P < 0.05). The ORs for a high LDL-C level, high TG level, and low HDL-C level were lower among women(adjusted ORs = 0.68, 0.42, and 0.29, respectively; P < 0.001). Only the high prevalence of high TG levels was related to the marital status: married participants had a higher OR of high TG levels than single participants (adjusted OR = 1.63; P < 0.001). Subjects with a high family income were more likely to have lower ORs of high TC level (>6000 yuan: adjusted OR = 0.79; P < 0.05) and low HDL-C level (4000–6000 yuan: adjusted OR = 0.66; P < 0.001).
Table 3

Prevalence of dyslipidemia by demographic and working characteristics and adjusted odds ratios (95%CI) of dyslipidemia prevalence

Variable

Characteristics

High TC(≥5.2 mmol/L)

High LDL-C(≥3.4 mmol/L)

Low HDL-C (<1.0 mmol/L)

High TG(≥1.7 mmol/L)

Adjusted

P

Adjusted

P

Adjusted

P

Adjusted

P

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Age(years)

<40

1

 

1

 

1

 

1

 

≥40

1.45(1.27, 1.64)

<0.001

1.45(1.27, 1.64)

<0.001

0.85(0.74, 0.97)

0.018

1.19(1.05, 1.35)

0.005

Gender

Male

1

 

1

 

1

 

1

 

Female

0.86(0.72, 1.02)

0.09

0.68 (0.56, 0.81)

<0.001

0.29(0.22, 0.37)

<0.001

0.42(0.35, 0.51)

<0.001

Marital status

Single

1

 

1

 

1

 

1

 

Married

1.22(0.93, 1.60)

0.152

1.18(0.90, 1.56)

0.238

0.87(0.66, 1.16)

0.351

1.63(1.23, 2.15)

<0.001

Education

Primary school or under

1

 

1

 

1

 

1

 

Junior high school

1.05(0.71, 1.55)

0.805

1.13(0.75, 1.69)

0.564

0.87(0.56, 1.36)

0.536

0.98(0.66, 1.45)

0.918

Junior college or Senior high school

1.03(0.70, 1.51)

0.896

1.25(0.84, 1.85)

0.273

1.12(0.72, 1.74)

0.608

1.13(0.77, 1.66)

0.529

Bachelor degree or above

1.04(0.68, 1.59)

0.851

1.23(0.79, 1.89)

0.357

1.48 (0.92, 2.37)

0.108

1.23(0.80, 1.87)

0.345

Monthly income

≤4000

1

 

1

 

1

 

1

 

(RMB, Yuan)

4000–6000

1.02(0.87, 1.19)

0.793

0.99(0.85, 1.17)

0.96

0.66(0.55, 0.79)

<0.001

0.99(0.85, 1.16)

0.956

>6000

0.79(0.67, 0.94)

0.006

0.86(0.73, 1.02)

0.084

1.01(0.84, 1.21)

0.946

0.98(0.83, 1.16)

0.814

Working type

Intense physical workers

1

 

1

 

1

 

1

 

Light physical workers

1.14(0.98, 1.32)

0.102

1.29(1.10, 1.51)

0.001

1.68(1.41, 1.99)

<0.001

1.60(1.38, 1.87)

<0.001

Mental workers

1.18(0.98, 1.42)

0.079

1.48(1.23, 1.79)

<0.001

1.73(1.41, 2.13)

<0.001

1.70(1.41, 2.04)

<0.001

Workplace

Underground front-line

1

 

1

 

1

 

1

 

Underground auxiliary

1.17(0.98, 1.39)

0.08

1.14(0.96, 1.36)

0.147

1.29(1.06, 1.56)

0.01

1.49(1.25, 1.76)

<0.001

 

Ground

1.41(1.17, 1.71)

<0.001

1.49(1.23, 1.81)

<0.001

1.76(1.43, 2.18)

<0.001

1.50(1.24, 1.81)

<0.001

Office

1.22(0.98, 1.51)

0.073

1.49(1.20, 1.85)

<0.001

1.68(1.33, 2.14)

<0.001

1.73(1.40, 2.14)

<0.001

Length of service

≤3 years

1

 

1

 

1

 

1

 
 

4–10 years

1.26(0.82, 1.95)

0.29

1.39(0.89, 2.18)

0.152

1.14(0.75, 1.72)

0.552

0.99(0.66, 1.48)

0.959

>10 years

1.87(1.25, 2.79)

0.002

1.98(1.30, 3.02)

0.001

0.87(0.59, 1.29)

0.496

1.39(0.96, 2.01)

0.083

TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride

Table 4

Prevalence of dyslipidemia by lifestyle and behavior characteristics and adjusted odds ratios (95%CI) of dyslipidemia prevalence

Variable

Characteristics

High TC (≥5.2 mmol/L)

High LDL-C (≥3.4 mmol/L)

Low HDL-C (<1.0 mmol/L)

High TG (≥1.7 mmol/L)

Adjusted

P

Adjusted

P

Adjusted

P

Adjusted

P

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Smoking status

No

1

 

1

 

1

 

1

 
 

Yes

1.28(1.10, 1.48)

0.001

1.24(1.07, 1.44)

0.004

1.06(0.91, 1.24)

0.48

1.05(0.91, 1.21)

0.472

Smoking index

(roots*years)

0~

1

 

1

 

1

 

1

 

150~

1.41(1.17, 1.70)

<0.001

1.34(1.11, 1.61)

0.002

0.98(0.80, 1.20)

0.847

1.07(0.89, 1.29)

0.454

300~

1.18(0.95, 1.47)

0.13

1.22(0.98, 1.52)

0.076

1.00(0.79, 1.27)

0.979

1.07(0.86, 1.32)

0.562

450~

1.35(1.12, 1.62)

0.001

1.37(1.14, 1.65)

<0.001

1.21(0.99, 1.48)

0.064

1.15(0.96, 1.38)

0.142

Passive smoking

No

1

 

1

 

1

 

1

 

Yes

1.09(0.95, 1.25)

0.228

1.11(0.96, 1.27)

0.152

1.11(0.95, 1.30)

0.189

1.11(0.97, 1.28)

0.133

Alcohol Drinking Status

No

1

 

1

 

1

 

1

 

Yes

1.39(1.21, 1.58)

<0.001

1.04(0.91, 1.18)

0.612

0.70(0.61, 0.81)

<0.001

1.33(1.17, 1.52)

<0.001

Daily drinking(g)

0~

1

 

1

 

1

 

1

 

25~

1.52(1.19, 1.96)

0.001

1.08(0.83, 1.39)

0.572

0.69(0.52, 0.93)

0.013

1.10(0.85, 1.41)

0.479

50~

1.99(1.46, 2.71)

<0.001

1.29(0.95, 1.75)

0.107

0.38(0.25, 0.58)

<0.001

0.99(0.72, 1.34)

0.923

75~

1.89(1.45, 2.45)

<0.001

0.90(0.69, 1.18)

0.449

0.49(0.35, 0.68)

<0.001

1.67(1.28, 2.17)

<0.001

Sleep time

Sufficient(> = 8 h)

1

 

1

 

1

 

1

 

Insufficient(<8 h)

0.98(0.86, 1.11)

0.745

0.96(0.85, 1.09)

0.554

0.89(0.78, 1.03)

0.111

0.95(0.83, 1.07)

0.38

Eat speed

Fast

1

 

1

 

1

 

1

 

Moderate

1.05(0.92, 1.20)

0.441

0.92(0.80, 1.05)

0.208

0.78(0.68, 0.91)

0.001

0.88(0.77, 1.00)

0.052

Slow

1.07(0.86, 1.34)

0.554

0.83(0.66, 1.04)

0.105

0.55(0.42, 0.72)

<0.001

0.72(0.58, 0.90)

0.005

TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride

Participants who did light physical and mental work were more likely to have higher ORs of high LDL-C levels (adjusted ORs = 1.29, 1.48, respectively; P < 0.05), high TG levels (adjusted ORs = 1.60, 1.70, respectively; P < 0.001) and low HDL-C levels (adjusted ORs = 1.68, 1.73, respectively; P < 0.001) than those who did intense physical labour. Further, compared to the underground front-line work group, the surface work place group were more inclined to suffer from high TC (ground: adjusted OR =1.41; P < 0.001), high LDL-C (ground: adjusted OR =1.49; P < 0.001; office: adjusted OR =1.49; P < 0.001), high TG (adjusted ORs for underground auxiliary, ground and office =1.49, 1.50, 1.73, respectively; P < 0.001) and low HDL-C (adjusted ORs for underground auxiliary, ground and office =1.29, 1.76, 1.68, respectively; P < 0.05). Additionally, having an extended length of service (>10 years of service) increased the tendency of high TC (adjusted OR =1.87; P < 0.05) and high LDL-C levels (adjusted OR =1.98; P < 0.05).

Cigarette smoking and the prevalence of high TC and high LDL-C levels showed a positively relationship (adjusted ORs = 1.28 and 1.24, respectively; P < 0.05). In addition, participants with a bigger smoking index had a greater prevalence of high TC (150 ~ and 450~: adjusted ORs = 1.41 and 1.35, respectively; P < 0.05) and high LDL-C levels (150 ~ and 450~: adjusted ORs = 1.34 and 1.37, respectively; P < 0.05). The prevalence of high TC and high TG levels was higher among current drinkers than non-drinkers, but the trend was opposite for low HDL-C levels (adjusted ORs = 1.39, 1.33, and 0.70, respectively; P < 0.001). The daily alcohol consumption was positively associated with a high prevalence rate of elevated TC levels (25 ~ g/d, 50 ~ g/d and 75 ~ g/d: adjusted ORs =1.52, 1.99, and 1.89, respectively; P < 0.05) and elevated TG levels (75 ~ g/d: adjusted OR = 1.67; P < 0.001), but it was inversely related to the prevalence of low HDL-C levels (25 ~ g/d, 50 ~ g/d, and 75 ~ g/d: adjusted ORs = 0.69, 0.38 and 0.49, respectively; P < 0.05). Participants with a slower eating speed had lower ORs of low HDL-C levels (moderate and slow eating speed: adjusted ORs = 0.78 and 0.55, respectively; P < 0.05) and elevated TG levels (slow eating speed: adjusted OR = 0.72; P < 0.05) than participants who had a faster eating speed. Furthermore, there was no significant association of the prevalence of any kind of dyslipidaemia with education level, passive smoking, and sleep time.

Results of univariate logistic analyses of the anthropometric and biochemistry indices associated with dyslipidaemia, adjusted by age and sex, are shown in Table 5. Participants who had elevated fasting glucose levels were more likely to have a higher prevalence rate of high TC levels (IFG: adjusted OR = 1.55, DM: adjusted OR = 2.32; P < 0.001), high LDL-C levels (IFG: adjusted OR = 1.40, DM: adjusted OR = 2.06; P < 0.05), high TG levels (IFG: adjusted OR = 1.80, DM: adjusted OR = 3.28; P < 0.001) and low HDL-C levels (DM: adjusted OR = 1.96; P < 0.001). Subjects with hypertension had an increased tendency of high TC levels (SBP: adjusted OR = 1.38, DBP: adjusted OR = 1.45; P < 0.001), high LDL-C levels (SBP: adjusted OR = 1.36, DBP: adjusted OR = 1.47; P < 0.001), high TG levels (SBP: adjusted OR = 1.65, DBP: adjusted OR = 1.99; P < 0.001), and low HDL-C levels (DBP: adjusted OR = 1.24; P < 0.05). Additionally, participants with a large body size had a greater prevalence of high TC levels (overweight: adjusted OR = 1.50, obese: adjusted OR = 1.73; P < 0.001), high LDL-C levels (overweight: adjusted OR = 1.86, obese: adjusted OR = 2.56; P < 0.001), low HDL-C levels (overweight: adjusted OR = 2.09, obese: adjusted OR = 3.77; P < 0.001), and high TG levels (overweight: adjusted OR = 2.92, obese: adjusted OR = 5.16; P < 0.001). Participants with central obesity tended to suffer high TC levels (large waist: adjusted OR = 1.30, hypso-WHR: adjusted OR = 1.28; P < 0.05), high LDL-C levels (large waist: adjusted OR = 1.54, hypso-WHR: adjusted OR = 1.41; P < 0.001), low HDL-C levels (large waist: adjusted OR = 2.48, hypso-WHR: adjusted OR = 1.74; P < 0.001), and high TG levels (large waist: adjusted OR = 2.86, hypso-WHR: adjusted OR = 1.95; P < 0.001).
Table 5

Prevalence of dyslipidemia by anthropometric and biochemical parameters and adjusted odds ratios (95%CI) of dyslipidemia prevalence

Variable

Characteristics

High TC (≥5.2 mmol/L)

High LDL-C (≥3.4 mmol/L)

Low HDL-C (<1.0 mmol/L)

High TG (≥1.7 mmol/L)

Adjusted OR

P

Adjusted OR

P

Adjusted OR

P

Adjusted OR

P

(95% CI)

(95% CI)

(95% CI)

(95% CI)

FBG

NFG(<5.6 mmol/L)

1

 

1

 

1

 

1

 

IFG(5.6 mmol/L ≤ FBG < 7.0 mmol/L)

1.55(1.28, 1.89)

<0.001

1.40(1.15, 1.71)

0.001

1.08(0.86, 1.34)

0.515

1.80(1.48, 2.19)

<0.001

DM(≥7.0 mmol/L)

2.32(1.70, 3.17)

<0.001

2.06(1.51, 2.80)

<0.001

1.96(1.42, 2.70)

<0.001

3.28(2.35, 4.57)

<0.001

SBP

<140 mmHg

1

 

1

 

1

 

1

 

≥140 mmHg

1.38(1.19, 1.61)

<0.001

1.36(1.16, 1.58)

<0.001

1.11(0.93, 1.31)

0.242

1.65(1.42, 1.93)

<0.001

DBP

<90 mmHg

1

 

1

 

1

 

1

 
 

≥90 mmHg

1.45(1.25, 1.69)

<0.001

1.47(1.26, 1.70)

<0.001

1.24(1.05, 1.46)

0.01

1.99(1.71, 2.31)

<0.001

BMI

normal weight, 18.5–23.9 kg/m2

1

 

1

 

1

 

1

 

underweight, <18.5 kg/m2

0.99(0.67, 1.46)

0.946

0.65(0.41, 1.03)

0.067

0.56(0.30, 1.03)

0.064

1.10(0.72, 1.68)

0.665

overweight, 24.0–27.9 kg/m2

1.50(1.30, 1.72)

<0.001

1.86(1.61, 2.16)

<0.001

2.09(1.77, 2.48)

<0.001

2.92(2.51, 3.39)

<0.001

obesity, ≥28.0 kg/m2

1.73(1.45, 2.07)

<0.001

2.56(2.14, 3.07)

<0.001

3.77(3.09, 4.59)

<0.001

5.16(4.28, 6.22)

<0.001

WC

<102 cm (male)/88 cm (female)

1

 

1

 

1

 

1

 

≥102 cm (male)/88 cm (female)

1.30(1.08, 1.56)

0.005

1.54(1.28, 1.86)

<0.001

2.48(2.03, 3.03)

<0.001

2.86(2.36, 3.46)

<0.001

WHR

≤0.9(male)/0.8 (female)

1

 

1

 

1

 

1

 

>0.9(male)/0.8 (female)

1.28(1.13, 1.46)

<0.001

1.41(1.23, 1.60)

<0.001

1.74(1.50, 2.00)

<0.001

1.95(1.71, 2.22)

<0.001

FBG fasting blood glucose, NFG normal fasting glucose, IFG impaired fasting glucose, DM diabetes mellitus, TG, triglyceride, TC, total Cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, WC waist circumference, WHR waist/hip ratio

Results of multivariable logistic regression analysis of dyslipidaemia

Data in Table 6 suggest that the presence of high TC levels was still positively associated with an extended length of service (>10 years: adjusted OR = 1.70; P < 0.05), smoking status (adjusted OR = 1.25; P < 0.05), increased alcohol consumption (25 ~ g/d, 50 ~ g/d and 75 ~ g/d: adjusted ORs = 1.53, 1.81 and 1.73, respectively; P < 0.05), elevated fasting glucose (IFG: adjusted OR = 1.41; P < 0.05; DM: adjusted OR = 1.99; P < 0.001), hypertension (DBP: adjusted OR = 1.23; P < 0.05), and bigger body size (overweight: adjusted OR = 1.43, obese: adjusted OR = 1.66; P < 0.001), but it was inversely related to the monthly family income (>6000 yuan: adjusted OR = 0.76; P < 0.05). Participants who engaged in mental labour (adjusted OR = 1.35; P < 0.05), had an extended length of service (>10 years: adjusted OR = 1.77; P < 0.05), higher smoking index (150~, 300 ~ and 450~: adjusted ORs = 1.39, 1.28, and 1.42, respectively; P < 0.05), elevated fasting glucose (DM: adjusted OR = 1.61; P < 0.05), hypertension (DBP: adjusted OR = 1.30; P < 0.05), or bigger body size (overweight: adjusted OR = 1.77, obese: adjusted OR = 2.35; P < 0.001) had an increased tendency of a high LDL-C level. Table 6 also illustrates that participants who were married (adjusted OR = 1.43; P < 0.05), engaged in light physical or mental labour (adjusted ORs = 1.51 and 1.58, respectively; P < 0.001), drinking (adjusted OR =1.24; P < 0.05), had increased alcohol consumption (75 ~ g/d: adjusted OR = 1.37; P < 0.05), elevated fasting glucose (IFG: adjusted OR = 1.46; DM: adjusted OR = 2.32; P < 0.001), hypertension (DBP: adjusted OR = 1.58; P < 0.001), bigger body size (overweight: adjusted OR = 2.61, obese: adjusted OR = 3.55; P < 0.001), or abdominal obesity (large waist: adjusted OR = 1.41, hypso-WHR: adjusted OR = 1.25; P < 0.05) were more inclined to have high TG levels than those without these conditions; however, the trend was opposite for women (adjusted OR = 0.41; P < 0.001). Performing light physical or mental labour (adjusted ORs = 1.61 and 1.52, respectively; P < 0.001), having an elevated fasting glucose (DM: adjusted OR = 1.45; P < 0.05), bigger body size (overweight: adjusted OR = 1.98, obese: adjusted OR = 2.95; P < 0.001), or abdominal obesity (large waist: adjusted OR = 1.45, hypso-WHR: adjusted OR = 1.21; P < 0.05) had an increased risk for low HDL-C; however, having an increased age (adjusted OR = 0.80; P < 0.05), female sex (adjusted OR = 0.18; P < 0.001), higher monthly family income (4000–6000 yuan: adjusted OR = 0.67; P < 0.001), drinking status (adjusted OR = 0.79; P < 0.05), or increased alcohol consumption (50 ~ g/d and 75 ~ g/d: adjusted ORs = 0.36 and 0.58, respectively; P < 0.05) had the reverse tendency.
Table 6

Multivariate stepwise logistic regression analysis of factors associated with dyslipidemia

Variable

Characteristics

High TC (≥5.2 mmol/L)

High LDL-C(≥3.4 mmol/L)

Low HDL-C(<1.0 mmol/L)

High TG(≥1.7 mmol/L)

Adjusted OR

P

Adjusted OR

P

Adjusted OR

P

Adjusted OR

P

(95% CI)

(95% CI)

(95% CI)

(95% CI)

Age (years)

<40

1

 

1

 

1

 

1

 

≥40

1.10(0.94, 1.29)

0.225

1.11(0.94, 1.31)

0.224

0.80(0.69, 0.93)

0.005

0.97(0.84, 1.12)

0.66

Gender

Male

1

 

1

 

1

 

1

 

Female

1.22(0.97, 1.53)

0.084

0.81(0.63, 1.03)

0.08

0.18(0.14, 0.25)

<0.001

0.41(0.32, 0.52)

<0.001

Marital status

Single

      

1

 

Married

      

1.43(1.06, 1.93)

0.019

Monthly income

≤4000

1

   

1

   

(RMB, Yuan)

 

4000–6000

1.03(0.87, 1.22)

0.755

  

0.67(0.56, 0.81)

<0.001

  

>6000

0.76(0.64, 0.91)

0.003

  

1.07(0.88, 1.30)

0.487

  

Working type

Intense physical workers

  

1

 

1

 

1

 

Light physical workers

  

1.19(0.99, 1.45)

0.071

1.61(1.33, 1.93)

<0.001

1.51(1.28, 1.78)

<0.001

Mental workers

  

1.35(1.05, 1.74)

0.02

1.52(1.22, 1.90)

<0.001

1.58(1.30, 1.93)

<0.001

Workplace

Underground front-line

  

1

     

Underground auxiliary

  

0.96(0.78, 1.19)

0.737

    

Ground

  

1.22(0.96, 1.54)

0.101

    

Office

  

1.16(0.86, 1.56)

0.326

    

Length of service

≤3 years

1

 

1

     

4–10 years

1.23(0.79, 1.93)

0.36

1.38(0.86, 2.19)

0.181

    

>10 years

1.70(1.12, 2.58)

0.013

1.77(1.14, 2.74)

0.011

    

Smoking status

No

1

       

Yes

1.25 (1.06, 1.46)

0.007

      

Smoking index

0 ~ 

  

1

     

(roots*years)

150 ~

  

1.39(1.13, 1.71)

0.002

    

300 ~

  

1.28(1.00, 1.62)

0.048

    

450 ~

  

1.42(1.16, 1.75)

<0.001

    

Drinking Status

No

    

1

 

1

 

Yes

    

0.79(0.67, 0.95)

0.01

1.24(1.05, 1.46)

0.011

Daily drinking(g)

0 ~

1

   

1

 

1

 

25 ~

1.53(1.16, 2.00)

0.002

  

0.80(0.57, 1.11)

0.185

1.01(0.75, 1.35)

0.954

50 ~

1.81(1.30, 2.53)

<0.001

  

0.36(0.22, 0.59)

<0.001

0.73(0.51, 1.04)

0.083

75 ~

1.73(1.30, 2.32)

<0.001

  

0.58(0.40, 0.84)

0.004

1.37(1.01, 1.87)

0.044

FBG

NFG(<5.6 mmol/L)

1

 

1

 

1

 

1

 

IFG(5.6 mmol/L ≤ FBG < 7.0 mmol/L)

1.41(1.14, 1.75)

0.002

1.20(0.96, 1.50)

0.103

0.89(0.70, 1.13)

0.322

1.46(1.18, 1.81)

<0.001

DM(≥7.0 mmol/L)

1.99(1.43, 2.78)

<0.001

1.61(1.16, 2.24)

0.005

1.45(1.03, 2.06)

0.036

2.32(1.61, 3.32)

<0.001

DBP

<90 mmHg

1

 

1

   

1

 

≥90 mmHg

1.23(1.05, 1.46)

0.013

1.30(1.10, 1.53)

0.002

  

1.58(1.34, 1.86)

<0.001

BMI

normal weight, 18.5–23.9 kg/m2

1

 

1

 

1

 

1

 

underweight, <18.5 kg/m2

0.99(0.65, 1.52)

0.962

0.68(0.42, 1.12)

0.129

0.58(0.31, 1.08)

0.088

1.13(0.73, 1.74)

0.594

overweight, 24.0–27.9 kg/m2

1.43(1.22, 1.67)

<0.001

1.77(1.51, 2.08)

<0.001

1.98(1.65, 2.36)

<0.001

2.61(2.23, 3.06)

<0.001

obesity, ≥28.0 kg/m2

1.66(1.37, 2.02)

<0.001

2.35(1.93, 2.86)

<0.001

2.95(2.33, 3.72)

<0.001

3.55(2.85, 4.41)

<0.001

WC

<102 cm (male)/88 cm (female)

    

1

 

1

 
 

≥102 cm (male)/88 cm (female)

    

1.45(1.14, 1.85)

0.003

1.41(1.12, 1.78)

0.004

WHR

≤0.9(male)/0.8 (female)

    

1

 

1

 

>0.9(male)/0.8 (female)

    

1.21(1.02, 1.42)

0.026

1.25(1.08, 1.45)

0.003

TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, FBG fasting blood glucose

NFG normal fasting glucose, IFG impaired fasting glucose, DM diabetes mellitus, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, WC waist circumference, WHR waist/hip ratio

Discussion

In accordance with a World Health Organization report, of the 56 million deaths worldwide in 2012, 38 million deaths (about 68%) were caused by non-infectious diseases, which have become a severe worldwide public health burden [25, 26]. Generally, CVD is the most outstanding condition globally, and dyslipidaemia is an important public health problem, with an increasing prevalence worldwide. As dyslipidaemia is one of the most crucial independent reversible risk factors for CVDs, preventive measures targeting the popular with dyslipidaemia can reduce the morbidity and mortality of CVDs [27]. To effectively prevent CVDs, lifestyle modifications, policy changes, and pharmacotherapy are required. The current study is one of the largest scale occupational, population-based studies on dyslipidaemia that comprehensively assessed the prevalence of dyslipidaemia and the associated risk factors of dyslipidaemia in coal miners in China.

The average serum TC, LDL-C, and TG levels have increased quickly in China [2830]. Findings from the 2002 Chinese National Nutrition and Health Survey (CNHS) [28, 31] demonstrated that the respective mean levels of TC, LDL-C, and TG were 3.81 mmol/L, 2.21 mmol/L, and 1.10 mmol/L. The China National Diabetes and Metabolic Disorders Study demonstrated that the respective mean levels of TC, LDL-C, and TG were 4.72 mmol/L, 2.68 mmol/L and 1.57 mmol/L [32]; the corresponding average levels observed in the current study were higher: 5.01 mmol/L, 3.15 mmol/L, and 1.90 mmol/L, respectively. Furthermore, in our study, the average level of serum HDL-C was somewhat lower (1.21 mmol/L) than that (1.30 mmol/L) reported in the two aforementioned studies [28, 31, 32].

Our current study’s findings indicated that 68.28% of Chinese coal miners (men, 71.36%; women, 51.68%) had at least one type of dyslipidaemia. This value is higher than that reported by the 2002 CNHS (18.6%) [28] and by recent studies on Chinese adults [27, 33, 34]. Our findings showed that the prevalence of dyslipidaemia is high in coal miners. In line with the results of previous studies [27, 33, 34], which found that the main types of dyslipidaemia in China are high TG levels, our study showed that the major contributor of dyslipidaemia was high TG levels (40.46%). In the past 20 years, the most prominent change in the concentrations of serum lipids in the people of Beijing and Guangzhou in China was an increase in the TG levels, possibly as a result of the increase in carbohydrates and fats in their diet [3537], whereas the most common lipid disorder in Western countries was high TC levels [38]. Furthermore, China has a low mortality due to coronary heart disease, and the relationship between a low serum TC level and low fat and cholesterol dietary intake was identified as the main cause of this finding [39]. However, with economic growth and westernized lifestyle, especially dietary patterns, the prevalence of high TC levels increased in China [27, 34], and the prevalence of a high TC level (38.08%) found in this study was significantly higher than the average Chinese national level [33]. Projected trends in the increased TC level would lead to an increase of approximately 9.2 million cardiovascular events from 2010 to 2030 [40]. The association between regional disparities in the type of dyslipidaemia and lifestyle, diet, and other factors requires further investigation. Our findings of the high prevalence of dyslipidaemia in coal miners highlight crucial public health implications what could explain why this population is susceptible to CVDs [15].

In addition to the prevalence of dyslipidaemia, our study identified the potential risk factors for each type of dyslipidaemia: type of work, hypertension, BMI, WC, etc. Previous studies have reported an association between age and dyslipidaemia [27, 29, 38, 41]. The mechanisms underlying the role of age on serum lipid panel results may be hereditary characteristics, degenerative processes, weight gain, and gradual development of insulin resistance [38]. In the current study, univariate logistic regression analysis demonstrated that the prevalence of high TC levels, LDL-C levels, and TG levels significantly increased with advanced age (≥40 years); however, the prevalence of low HDL-C levels decreased, which was in accordance with the results of another previous study [42]. However, multivariate analysis only confirmed the relationship of age and low HDL-C levels. Socio-demographic factors, in line with previous studies, were consistently associated with the prevalence of dyslipidaemia [27, 29, 33]. Multivariate analysis in this study also showed that a married status was an independent risk factor for a high TG level; however, female sex was inversely related with the prevalence of the low HDL-C and high TG levels, and a high monthly income was inversely associated with the prevalence of a high TC and low HDL-C level.

Regarding working conditions, we found that underground front-line workers had the lowest prevalence of each kind of dyslipidaemia, and workers who did intense physical work had the lowest prevalence of dyslipidaemia, because the former undertake work of a higher labour intensity. Results of multivariate logistic regression analysis showed that those who did light physical and mental work were inclined to suffer high LDL-C and TG levels and a low HDL-C level than those who did intense physical work. Furthermore, in univariate logistic regression analysis, compared to underground front-line workers, ground workers or office workers and underground auxiliary workers, who frequently but not continuously work under the coal mine, had higher ORs for the prevalence of all dyslipidaemia components; however, multivariate analysis did not confirm these relationships. Results of multivariable logistic regression analysis in this study showed that the extended length of service was an independent risk factor for high TC and high LDL-C levels. Contrary to the expected results, participants working inside the coal mine did not show a high prevalence of dyslipidaemia, possibly because of the healthy worker effect and the underground front-line workers may be younger, stronger, and in good health.

With regard to health behaviours, smoking is a main health issue in China; the prevalence of smoking was 57.69% in our study. Results of multivariate logistic regression analysis also demonstrated that smoking status was associated with high TC levels. With regard to the smoking index, a positive association was shown between a smoking index and high LDL-C levels. Drinking is also a main health issue in China; the prevalence of drinking was 41.49% in our study. There was an inverse relationship between drinking status and low HDL-C levels in our study, which was in line with the findings of previous research studies [42, 43], and the trend was the opposite for a high TG level. Regarding alcohol consumption per day, an inverse relationship found for low HDL-C levels, although a positive relationship was noted for the prevalence of high TC and high TG levels.

Regarding the health condition, metabolic disturbances, including pathoglycaemia, hypertension, overweight/obesity, abdominal obesity, and dyslipidaemia, occur almost simultaneous with each other and are intensively related to subsequent CVD; the most common underlying mechanism is insulin resistance [44]. Hypertension and diabetes have been reported as risk factors for dyslipidaemia [38, 4547]. In our study, the prevalence rate of hypertension was as high as 31.38%, and that of IFG/ DM was 14.0%. The increase of dyslipidaemia could have contributed to the high prevalence of hypertension and diabetes among our subjects. Results of multivariate logistic regression analysis showed that participants with elevated fasting glucose levels (IFG/DM) were positively related with all types of dyslipidaemia components; furthermore, a high DBP was a risk factor for high TC levels, high LDL-C levels, and high TG levels. These results proposed that the factors causing dyslipidaemia and the outcomes of dyslipidaemia are similar among people of different ethnicities. Thus, the rising prevalence of dyslipidaemia in China could cause analogous cardio-cerebral-vascular outcomes as it did in Western countries [29].

The findings of this study are in line with several previous studies [38, 45, 46, 4850] that demonstrated that the prevalence of dyslipidaemia rises with an increase in the BMI; additionally, we found that all types of dyslipidaemia were associated with the accumulation of adipose tissue. The abnormal blood lipid panel in overweight and obese people is probably caused by insulin resistance [44]. In China, 3.8% of men and 5.0% of women were obese in 2013 [51], but this proportion was almost 20% in some cities [52]. The respective prevalence rates of overweight and obesity were 39.00 and 17.55% among coal miners in our study; these values are higher than the Chinese national average values. On the basis of our study’s data, we interpreted that obesity is at a high prevalence among coal miners, and it will undoubtedly affect the prevalence of dyslipidaemia. Therefore, obesity in this professional group needs to be noticed. In our research, we found that the prevalence of abdominal obesity among coal miners in China was 13.50%. Other researchers have observed associations between dyslipidaemia and abdominal obesity [43, 53], and our study found that a large WC and hypso-WHR were risk factors for low HDL-C levels and high TG levels. In summary, dyslipidaemia, particularly high TG is a very common and important health problem among Chinese coal miners. Demographic characteristics (advanced age, male sex, marital status, and monthly family income); working characteristics (working type and length of service); lifestyles (smoking, smoking index, drinking status, and alcohol consumption per day); and health conditions (elevated fasting glucose, hypertension, obesity, and abdominal obesity) were closely related to dyslipidaemia. Effective occupational health education must be provided and urgent occupational protective measures must be taken to control the epidemic of dyslipidaemia among coal mine occupational groups.

Several limitations may exist in our study. First, as this was a cross-sectional study, the results are prone to be affected by the recall bias and unmeasured confounding factors. Second, other risk factors (e.g., environmental air pollutants, dietary intake, and other health conditions) were not considered. Finally, this was a cross-sectional study, so no causal relationships could be precisely delineated.

Conclusions

Our current study provides dependable and present epidemic characteristics on dyslipidaemia among Chinese coal miners. Dyslipidaemia, especially high TG levels, is a very prevalent and major health issue among Chinese coal miners.

Abbreviations

BMI: 

Body mass index

CNHS: 

Chinese National Nutrition and Health Survey

CVD: 

Cardiovascular disease

DBP: 

Diastolic blood pressure

DM: 

Diabetes mellitus

FBG: 

Fasting blood glucose

HDL-C: 

High-density lipoprotein cholesterol

IFG: 

Impaired fasting glucose

LDL-C: 

Low-density lipoprotein cholesterol

NFG: 

Normal fasting glucose

OR: 

Odds ratio

SBP: 

Systolic blood pressure

TC: 

Total cholesterol

TG: 

Triglyceride

WC: 

Waist circumference

WHR: 

Waist-hip ratio

Declarations

Acknowledgments

Thanks for the support of Graduate Student Innovation Center in Shanxi Province of China and the assistance of all interviewers and subjects who participated in our study.

Funding

The study was supported by grants from the National Natural Science Foundation of China (81473073). The funding source had no role in the study design, data collection, data analysis, data interpretation, or writing of the article.

Availability of data and materials

The datasets used and analysed during the current study available from the corresponding author on reasonable request.

Authors’ contributions

JH, CS, NQ and TW made substantial contributions to conception and design, and acquisition of data. RT, HW, HZ and YS analyzed the data. YF was a major contributor in writing the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate

This study was approved by the ethics committee of Shanxi Medical University (ethical application reference: HX201201). Written consent was obtained from all participants.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Environmental Health, School of Public Health, Shanxi Medical University
(2)
Department of Surgery, General Hospital of Datong Coal Mining Group
(3)
Department of Health Statistics, School of Public Health, Shanxi Medical University
(4)
Institute for Bacteria disease prevention and control & disinfection, Hebei province center for disease control and prevention

References

  1. Laslett LJ, Alagona P Jr, Clark BA 3rd, Drozda JP Jr, Saldivar F, Wilson SR, Poe C, Hart M. The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology. J Am Coll Cardiol. 2012;60:S1–49.View ArticlePubMedGoogle Scholar
  2. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–47.View ArticlePubMedGoogle Scholar
  3. Janus ED, Tideman PA, Dunbar JA, Kilkkinen A, Bunker SJ, Philpot B, Tirimacco R, Mc Namara K, Heistaro S, Laatikainen T. Dyslipidaemia in rural Australia: prevalence, awareness, and adherence to treatment guidelines in the greater green triangle risk factor study. Med J Aust. 2010;192:127–32.PubMedGoogle Scholar
  4. Goff DC Jr, Bertoni AG, Kramer H, Bonds D, Blumenthal RS, Tsai MY, Psaty BM. Dyslipidemia prevalence, treatment, and control in the multi-ethnic study of atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation. 2006;113:647–56.View ArticlePubMedGoogle Scholar
  5. Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ. Coordinating Committee of the National Cholesterol Education P. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. J Am Coll Cardiol. 2004;44:720–32.View ArticlePubMedGoogle Scholar
  6. Enterline PE. A review of mortality data for American coal miners. Ann N Y Acad Sci. 1972;200:260–72.View ArticlePubMedGoogle Scholar
  7. Liu L, Wen F, Xu X, Wang L. Effective resources for improving mental health among Chinese underground coal miners: perceived organizational support and psychological capital. J Occup Health. 2015;57:58–68.View ArticlePubMedGoogle Scholar
  8. Davies HW, Teschke K, Kennedy SM, Hodgson MR, Hertzman C, Demers PA. Occupational exposure to noise and mortality from acute myocardial infarction. Epidemiology. 2005;16:25–32.View ArticlePubMedGoogle Scholar
  9. Bjor B, Burstrom L, Eriksson K, Jonsson H, Nathanaelsson L, Nilsson T. Mortality from myocardial infarction in relation to exposure to vibration and dust among a cohort of iron-ore miners in Sweden. Occup Environ Med. 2010;67:154–8.View ArticlePubMedGoogle Scholar
  10. Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA. 2006;295:1127–34.View ArticlePubMedPubMed CentralGoogle Scholar
  11. Rodriguez-Fernandez R, Rahajeng E, Viliani F, Kushadiwijaya H, Amiya RM, Bangs MJ. Non-communicable disease risk factor patterns among mining industry workers in Papua, Indonesia: longitudinal findings from the cardiovascular outcomes in a Papuan population and estimation of risk (COPPER) study. Occup Environ Med. 2015;72:728–35.View ArticlePubMedPubMed CentralGoogle Scholar
  12. Oliveira A, Cacodcar J, Motghare DD. Morbidity among iron ore mine workers in Goa. Indian J Public Health. 2014;58:57–60.View ArticlePubMedGoogle Scholar
  13. Conklin DJ, Barski OA, Lesgards JF, Juvan P, Rezen T, Rozman D, Prough RA, Vladykovskaya E, Liu S, Srivastava S, Bhatnagar A. Acrolein consumption induces systemic dyslipidemia and lipoprotein modification. Toxicol Appl Pharmacol. 2010;243:1–12.View ArticlePubMedGoogle Scholar
  14. Fomenko DV, Gorokhova LG, Panev NI, Kazitskaia AS, Bondarev OI. Clinical and experimental studies of metabolic response to chronic exposure to coal dust. Med Tr Prom Ekol. 2011;(2):15–21.Google Scholar
  15. Landen DD, Wassell JT, McWilliams L, Patel A. Coal dust exposure and mortality from ischemic heart disease among a cohort of U.S. coal miners. Am J Ind Med. 2011;54:727–33.View ArticlePubMedGoogle Scholar
  16. Mincheva L, Khadzhiolova I. An occupational physiology study at the Asarel mining and milling works--screening for risk factors of the cardiovascular system in workers in an open-pit mine. Probl Khig. 1995;20:47–59.PubMedGoogle Scholar
  17. Haskell WL. Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy. J Cardiovasc Nurs. 2003;18:245–55.View ArticlePubMedGoogle Scholar
  18. Costello J, Ortmeyer CE, Morgan WK. Mortality from heart disease in coal miners. Chest. 1975;67:417–21.View ArticlePubMedGoogle Scholar
  19. Vankhanen VV. Characteristics of lipid metabolism in deep mine workers and the ways of its alimentary correction. Vopr Pitan. 1992;(1):26–31.Google Scholar
  20. Zhonghua Xin Xue Guan Bing Za Zhi. Joint committee issued Chinese guideline for the management of dyslipidemia in a. [2016 Chinese guideline for the management of dyslipidemia in adults]. 2016;44:833–53.Google Scholar
  21. Chen C, Lu FC. Department of Disease Control Ministry of health PRC. The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci. 2004;17(Suppl):1–36.PubMedGoogle Scholar
  22. World Health Organization. Waist Circumference and Waist–Hip Ratio: Report of a WHO Expert Consultation. 2008. http://apps.who.int/iris/bitstream/10665/44583/1/9789241501491_eng.pdf. Accessed 8–11 December 2008.
  23. American DA. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31(Suppl 1):S55–60.View ArticleGoogle Scholar
  24. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint National Committee (JNC 8). JAMA. 2014;311:507–20.View ArticlePubMedGoogle Scholar
  25. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren WM, Albus C, Benlian P, Boysen G, Cifkova R, et al. European guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). G Ital Cardiol (Rome). 2013;14:328–92.Google Scholar
  26. Mortality GBD. Causes of death C. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015;385:117–71.View ArticleGoogle Scholar
  27. Ni WQ, Liu XL, Zhuo ZP, Yuan XL, Song JP, Chi HS, Xu J. Serum lipids and associated factors of dyslipidemia in the adult population in Shenzhen. Lipids Health Dis. 2015;14:71.View ArticlePubMedPubMed CentralGoogle Scholar
  28. Zhao WH, Zhang J, Zhai Y, You Y, Man QQ, Wang CR, Li H, Li Y, Yang XG. Blood lipid profile and prevalence of dyslipidemia in Chinese adults. Biomed Environ Sci. 2007;20:329–35.PubMedGoogle Scholar
  29. Wang S, Xu L, Jonas JB, You QS, Wang YX, Yang H. Prevalence and associated factors of dyslipidemia in the adult Chinese population. PLoS One. 2011;6:e17326.View ArticlePubMedPubMed CentralGoogle Scholar
  30. Ruixing Y, Qiming F, Dezhai Y, Shuquan L, Weixiong L, Shangling P, Hai W, Yongzhong Y, Feng H, Shuming Q. Comparison of demography, diet, lifestyle, and serum lipid levels between the Guangxi Bai Ku Yao and Han populations. J Lipid Res. 2007;48:2673–81.View ArticlePubMedGoogle Scholar
  31. Zhonghua Xin Xue Guan Bing Za Zhi. Joint Committee for Developing Chinese guidelines on P, Treatment of Dyslipidemia in A. [Chinese guidelines on prevention and treatment of dyslipidemia in adults]. 2007;35:390–419.Google Scholar
  32. Yang W, Xiao J, Yang Z, Ji L, Jia W, Weng J, Lu J, Shan Z, Liu J, Tian H, et al. Serum lipids and lipoproteins in Chinese men and women. Circulation. 2012;125:2212–21.View ArticlePubMedGoogle Scholar
  33. Huang Y, Gao L, Xie X, Tan SC. Epidemiology of dyslipidemia in Chinese adults: meta-analysis of prevalence, awareness, treatment, and control. Popul Health Metr. 2014;12:28.View ArticlePubMedPubMed CentralGoogle Scholar
  34. Zhang FL, Xing YQ, Wu YH, Liu HY, Luo Y, Sun MS, Guo ZN, Yang Y. The prevalence, awareness, treatment, and control of dyslipidemia in northeast China: a population-based cross-sectional survey. Lipids Health Dis. 2017;16:61.View ArticlePubMedPubMed CentralGoogle Scholar
  35. Li LM, Rao KQ, Kong LZ, Yao CH, Xiang HD, Zhai FY, Ma GS, Yang XG, Technical working Group of China National N, health S. [a description on the Chinese national nutrition and health survey in 2002]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26:478-84.Google Scholar
  36. Li Z, Yang R, Xu G, Xia T. Serum lipid concentrations and prevalence of dyslipidemia in a large professional population in Beijing. Clin Chem. 2005;51:144–50.View ArticlePubMedGoogle Scholar
  37. Zhou B, Rao X, Dennis BH, Li Y, Zhuo Q, Folsom AR, Yang J, Li Y, Stamler J, Cao T, et al. The relationship between dietary factors and serum lipids in Chinese urban and rural populations of Beijing and Guangzhou. PRC-USA cardiovascular and cardiopulmonary research group. Int J Epidemiol. 1995;24:528–34.View ArticlePubMedGoogle Scholar
  38. Bayram F, Kocer D, Gundogan K, Kaya A, Demir O, Coskun R, Sabuncu T, Karaman A, Cesur M, Rizzo M, et al. Prevalence of dyslipidemia and associated risk factors in Turkish adults. J Clin Lipidol. 2014;8:206–16.View ArticlePubMedGoogle Scholar
  39. Johnson CL, Rifkind BM, Sempos CT, Carroll MD, Bachorik PS, Briefel RR, Gordon DJ, Burt VL, Brown CD, Lippel K, et al. Declining serum total cholesterol levels among US adults. The National Health and nutrition examination surveys. JAMA. 1993;269:3002–8.View ArticlePubMedGoogle Scholar
  40. Moran A, Gu D, Zhao D, Coxson P, Wang YC, Chen CS, Liu J, Cheng J, Bibbins-Domingo K, Shen YM, et al. Future cardiovascular disease in china: markov model and risk factor scenario projections from the coronary heart disease policy model-china. Circ Cardiovasc Qual Outcomes. 2010;3:243–52.View ArticlePubMedPubMed CentralGoogle Scholar
  41. Wu JY, Duan XY, Li L, Dai F, Li YY, Li XJ, Fan JG. Dyslipidemia in Shanghai. China Prev Med. 2010;51:412–5.View ArticlePubMedGoogle Scholar
  42. Sun GZ, Li Z, Guo L, Zhou Y, Yang HM, Sun YX. High prevalence of dyslipidemia and associated risk factors among rural Chinese adults. Lipids Health Dis. 2014;13:189.View ArticlePubMedPubMed CentralGoogle Scholar
  43. Erem C, Hacihasanoglu A, Deger O, Kocak M, Topbas M. Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study. Endocrine. 2008;34:36–51.View ArticlePubMedGoogle Scholar
  44. Houston MC, Basile J, Bestermann WH, Egan B, Lackland D, Hawkins RG, Moore MA, Reed J, Rogers P, Wise D, Ferrario CM. Addressing the global cardiovascular risk of hypertension, dyslipidemia, and insulin resistance in the southeastern United States. Am J Med Sci. 2005;329:276–91.View ArticlePubMedGoogle Scholar
  45. Sharma U, Kishore J, Garg A, Anand T, Chakraborty M, Lali P. Dyslipidemia and associated risk factors in a resettlement colony of Delhi. J Clin Lipidol. 2013;7:653–60.View ArticlePubMedGoogle Scholar
  46. Mirrakhimov EM, Kerimkulova AS, Lunegova OS, Mirrakhimov AE, Nabiev MP, Neronova KV, Bayramukova AA, Alibaeva NT, Satarov N. The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (central Asian nation) population. BMC Res Notes. 2014;7:411.View ArticlePubMedPubMed CentralGoogle Scholar
  47. Haffner SM. Management of dyslipidemia in adults with diabetes. Diabetes Care. 1998;21:160–78.View ArticlePubMedGoogle Scholar
  48. Shen Z, Munker S, Wang C, Xu L, Ye H, Chen H, Xu G, Zhang H, Chen L, Yu C, Li Y. Association between alcohol intake, overweight, and serum lipid levels and the risk analysis associated with the development of dyslipidemia. J Clin Lipidol. 2014;8:273–8.View ArticlePubMedGoogle Scholar
  49. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341:1097–105.View ArticlePubMedGoogle Scholar
  50. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study. Circulation. 1983;67:968–77.View ArticlePubMedGoogle Scholar
  51. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2014;384:766–81.View ArticlePubMedPubMed CentralGoogle Scholar
  52. World Health Organization. Obesity and overweight. 2003. http://www.who.int/dietphysicalactivity/media/en/gsfs_obesity.pdf. Accessed 2003.
  53. Villegas R, Kearney PM, Perry IJ. The cumulative effect of core lifestyle behaviours on the prevalence of hypertension and dyslipidemia. BMC Public Health. 2008;8:210.View ArticlePubMedPubMed CentralGoogle Scholar

Copyright

© The Author(s). 2017

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